Autoradiographic study of3H-lysine uptake by superior cervical and stellate ganglia in prehypertensive spontaneously hypertensive rats

1986 ◽  
Vol 52 (1) ◽  
pp. 299-304 ◽  
Author(s):  
M. Kondo
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Autoradiographic Study ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Stellate Ganglia

Myocardial meta-[125I]iodobenzylguanidine uptake in awake genetically hypertensive rats at different ages: an autoradiographic study

1999 ◽  
Vol 77 (6) ◽  
pp. 398-406 ◽  
Author(s):  
Carole Schwebel ◽  
Andrée Durand ◽  
Diane Godin-Ribuot ◽  
Olivier Provendier ◽  
Pierre Demenge
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Weight Ratio ◽  
Autoradiographic Study ◽  
Mibg Uptake ◽  
Hypertensive Rats ◽  
Heterogeneous Distribution ◽  
Spontaneously Hypertensive ◽  
Wky Rats ◽  
Arterial Blood ◽  
Wistar Kyoto

The purpose of this work was to evaluate changes in myocardial meta-[125I]iodobenzylguanidine ([125I]MIBG) uptake and distribution with age in awake spontaneously hypertensive rats (SHR) with respect to Wistar-Kyoto (WKY) rats. Rats were randomly divided into two groups, one for measuring myocardial [125I]MIBG uptake and distribution 4 h after its injection and the second for evaluating myocardial catecholamine concentrations. Mean arterial blood pressure, cardiac hypertrophy index (heart/body weight ratio), and heart rate were significantly higher with increasing age in SHR compared with matched WKY rats. Myocardial catecholamine concentrations and turnover did not differ between the two strains and were significantly decreased with increasing age. Myocardial [125I]MIBG uptake determined by gamma counting was similar in WKY rats and SHR and did not vary significantly with age when expressed as uptake density. However, in both strains of rats, [125I]MIBG uptake determined by autoradiography was significantly greater at the base of the heart than at the apex and midventricular levels, and the uptake values of young rats were significantly higher than those of older rats. In 21-week-old WKY rats and SHR, the highest [125I]MIBG uptake values were found in the right ventricle. Thus, quantitative autoradiography allowed detection of significant changes in myocardial [125I]MIBG uptake and showed its heterogeneous distribution in the rat heart.Key words: spontaneously hypertensive rats (SHR), Wistar-Kyoto rats, myocardial meta-[125I]iodobenzylguanidine uptake, sympathetic drive.

Sign in / Sign up

Export Citation Format

Share Document