scholarly journals The role of cGAS/STING in intestinal immunity

2021 ◽  
Author(s):  
Felix Wottawa ◽  
Dora Bordoni ◽  
Nathan Baran ◽  
Philip Rosenstiel ◽  
Konrad Aden
Keyword(s):  
Intestinal Immunity

MO005HIGH LEVELS OF FIVE SPECIFIC FECAL METABOLITES IN IGA NEPHROPATHY PATIENTS SUPPORT THE HYPOTHESIS OF THE INTESTINAL-RENAL AXIS CONNECTION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Claudia Curci ◽  
Fabio Sallustio ◽  
Nada Chaoul ◽  
Angela Picerno ◽  
Gabriella Lauriero ◽  
...  
Keyword(s):  
B Cells ◽  
Iga Nephropathy ◽  
Solid Phase ◽  
Serum Levels ◽  
Intestinal Lumen ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Intestinal Immunity ◽  
Adaptive Immune Cells

Abstract Background and Aims The IgA nephropathy (IgAN) is the most frequent primitive glomerulonephritis. In the last years, the role of mucosal immunity in IgAN, together with that of the gut microbiota in the activation of innate and adaptive immune cells, has gained importance. Particularly interesting is the role of the microbiota and intestinal immunity in IgAN. BAFF and APRIL can be produced by the intestinal epithelium, in response to signals triggered by TLRs once activated by the commensal bacteria present in the intestinal lumen, representing the link between microbiota and intestinal immunity. To date, even if hypothesized, this relationship in IgAN patients has not been investigated. Here, we studied the intestinal-renal axis connections analyzing levels of BAFF, April and intestinal-activated B cells in IgAN patients. Method Serum and fecal samples were collected from 44 IgAN patients, 22 non-IgA glomerulonephritides (controls) and 22 healthy subjects (HS) with similar clinical features. BAFF and APRIL serum levels were measured by ELISA assay. Metabolomic analysis of fecal microbiome was performed using Biochrom 30 series amino acid analyzer and gas-chromatography mass spectrometry/solid-phase microextraction (GC-MS/SPME) analysis. B cell subsets were investigated by FACS. Results IgAN patients had increased serum levels of BAFF cytokine compared to the control group of patients with non-IgA glomerulonephritis and compared with HS (p<0.0001and p=0.012, respectively). We found that serum BAFF levels positively correlated with the levels of 24h-proteinuria in IgAN patients (r2 = 0.2269, p <0.001). We correlated serum BAFF levels with fecal concentration of 5 different metabolites of 30 IgAN patients, which were previously investigated for the fecal microbiota. These organic compounds had been found at significantly higher levels in the feces of IgAN patients compared to HS. Serum BAFF levels positively correlated with the levels of fecal metabolites: 4-(1,1,3,3-tetramethylbutyl) phenol (r2 = 0.2882, p = 0.0027), p-tert-butyl-phenol (r2 = 0.386, p = 0.0003), methyl neopentyl phthalic acid (r2 = 0.3491, p =0.0007), hexadecyl ester benzoic acid (r2 = 0.2832, p =0.003) and furanone A (r2 = 0.1743, p = 0.024). Serum levels of APRIL were significantly increased in IgAN patients respect to control groups (4.49 ± 0.54 vs 2.27 ± 1 ng/ml, p=0.0014). We found a correlation between APRIL and serum creatinine (r2 = 0.159, p =0.04) and eGFR (r2 = 0.2395, p =0.0082), while no correlation was found between APRIL and fecal metabolite levels in IgAN patients. In addition, we found that subjects with IgAN have a significantly higher proportion of circulating Bregs, Memory B cells and IgA secreting-plasmablasts activated at the intestinal level (CCR9+INTB7+) compared to HS. Conclusion The results of our study showed for the first time an important correlation of serum levels of BAFF with intestinal microbiota in patients with IgAN, confirming the hypothesis of the pathogenic role of intestinal mucosal hyperresponsiveness in the IgAN patients. The intestinal-renal axis plays a crucial role in Berger's glomerulonephritis, whose complex pathogenesis may contribute several factors as genetics, pathogens and food.

The Role of Colostral Immunoglobulins in Intestinal Immunity to Enteric Colibacillosis in the Calf

1974 ◽  
Vol 17 (3) ◽  
pp. 290-301 ◽  
Author(s):  
E.F. Logan ◽  
A. Stenhouse ◽  
D.J. Ormrod ◽  
W.J. Penhale
Keyword(s):  
Intestinal Immunity

scholarly journals The role of the macrophage in sentinel responses in intestinal immunity

2010 ◽  
Vol 26 (6) ◽  
pp. 578-582 ◽  
Author(s):  
Shehzad Z Sheikh ◽  
Scott E Plevy
Keyword(s):  
Intestinal Immunity

scholarly journals Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation

2016 ◽  
Vol 10 (12) ◽  
pp. 1417-1427 ◽  
Author(s):  
Nuala R. O’Shea ◽  
Thean S. Chew ◽  
Jenny Dunne ◽  
Rebecca Marnane ◽  
Bahman Nedjat-Shokouhi ◽  
...  
Keyword(s):  
Critical Role ◽  
Intestinal Immunity

scholarly journals Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Phillips-Farfán Bryan ◽  
Carvajal Karla ◽  
Medina-Torres Edgar Alejandro ◽  
Espinosa-Padilla Sara Elva ◽  
Fabrias Gemma ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Response ◽  
Immune System ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Therapeutic Agents ◽  
Intestinal Cells ◽  
Intestinal Immunity ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important players and promising therapeutic targets to control inflammation in IBD. Interestingly, it seems that microorganisms of the normal gut microbiota and probiotics are involved in sphingolipid function. However, there is a great need to investigate the role of SLs as intermediates in the crosstalk between intestinal immunity and microorganisms. This review focuses on recent investigations that describe some mechanisms involved in the regulation of cytokine profiles by SLs. We also describe the importance of gut microbiota in providing signaling molecules that favor the communication between resident bacteria and intestinal cells. This, in turn, modulates the immune response in the bowel and likely in other peripheral organs. The potential of SLs and gut microbiota as targets or therapeutic agents for IBD is also discussed.

scholarly journals What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 406
Author(s):  
Clément Caffaratti ◽  
Caroline Plazy ◽  
Geoffroy Mery ◽  
Abdoul-Razak Tidjani ◽  
Federica Fiorini ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Immune Responses ◽  
Immune Cells ◽  
Causal Effect ◽  
Host Immunity ◽  
Intestinal Immunity ◽  
Host Health ◽  
Membrane Bound ◽  
Insight Into

Trillions of microorganisms, termed the “microbiota”, reside in the mammalian gastrointestinal tract, and collectively participate in regulating the host phenotype. It is now clear that the gut microbiota, metabolites, and intestinal immune function are correlated, and that alterations of the complex and dynamic host-microbiota interactions can have deep consequences for host health. However, the mechanisms by which the immune system regulates the microbiota and by which the microbiota shapes host immunity are still not fully understood. This article discusses the contribution of metabolites in the crosstalk between gut microbiota and immune cells. The identification of key metabolites having a causal effect on immune responses and of the mechanisms involved can contribute to a deeper insight into host-microorganism relationships. This will allow a better understanding of the correlation between dysbiosis, microbial-based dysmetabolism, and pathogenesis, thus creating opportunities to develop microbiota-based therapeutics to improve human health. In particular, we systematically review the role of soluble and membrane-bound microbial metabolites in modulating host immunity in the gut, and of immune cells-derived metabolites affecting the microbiota, while discussing evidence of the bidirectional impact of this crosstalk. Furthermore, we discuss the potential strategies to hear the sound of such metabolite-mediated crosstalk.

scholarly journals Microbiome in Health: Establishment, Metabolism, Immunity and Neuronal Pathway

2020 ◽  
Vol 3 (2) ◽  
pp. 379-383
Author(s):  
Matthew Obaineh Ojezele ◽  
Simon Irikefe Ovuakporaye ◽  
Emmanuel Adesola Adedapo
Keyword(s):  
Human Body ◽  
Gut Microbiome ◽  
Lymphoid Tissue ◽  
Human Microbiome ◽  
Postnatal Period ◽  
Tissue Growth ◽  
Intestinal Immunity ◽  
Human Gut ◽  
Host Genotype

The studies on microbiome encountered a blast, lately, as scientists become mindful of the role of microbiota in the advancement of specifi c kinds of maladies. The human microbiome is described as a community of microorganisms of different taxa colonizing the human body; this includes the metagenomics and metabolomics of these organisms. Humans have customized microbiome in terms of distribution and composition which are partly determined by host genotype as well as the initial colonization which takes place after delivery. The human gut microbiome has a vital infl uence on immunity and how it responds to body signals, which is very important for the lymphoid tissue growth, maintenance, and regulation of intestinal immunity. This review aimed at providing an overview of the role of the human microbiome in health spanning the development of the microbiome in utero to postnatal period. 

scholarly journals The role of dietary gangliosides on immunity and the prevention of infection

2007 ◽  
Vol 98 (S1) ◽  
pp. S68-S73 ◽  
Author(s):  
Ricardo Rueda
Keyword(s):  
Dendritic Cell Maturation ◽  
Individual Species ◽  
Intestinal Immunity ◽  
Mature Milk ◽  
Intestinal Immune System ◽  
Fat Globule ◽  
Prevention Of Infections ◽  
Intestinal Ecology ◽  
Iga Production

Gangliosides are acid glycosphingolipids widely distributed in most vertebrate tissues and fluids. They are present in mammalian milk, where they are almost exclusively associated with the membrane fraction of the fat globule. In human milk, the content and individual distribution of gangliosides changes during lactation, GD3being the most abundant ganglioside in colostrum, while in mature milk, GM3is the major individual species. Gangliosides function as “unintended” target receptors for bacterial adhesion in specific tissues. After oral administration, they can be putative decoys that interfere with pathogenic binding in the intestine, this being the main mechanism by which these compounds can prevent infection. Ganglioside-supplemented infant formula has been reported to modify the intestinal ecology of preterm newborns, increasing theBifidobacteriacontent and lowering that ofEscherichia coli. In addition, the influence of dietary gangliosides on several parameters related to the development of intestinal immune system, such as cytokine and intestinal IgA production, has also been described in animal models. Recently, the influence of GM3and GD3on dendritic cell maturation and effector functionalities has also been reported, suggesting a role for these milk gangliosides, especially GD3, in modulating the process of oral tolerance during first stages of life. In summary, dietary gangliosides may have an important role in the modification of intestinal microflora and the promotion of intestinal immunity development in the neonate, and consequently in the prevention of infections during early infancy.

scholarly journals Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis

2020 ◽  
Vol 319 (6) ◽  
pp. G685-G695
Author(s):  
Pengfei Wu ◽  
Ruofei Zhang ◽  
Mei Luo ◽  
Tianci Zhang ◽  
Lisha Pan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Innate Immunity ◽  
Small Intestine ◽  
Liver Diseases ◽  
Paneth Cell ◽  
Intestinal Immunity ◽  
Cell Functions ◽  
Gut Dysbiosis ◽  
Liver Fibrogenesis

Vitamin D deficiency is coprevalent with various liver diseases, indicating the role of vitamin D in maintaining liver homeostasis. In this study, we observed that the hepatic 25-hydroxylation of VD is critical for intestinal innate immunity through VD signaling in the small intestine for maintaining Paneth cell functions. Conversely, failure of biogenesis of VD in the liver impairs intestinal immunity, leading to gut dysbiosis and endotoxemia, which promotes liver fibrogenesis.

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