Characterization of subcolumnar reserve cells and other epithelia of human uterine cervix

1987 ◽  
Vol 54 (1) ◽  
pp. 98-110 ◽  
Author(s):  
W. Weikel ◽  
R. Wagner ◽  
R. Moll
Keyword(s):  
2000 ◽  
Vol 4 (4) ◽  
pp. 204-207
Author(s):  
Carlos Roberto de Resende Miranda ◽  
Liane Deligdisch ◽  
Joan Gil ◽  
Peter Dottino

Oncology ◽  
2001 ◽  
Vol 60 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Yasushi Saga ◽  
Mitsuaki Suzuki ◽  
Natsuko Tamura ◽  
Michitaka Ohwada ◽  
Ikuo Sato

2006 ◽  
Vol 119 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Angel Chao ◽  
Tzu-Hao Wang ◽  
Yun-Shien Lee ◽  
Swei Hsueh ◽  
An-Shine Chao ◽  
...  

Author(s):  
Verónica Medina Bañuelos ◽  
Mónica Orozco-Flores ◽  
Jorge Perez-Gonzalez ◽  
Fabián Torres-Robles ◽  
Lisbeth Camargo-Marín ◽  
...  

2002 ◽  
Vol 12 (1) ◽  
pp. 92-98 ◽  
Author(s):  
A Cabanillas-Saez ◽  
J. A Schalper ◽  
S. M Nicovani ◽  
M. I Rudolph

Abstract.Cabanillas-Saez A, Schalper JA, Nicovani SM, Rudolph MI. Characterization of mast cells according to their content of tryptase and chymase in normal and neoplastic human uterine cervix.Mast cells (MC) have been associated with diverse human cancers. The primary function of these cells is to store and release a number of biologically active mediators, including the serine proteases tryptase and chymase. These proteases have been closely related with angiogenesis and tumor invasion, two critical steps during tumor progression. In the present work we analyzed the presence of MC in human uterine cervix from both normal and neoplastic tissues by using metachromatic, immunohistochemical, and enzymohistochemical staining. Tryptase-positive (MCT)– and tryptase/chymase-positive (MCTC)–mast cells were found in both normal and neoplastic tissues. The phenotype predominantly expressed in normal tissues as well as in benign and malignant lesions of the uterine cervix was the MCT. The total number of MC remained constant through the different stages of malignant transformation (cervical intraepithelial neoplasia grade 1–3) but a significant increase in the invasive carcinoma (IC) group was observed, this increase being mainly due to the MCT phenotype. Furthermore, we detected abundant MCT but not MCTC infiltrating tumors in sections of IC. Regarding the potent angiogenic properties described for tryptase, these findings suggest that in advanced stages of malignancy the significant number of MCT distributed within the cervical tissues could provide an effective mechanism to create the abundantly vascularized microenvironment required for tumor cells to proliferate and disseminate.


2001 ◽  
Vol 65 (2) ◽  
pp. 375-383 ◽  
Author(s):  
Jorgelina Varayoud ◽  
Jorge G. Ramos ◽  
Paulo P. Joazeiro ◽  
Gregorio S. Montes ◽  
Mónica M. Muñoz de Toro ◽  
...  

1995 ◽  
Vol 34 (4) ◽  
pp. 241-247 ◽  
Author(s):  
PEGGY A. CROWLEY-NOWICK ◽  
MARIA BELL ◽  
ROBERT P. EDWARDS ◽  
DANIEL MCCALLISTER ◽  
HAZEL GORE ◽  
...  

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 286-292 ◽  
Author(s):  
S. Nofech-Mozes ◽  
G. Rasty ◽  
N. Ismiil ◽  
A. Covens ◽  
M. A. Khalifa

Endocervical adenocarcinomas are rare and aggressive neoplasms. Papillary serous endocervical adenocarcinomas are the rarest form of endocervical adenocarcinomas. This tumor exhibits morphologic similarities to its counterparts commonly seen in the endometrium, fallopian tubes, ovaries, and peritoneum, which are known to have an aggressive behavior. Because of the rarity of this tumor, little is known about its immunophenotyping. In this study, we included ten cases of papillary serous carcinomas arising from the uterine cervix (PSCC) diagnosed in the absence of a primary endometrial malignancy. We studied their immunohistochemical profile, using a panel of antibodies against Ki67, bcl-2, p53, carcinoembryonic antigen (CEA), and CD10, and compared them to 20 consecutive cases of cervical adenocarcinoma of conventional cell subtypes (CAC) (15 mucinous, 3 adenosquamous, and 2 endometrioid). Immunostaining was recorded semiquantitatively. Patients with PSCC ranged in age from 27 to 79 years (mean = 51.6 ± 19.1), while the conventional cell subtypes control group were 28–90 years old (mean = 47.5 ± 16.9). Only p53 and CEA immunostaining significantly correlated with the PSCC morphology (P= 0.001 and P= 0.016, respectively) as shown by Cochran–Mantel–Haenszel Statistics (Modified Ridit Scores). PSCC is a distinctive immunophenotypic subtype of endocervical adenocarcinoma with significantly higher p53 and lower CEA reactivity than other more common histologic subtypes.


2010 ◽  
Vol 283 (4) ◽  
pp. 861-869
Author(s):  
Ling-Min Liao ◽  
Min Zheng ◽  
Long Huang ◽  
Hui Ding ◽  
Li He ◽  
...  

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