Modulating influence of dehydroepiandrosterone administration on the morphology and enzyme phenotype of dimethylaminoazobenzene-induced hepatocellular foci and nodules

1988 ◽  
Vol 55 (1) ◽  
Author(s):  
Malcolm A. Moore ◽  
Edgar Weber ◽  
Peter Bannasch
Keyword(s):  
Enzyme Phenotype

scholarly journals Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene.

1979 ◽  
Vol 150 (4) ◽  
pp. 878-887 ◽  
Author(s):  
A L Reddy ◽  
P J Fialkow
Keyword(s):  
Phosphoglycerate Kinase ◽  
The Other ◽  
Chemical Carcinogen ◽  
Malignant Cells ◽  
X Chromosomes ◽  
Cellular Origin ◽  
Normal Tissues ◽  
Two Populations ◽  
Single Enzyme ◽  
Enzyme Phenotype

The cellular origin of tumors induced by the chemical carcinogen 3-methylcholanthrene (MCA) was studied in mice with X-chromosome inactivation mosaicism. Because only one of the two X-chromosomes is active in XX somatic cells, a female heterozygous at the X-linked phosphoglycerate kinase (PGK-1) locus for the usual Pgk-1b gene and the variant Pgk-1a has two populations of cells, in the cells of one population, Pgk-1b is active and B-type enzyme is synthesized, whereas in cells of the other population, A-type enzyme is produced. Both enzyme types are found in normal tissues from these mosaic mice. A tumor developing from a single cell exhibits only one of the two PGK enzyme types, whereas a tumor with a multicellular origin expresses both enzymes (i.e., it has a double-enzyme phenotype). Five fibrosarcomas developing at the site of injection of 0.2 or 2.0 mg of MCA were analyzed. 36 of 38 fragments from the five tumors had double-enzyme PGK phenotypes. One piece from each of two tumors showed a single-enzyme phenotype. Histological, cell culture, and cloning studies indicate that the double-enzyme phenotypes reflect the presence of both types of malignant cells and not admixture of normal with neoplastic elements in the specimens tested for PGK. The results suggest strongly that these fibrosarcomas have a multicellular origin.

scholarly journals Effects of Modifying Agents on Conformity of Enzyme Phenotype and Proliferative Potential in Focal Preneoplastic and Neoplastic Liver Cell Lesions in Rats

1992 ◽  
Vol 83 (11) ◽  
pp. 1154-1165 ◽  
Author(s):  
Hiroyuki Tsuda ◽  
Keisuke Ozaki ◽  
Satoshi Uwagawa ◽  
Shuji Yamaguchi ◽  
Kazuo Hakoi ◽  
...  
Keyword(s):  
Liver Cell ◽  
Proliferative Potential ◽  
Enzyme Phenotype

scholarly journals Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver

1996 ◽  
Vol 17 (11) ◽  
pp. 2441-2448 ◽  
Author(s):  
Hiroyuki Tsuda ◽  
Makoto Asamoto ◽  
Yoshio Iwahori ◽  
Takaaki Hori ◽  
Tomonori Ota ◽  
...  
Keyword(s):  
Rat Liver ◽  
Preneoplastic Lesions ◽  
Enzyme Phenotype

scholarly journals Abnormal enzyme phenotype (e1 a e1 f): Normal response to succinylcholine

1979 ◽  
Vol 26 (2) ◽  
pp. 99-103 ◽  
Author(s):  
M. J. McQueen ◽  
F. Lepinskie ◽  
R. D. Strickland ◽  
A. Trimble
Keyword(s):  
Normal Response ◽  
Enzyme Phenotype

Cruciferous vegetables and drug-metabolising enzyme phenotype

Toxicology ◽  
2000 ◽  
Vol 148 (1) ◽  
pp. 66
Author(s):  
Carol A. Murray ◽  
Barbara Elcombe ◽  
Matthew Harrison ◽  
Alun Barton ◽  
Angus Reid ◽  
...  
Keyword(s):  
Cruciferous Vegetables ◽  
Enzyme Phenotype

123. Reversal of enzyme phenotype of thymidine metabolism in induced differentiation of leukemia cells

1992 ◽  
Vol 46 (5-7) ◽  
pp. 299
Author(s):  
Y Yamaji ◽  
T Shiotani ◽  
Y Hashimoto ◽  
J Fujita ◽  
K Ikeda ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Induced Differentiation ◽  
Enzyme Phenotype

Implications of Genotype and Enzyme Phenotype in Pyridoxine Response of Patients with Type I Primary Hyperoxaluria

2005 ◽  
Vol 25 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Carla G. Monico ◽  
Julie B. Olson ◽  
Dawn S. Milliner
Keyword(s):  
Primary Hyperoxaluria ◽  
Type I ◽  
Enzyme Phenotype

scholarly journals Cambial Isoperoxidase Patterns in Castanea

1986 ◽  
Vol 4 (1) ◽  
pp. 14-16 ◽  
Author(s):  
F.S. Santamour ◽  
A.J. McArdle ◽  
R.A. Jaynes
Keyword(s):  
Genetic Basis ◽  
Banding Patterns ◽  
Chinese Chestnut ◽  
Single Tree ◽  
European Chestnut ◽  
Sexual Compatibility ◽  
Cambial Zone ◽  
Graft Compatibility ◽  
Enzyme Phenotype

Only 3 major and variable anodal isoperoxidase bands were found in the cambial zone of 10 Castanea species. Even though the numbers of plants tested in several taxa were low, it appeared that certain banding patterns could be characteristic for some species. Thus, C. dentata and other American species (C. alnifolia, C. ashei, C. ozarkensis, C. pumila) exhibited only band A. The Japanese chestnut (C. crenata) and C. seguinii had only band B. The isoenzyme phenotypes A, B, and AB were found in the European chestnut (C. sativa) while our single tree of C. henryii had both A and B bands. Chinese chestnut (C. mollissima) contained trees with 4 isoenzyme phenotypes (A, AB, B, BC). The distribution of isoperoxidase banding patterns, coupled with widespread sexual compatibility, indicated that the categorization of chestnut species into different taxonomic sections may have little importance from a genetic basis. The possible influence of enzyme phenotype on graft compatibility is discussed.

Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

2014 ◽  
Vol 118 (4) ◽  
pp. 469-474
Author(s):  
C. Kragelund ◽  
S.B. Jensen ◽  
C. Hansen Cand Scient ◽  
K. Broesen ◽  
L.A. Torpet ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Cytochrome P450 Enzyme ◽  
P450 Enzyme ◽  
Oral Lichen ◽  
Enzyme Phenotype
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