The role of immune pig colostrum, serum and immunoglobulins IgG, IgM, and IgA in local intestinal immunity against enterotoxic strain ofEscherichia coli 055 in germfree piglets

1975 ◽  
Vol 20 (5) ◽  
pp. 433-438 ◽  
Author(s):  
I. Miler ◽  
J. Černá ◽  
J. Teávníček ◽  
J. Rejnek ◽  
J. Kruml
Keyword(s):  
Ofescherichia Coli ◽  
Intestinal Immunity ◽  
Strain Ofescherichia Coli

scholarly journals The role of cGAS/STING in intestinal immunity

2021 ◽  
Author(s):  
Felix Wottawa ◽  
Dora Bordoni ◽  
Nathan Baran ◽  
Philip Rosenstiel ◽  
Konrad Aden
Keyword(s):  
Intestinal Immunity

MO005HIGH LEVELS OF FIVE SPECIFIC FECAL METABOLITES IN IGA NEPHROPATHY PATIENTS SUPPORT THE HYPOTHESIS OF THE INTESTINAL-RENAL AXIS CONNECTION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Claudia Curci ◽  
Fabio Sallustio ◽  
Nada Chaoul ◽  
Angela Picerno ◽  
Gabriella Lauriero ◽  
...  
Keyword(s):  
B Cells ◽  
Iga Nephropathy ◽  
Solid Phase ◽  
Serum Levels ◽  
Intestinal Lumen ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Intestinal Immunity ◽  
Adaptive Immune Cells

Abstract Background and Aims The IgA nephropathy (IgAN) is the most frequent primitive glomerulonephritis. In the last years, the role of mucosal immunity in IgAN, together with that of the gut microbiota in the activation of innate and adaptive immune cells, has gained importance. Particularly interesting is the role of the microbiota and intestinal immunity in IgAN. BAFF and APRIL can be produced by the intestinal epithelium, in response to signals triggered by TLRs once activated by the commensal bacteria present in the intestinal lumen, representing the link between microbiota and intestinal immunity. To date, even if hypothesized, this relationship in IgAN patients has not been investigated. Here, we studied the intestinal-renal axis connections analyzing levels of BAFF, April and intestinal-activated B cells in IgAN patients. Method Serum and fecal samples were collected from 44 IgAN patients, 22 non-IgA glomerulonephritides (controls) and 22 healthy subjects (HS) with similar clinical features. BAFF and APRIL serum levels were measured by ELISA assay. Metabolomic analysis of fecal microbiome was performed using Biochrom 30 series amino acid analyzer and gas-chromatography mass spectrometry/solid-phase microextraction (GC-MS/SPME) analysis. B cell subsets were investigated by FACS. Results IgAN patients had increased serum levels of BAFF cytokine compared to the control group of patients with non-IgA glomerulonephritis and compared with HS (p<0.0001and p=0.012, respectively). We found that serum BAFF levels positively correlated with the levels of 24h-proteinuria in IgAN patients (r2 = 0.2269, p <0.001). We correlated serum BAFF levels with fecal concentration of 5 different metabolites of 30 IgAN patients, which were previously investigated for the fecal microbiota. These organic compounds had been found at significantly higher levels in the feces of IgAN patients compared to HS. Serum BAFF levels positively correlated with the levels of fecal metabolites: 4-(1,1,3,3-tetramethylbutyl) phenol (r2 = 0.2882, p = 0.0027), p-tert-butyl-phenol (r2 = 0.386, p = 0.0003), methyl neopentyl phthalic acid (r2 = 0.3491, p =0.0007), hexadecyl ester benzoic acid (r2 = 0.2832, p =0.003) and furanone A (r2 = 0.1743, p = 0.024). Serum levels of APRIL were significantly increased in IgAN patients respect to control groups (4.49 ± 0.54 vs 2.27 ± 1 ng/ml, p=0.0014). We found a correlation between APRIL and serum creatinine (r2 = 0.159, p =0.04) and eGFR (r2 = 0.2395, p =0.0082), while no correlation was found between APRIL and fecal metabolite levels in IgAN patients. In addition, we found that subjects with IgAN have a significantly higher proportion of circulating Bregs, Memory B cells and IgA secreting-plasmablasts activated at the intestinal level (CCR9+INTB7+) compared to HS. Conclusion The results of our study showed for the first time an important correlation of serum levels of BAFF with intestinal microbiota in patients with IgAN, confirming the hypothesis of the pathogenic role of intestinal mucosal hyperresponsiveness in the IgAN patients. The intestinal-renal axis plays a crucial role in Berger's glomerulonephritis, whose complex pathogenesis may contribute several factors as genetics, pathogens and food.

The Role of Colostral Immunoglobulins in Intestinal Immunity to Enteric Colibacillosis in the Calf

1974 ◽  
Vol 17 (3) ◽  
pp. 290-301 ◽  
Author(s):  
E.F. Logan ◽  
A. Stenhouse ◽  
D.J. Ormrod ◽  
W.J. Penhale
Keyword(s):  
Intestinal Immunity

scholarly journals The role of the macrophage in sentinel responses in intestinal immunity

2010 ◽  
Vol 26 (6) ◽  
pp. 578-582 ◽  
Author(s):  
Shehzad Z Sheikh ◽  
Scott E Plevy
Keyword(s):  
Intestinal Immunity

scholarly journals Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation

2016 ◽  
Vol 10 (12) ◽  
pp. 1417-1427 ◽  
Author(s):  
Nuala R. O’Shea ◽  
Thean S. Chew ◽  
Jenny Dunne ◽  
Rebecca Marnane ◽  
Bahman Nedjat-Shokouhi ◽  
...  
Keyword(s):  
Critical Role ◽  
Intestinal Immunity
Sign in / Sign up

Export Citation Format

Share Document