scholarly journals Modulation of convulsive threshold of pentylene tetrazole by zinc

1997 ◽  
Vol 12 (1) ◽  
pp. 86-90 ◽  
Author(s):  
N. Khanna ◽  
A. Garg ◽  
K. K. Sharma ◽  
R. Khosla
Keyword(s):  
Convulsive Threshold

Committee on Drugs Attacked

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 952-952
Author(s):  
Leon Oettinger
Keyword(s):  
Clinical Experience ◽  
Extensive Clinical Experience ◽  
Convulsive Threshold

I note Doctor Livingston's comments on the use of amphetamines in epilepsy and the Committee's reply. I would like to support Doctor Livingston's endorsement of the use of amphetamines in epilepsy. He and his colleagues wrote an article in the fifties on their use in petit mal. Laufer and Denhoff also indicated an increase in the convulsive threshold using a metrazol activation in hyperkinetic children. Although the Committee may not be aware of the literature concerning this, many of us who have had extensive clinical experience with epilepsy feel that the amphetamines are of value.

scholarly journals Spontaneous seizures after ECT in a patient medicated with bupropion, sertraline and risperidone

2016 ◽  
Vol 38 (2) ◽  
pp. 111-113 ◽  
Author(s):  
Orlando von Doellinger ◽  
João Pedro Ribeiro ◽  
Ângela Ribeiro ◽  
Catarina Freitas ◽  
Bruno Ribeiro ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Major Depressive Episode ◽  
Slow Release ◽  
Psychotic Symptoms ◽  
Case Description ◽  
Major Depressive ◽  
Spontaneous Seizures ◽  
Clonic Seizures ◽  
Major Depressive Symptoms ◽  
Convulsive Threshold

Abstract Objective: To report a case of post-electroconvulsive therapy spontaneous seizures in a patient medicated with sertraline, bupropion and risperidone. Case description: A 53-year-old woman with recurrent major depression was admitted to our psychiatry department for a major depressive episode of 6 weeks' duration, with psychotic symptoms. She was already on 200 mg/day of sertraline and 2 mg/day of risperidone. After 8 weeks on 200 mg/day of sertraline, 4 mg/day of risperidone and slow release bupropion (titrated to 300 mg/day), with no objective improvements, the decision was taken to initiate a course of 8-10 electroconvulsive therapy (ECT) sessions. Two days after the first treatment, three generalized tonic-clonic seizures occurred within 6 hours. Phenytoin and sodium valproate were added to the patient's daily medication and no further spontaneous seizures were observed. After neurologic assessment and discussion of the case, phenytoin and bupropion were withdrawn at once (two days after the spontaneous seizures) and the decision was taken to resume the ECT treatment. No further spontaneous seizures occurred and, at discharge, the patient exhibited significant improvements and was free from major depressive symptoms. Comments: This report illustrates a case of post-ECT spontaneous seizures that might have been due to a specific pharmacological etiological pathway, namely, bupropion's proconvulsive properties, although both sertraline and risperidone also lower the convulsive threshold.

scholarly journals Scorpion Envenomation of Lactating Rats Decreases the Seizure Threshold in Offspring

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 853
Author(s):  
Marina de Oliveira Rodrigues Barbosa ◽  
Maria Eliza F. do Val de Paulo ◽  
Ana Leonor Abrahão Nencioni
Keyword(s):  
Perinatal Period ◽  
Postnatal Period ◽  
Seizure Threshold ◽  
Long Term Effects ◽  
Crude Venom ◽  
Long Time ◽  
Few Data ◽  
The Relationship ◽  
Convulsive Threshold

Few data are available in the literature describing the long-term effects of envenoming in the perinatal period. In this study, the relationship between envenoming of lactating rats and possible behavioral changes in the mother and in her offspring were investigated. Lactating Wistar rats received a single dose of T. serrulatus crude venom on postnatal days 2 (V2), 10 (V10) or 16 (V16), and had their maternal behavior evaluated. The seizure threshold was evaluated in adulthood offspring. A decrease in maternal care during envenoming was observed in V2 and V10 groups. The retrieval behavior was absent in the V2 group, and a lower seizure threshold in the adult offspring of all groups was observed. During envenoming, mothers stayed away from their offspring for a relatively long time. Maternal deprivation during the early postnatal period is one of the most potent stressors for pups and could be responsible, at least in part, for the decrease in the convulsive threshold of the offspring since stress is pointed to as a risk factor for epileptogenesis. Furthermore, the scorpionic accident generates an intense immune response, and inflammation in neonates increases the susceptibility to seizures in adulthood. Therefore, maternal envenoming during lactation can have adverse effects on offspring in adulthood.

Electroencephalographic Findings in Treatment-Seeking Homosexuals Compared with Heterosexuals: a Controlled Study

1975 ◽  
Vol 127 (1) ◽  
pp. 63-66 ◽  
Author(s):  
R. Papatheophilou ◽  
Sheelah James ◽  
A. Orwin
Keyword(s):  
Controlled Study ◽  
Treatment Seeking ◽  
Initial Series ◽  
Eeg Abnormalities ◽  
Convulsive Threshold

During the course of research into the reorientating of homosexuals routine EEGs were taken to identify patients with low convulsive threshold to exclude them from treatment (aversion). In an initial series of 28 homosexuals 4 showed EEG abnormalities related to organic conditions, but EEGs of the otherwise apparently normal treatment seeking homosexuals showed more marked overbreathing response than would have been expected by chance.

Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit

1995 ◽  
Vol 73 (6) ◽  
pp. 714-717 ◽  
Author(s):  
Zyheir Hasan ◽  
Said Khatib ◽  
Ayman Abu-Laban
Keyword(s):  
Intravenous Administration ◽  
Seizure Threshold ◽  
Intravenous Anesthetics ◽  
Threshold Test ◽  
Dose Dependent Increase ◽  
Convulsive Threshold ◽  
Dose Dependent ◽  
Higher Doses

The purpose of the present study was to examine the effect of intravenous administration of propofol and thiopentone on picrotoxin-induced seizures using the picrotoxin convulsive threshold test in the rabbit. Neither propofol nor thiopentone at a dose of 1.25 mg/kg had any significant effect on picrotoxin seizure threshold. However, at higher doses (2.5, 5, 10 mg/kg) both propofol and thiopentone produced a significant and dose-dependent increase in the picrotoxin convulsive threshold. These findings suggest that propofol is an effective anticonvulsant against picrotoxin-induced seizures in the rabbit.Key words: convulsions, intravenous anesthetics, picrotoxin, propofol, thiopentone.

Effect of CGS-8216 on High-Dose Flurazepam Convulsive Threshold

Pharmacology ◽  
1986 ◽  
Vol 32 (3) ◽  
pp. 131-133 ◽  
Author(s):  
W.M. Bourn ◽  
R.L. Garrett ◽  
K.M. Tolson
Keyword(s):  
High Dose ◽  
Cgs 8216 ◽  
Convulsive Threshold

Effect of Chlorpromazine, Reserpine and Frenquel on Convulsive Threshold

1958 ◽  
Vol 18 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Kathleen Smith ◽  
George A. Ulett ◽  
Laverne Johnson ◽  
Margaret Johnson
Keyword(s):  
Convulsive Threshold
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