Ultrastructural and functional changes in pancreatic acinar cells during autolysis

1977 ◽  
Vol 24 (1) ◽  
pp. 197-207
Author(s):  
Timo J. Nevalainen ◽  
Jorma Anttinen
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Functional Changes

scholarly journals Mechanisms of damage of acinar pancreatic cells in acute alcohol pancreatitis

2019 ◽  
Vol 16 (1) ◽  
pp. 108-116
Author(s):  
L. A. Mozheiko
Keyword(s):  
Molecular Level ◽  
Early Stage ◽  
Acinar Cells ◽  
Current Data ◽  
Cellular Damage ◽  
Pancreatic Acinar Cells ◽  
Atp Production ◽  
Functional Changes ◽  
Trypsinogen Activation ◽  
Pancreatic Cells

The review analyzes the current data on the main mechanisms of toxic effects of alcohol and its metabolites on pancreatic acinar cells in acute pancreatitis. It is shown that the mechanisms of cellular damage are multicomponent and closely linked by the regulatory factors of the molecular level. At the early stage of the disease, they lead to the following structural and functional changes in acinar cells that promote the premature intracellular trypsinogen activation and autoaggression: sustained rise of cytosolic Ca2+ and excess of mitochondrial matrix Ca2+; destabilization due to lysosomes and zymogen granules; debective autophagy; mitochondrial depolarization; decreased ATP production and necrosis.

Visualization of CCK-evoked exocytic events in rat pancreatic acinar cells

2001 ◽  
Vol 120 (5) ◽  
pp. A24-A24
Author(s):  
H GAISANO ◽  
L TANG ◽  
L SHEU ◽  
W TRIMBLE
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells

Effects of oncogenic K-ras on pancreatic acinar cells In vitro

2001 ◽  
Vol 120 (5) ◽  
pp. A722-A722
Author(s):  
Y BI ◽  
C LOGSDON
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells

Carbon tetrachloride induced ultrastructural alterations in pancreatic acinar cells and in the hepatocytes. Similarities and differences

Toxicology ◽  
1978 ◽  
Vol 11 ◽  
pp. 289-296 ◽  
Author(s):  
Carmen R. De Castro ◽  
Adriana S. Bernacchi ◽  
Elida C. De Ferreyra ◽  
Olga M. De Fends ◽  
José A. Castro
Keyword(s):  
Carbon Tetrachloride ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Ultrastructural Alterations ◽  
Similarities And Differences

scholarly journals Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells

1993 ◽  
Vol 268 (16) ◽  
pp. 12136-12142
Author(s):  
M.P. Lutz ◽  
D.I. Pinon ◽  
L.K. Gates ◽  
S. Shenolikar ◽  
L.J. Miller
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Cholecystokinin Receptor
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