scholarly journals Abnormal enzyme phenotype (e1 a e1 f): Normal response to succinylcholine

1979 ◽  
Vol 26 (2) ◽  
pp. 99-103 ◽  
Author(s):  
M. J. McQueen ◽  
F. Lepinskie ◽  
R. D. Strickland ◽  
A. Trimble
Keyword(s):  
Normal Response ◽  
Enzyme Phenotype

OESTROGEN-PROGESTERONE RELATIONSHIPS IN THE INDUCTION OF OESTRUS IN SPAYED HEIFERS

1969 ◽  
Vol 45 (1) ◽  
pp. 99-109 ◽  
Author(s):  
M. J. CARRICK ◽  
J. N. SHELTON
Keyword(s):  
Behavioural Response ◽  
Normal Response ◽  
Oestradiol Benzoate ◽  
Small Doses ◽  
Refractory State ◽  
Increased Sensitivity ◽  
Repeated Doses ◽  
Effective Doses ◽  
Response Line ◽  
Normal Sensitivity

SUMMARY Experiments were conducted to examine the behavioural response of spayed heifers to oestrogen, and its modification by progesterone. In two groups of heifers, the median effective doses (MED) of oestradiol benzoate (ODB) were 121 and 132 μg. Repeated doses of ODB at physiological levels did not induce a state of refractoriness; in this respect the heifer is dissimilar to the ewe. However, repeated doses of 10 mg. ODB induced refractoriness to 400 μg. ODB. When such refractory heifers were treated with 10 mg. progesterone/day for 5 days, they showed a normal response to 400 μg. ODB given 3 days later. This return to normal sensitivity was not sustained, and pretreatment with progesterone was necessary for a normal response to subsequent small doses of ODB. The transient removal of the refractory state appears not to be due to a simple synergistic effect of residual progesterone, but to an effect of preconditioning a neural centre to respond to oestrogen. Increasing the duration of pretreatment with progesterone beyond 5 days did not result in a greater sensitivity to ODB. Pretreatment with progesterone in heifers not made refractory to ODB did not result in an increased sensitivity to ODB. Moreover, up to 7 days after termination of the progesterone treatment, the response to ODB was reduced and the slope of the dose-response line was less steep than when ODB was injected alone. The reduction of the response was more pronounced with 40 mg. progesterone/day than with 10 mg. The possible significance of these results in intact animals is discussed.

scholarly journals Normal Response to Fibrinolytic Challenge in COVID-19 Patients: Viscoelastic Evaluation Using Urokinase-Modified Thromboelastography

2021 ◽  
Author(s):  
Mauro Panigada ◽  
Andrea Meli ◽  
Paolo Properzi ◽  
Giacomo Grasselli ◽  
Giacomo Emilio Iapichino
Keyword(s):  
Normal Response

Role of endothelium-derived relaxing factors in the renal response to vasoactive agents in hypothyroid rats

2003 ◽  
Vol 285 (1) ◽  
pp. E182-E188 ◽  
Author(s):  
Juan Manuel Moreno ◽  
Rosemary Wangensteen ◽  
Juan Sainz ◽  
Isabel Rodríguez-Gomez ◽  
Virginia Chamorro ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Ang Ii ◽  
Vasoactive Agents ◽  
Normal Response ◽  
No Donor ◽  
Increased Sensitivity ◽  
Renal Vascular ◽  
And Control ◽  
Renal Responses

This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in the abnormal renal vascular reactivity of hypothyroid rats. Renal responses to vasoconstrictors [VC: phenylephrine (PHE) and ANG II] and vasodilators [VD: ACh, sodium nitroprusside (SNP), and papaverine (PV)] were studied in kidneys from control and hypothyroid rats under normal conditions and after NO or EDHF blockade. NO was blocked by the administration of Nω-nitro-l-arginine methyl ester (l-NAME) and EDHF by the administration of tetraethylammonium (TEA) or by an increased extracellular K+. The response to VC was also evaluated after endothelium removal. Hypothyroid kidneys showed reduced responsiveness to PHE and a normal response to ANG II. l-NAME and TEA administration produced an increased sensitivity to PHE and to ANG II in control preparations. l-NAME also increased the response to PHE in hypothyroid kidneys, but the differences between control and hypothyroid kidneys were maintained. TEA administration did not change the response to either VC in hypothyroid preparations. In endothelium-removed preparations, TEA was unable to increase pressor responsiveness to VC. Hypothyroid kidneys showed reduced responsiveness to ACh and SNP and normal response to PV. The differences between hypothyroid and control preparations in the responses to ACh and SNP were maintained after l-NAME or increased K+. In conclusion, this study shows that 1) the attenuated response to PHE in hypothyroidism is not related to an increased production of endothelium-derived relaxing factors NO and EDHF; 2) the response to VC in hypothyroid preparations is insensitive to EDHF blockade; and 3) hypothyroid preparations have a reduced reactivity to the NO donor, and NO-independent vasodilatation remains unaffected.

Estoppel and the protection of expectations

Legal Studies ◽  
1997 ◽  
Vol 17 (2) ◽  
pp. 258-285 ◽  
Author(s):  
Elizabeth Cooke
Keyword(s):  
The Other ◽  
Normal Response ◽  
The Law

Does the law of estoppel remedy reliance loss, or protect and grant expectations? In 1983 it was said that:‘This is a question that the courts must decide once and for all, and … they must not shirk from providing an answer by pretending that that answer will vary according to the facts of each particular case.’This article examines a view about this question which I shall call the ‘reliance loss theory’, which states that the normal response to a successful plea of estoppel is to compensate the claimant's reliance loss rather than to fulfil his expectations; in other words, that the court will, if possible, remedy the detriment he has already suffered in reliance upon what the other has said, without going to the lengths of obliging that other to abide by, or fulfil, what he has led the claimant to believe by his conduct or silence. The reliance loss theory has been presented as a description of what actually happens, but it also appears as an argument for what the law should be.

Cyclic Cushing's syndrome combined with cortisol suppressible, dexamethasone non-suppressible ACTH secretion: a new variant of Cushing's syndrome

1985 ◽  
Vol 110 (3) ◽  
pp. 289-295 ◽  
Author(s):  
Hans-Udo Schweikert ◽  
Horst Lorenz Fehm ◽  
Rudolf Fahlbusch ◽  
Rainer Martin ◽  
Rainer Kolloch ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Normal Tissue ◽  
Plasma Cortisol ◽  
Cushing's Syndrome ◽  
Cortisol Secretion ◽  
Plasma Acth ◽  
Acth Secretion ◽  
Normal Response ◽  
New Variant ◽  
Marked Suppression

Abstract. A 55 year old woman with an unusual form of Cushing's disease was studied. During several periods (periods lasting up to 84 days) evidence of cortisol hypersecretion with cycles occurring every 6 days was found. Suppression of plasma cortisol through orally administered dexamethasone (up to 32 mg per day) could not be achieved either during periods of cyclic cortisol hypersecretion or during apparent remission with normal cortisol secretion. Marked suppression of plasma ACTH was measured in response to an iv infusion of 50 mg cortisol over a period of 55 min whereas a similar test with 2 mg dexamethasone (iv bolus) did not suppress ACTH secretion. Transsphenoidal exploration of the sella revealed a tumour surrounding the anterior pituitary. Examination of the pituitary showed a few tiny tumour structures embedded in normal tissue which could not be removed, when the tumour was resected selectively under preservation of normal appearing tissue. Post-operatively, clinical and chemical remission (normal response to 1 mg dexamethasone) was observed for about 4 months. Thereafter, cortisol hypersecretion occurred again necessitating bilateral adrenalectomy. Our results are compatible with the assumption that normal hypothalamic-pituitary-adrenal suppressibility with cortisol, but not with dexamethasone, was caused by the loss of feedback receptors for dexamethasone in the presence of cortisol receptors in the cells which secrete ACTH or CRF. The combination of cyclic hypercortisolism with dexamethasone non-suppressible Cushing's syndrome has not been reported before and thus represents a new variant of Cushing's syndrome.

scholarly journals Normal Response Curve to Exercise of Relative Cardiac Output Measured with Radioiodinated Serum Albumin

Circulation ◽  
1959 ◽  
Vol 19 (4) ◽  
pp. 590-594 ◽  
Author(s):  
SYLVAN L. WEINBERG ◽  
G. RICHARD GROVE ◽  
ROBERT E. ZIPF ◽  
DAVID C. DANIELS ◽  
JAMES P. MURPHY
Keyword(s):  
Cardiac Output ◽  
Serum Albumin ◽  
Response Curve ◽  
Normal Response
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