scholarly journals Fecal bile acid analysis in healthy Japanese subjects using a lipophilic anion exchanger

1981 ◽  
Vol 16 (6) ◽  
pp. 650-650
Author(s):  
Noritoshi Tanida ◽  
Yutaka Hikasa ◽  
Motonobu Hosomi ◽  
Masamichi Satomi ◽  
Isao Oohama ◽  
...  
Keyword(s):  
Bile Acid ◽  
Anion Exchanger ◽  
Fecal Bile Acid ◽  
Lipophilic Anion ◽  
Japanese Subjects

Analysis of bile acid glucuronides in urine: group separation on a lipophilic anion exchanger

1982 ◽  
Vol 123 (3) ◽  
pp. 275-285 ◽  
Author(s):  
A. Stiehl ◽  
R. Raedsch ◽  
G. Rudolph ◽  
P. Czygan ◽  
S. Walker
Keyword(s):  
Bile Acid ◽  
Anion Exchanger ◽  
Group Separation ◽  
Lipophilic Anion

Altered Fecal Bile Acid Pattern in Patients with Inflammatory Bowel Disease

Digestion ◽  
1986 ◽  
Vol 35 (4) ◽  
pp. 189-198 ◽  
Author(s):  
W. Kruis ◽  
H.-D. Kalek ◽  
F. Stellaard ◽  
G. Paumgartner
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bile Acid ◽  
Bowel Disease ◽  
Fecal Bile Acid ◽  
Inflammatory Bowel

scholarly journals 4444 The effect of early life antibiotics on gut microbiome and fecal bile acid concentrations in children

2020 ◽  
Vol 4 (s1) ◽  
pp. 146-147
Author(s):  
Alain Jesus Benitez ◽  
Jeffrey S. Gerber ◽  
Ceylan Tanes ◽  
Kyle Bittinger ◽  
Elliot S. Friedman ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Bile Acid ◽  
Early Life ◽  
Bacterial Community Composition ◽  
Antibiotic Use ◽  
First Year ◽  
Antibiotic Exposure ◽  
Fecal Bile Acid ◽  
Gi Symptoms ◽  
First Year Of Life

OBJECTIVES/GOALS: The current proposal seeks to investigate the effect of early life antibiotic use in the development of functional gastrointestinal (GI) disorders. We propose that infants exposed to antibiotics will present with gut microbial dysbiosis, changes in fecal bile acid concentrations and develop more GI symptoms compared to unexposed children. METHODS/STUDY POPULATION: We analyzed fecal samples from 174 subjects at 12 months of age, of whom 52 were exposed to antibiotics in their first year of life. Of these, 33 subjects were sampled again at 24 months of age. DNA from 200mg of frozen stool (−80C) was isolated with the Qiagen DNeasy PowerSoil kit. Shotgun libraries were generated using the NexteraXT kit and sequenced on the Illumina HiSeq 2500 using 2x125 bp chemistry. Sequence data were analyzed using the Sunbeam metagenomics pipeline. The abundance of bacteria was estimated using Kraken version 2.0.8. Fecal bile acids will be quantified by liquid chromatography–mass spectrometry (LC-MS). RESULTS/ANTICIPATED RESULTS: Overall bacterial community composition at 12 or 24 months was not associated with antibiotic exposure (PERMANOVA test, Bray-Curtis distance). An increase in Enterobacteriaceae, in particular Escherichia coli, is a signature of antibiotic-induced dysbiosis, but also of early infant gut. Children with antibiotic exposure had slightly higher abundance of Escherichia coli compared to those with no exposure (p = 0.03). At 24 months, the abundance of Bacteroides caccae, a commensal gut species, was decreased for children exposed to antibiotics in the first year of life (fdr = 0.02). We will perform further analysis of bile acid modifying bacteria, fecal bile acid concentrations and correlate to GI symptoms. DISCUSSION/SIGNIFICANCE OF IMPACT: Our findings suggest a significant but nuanced impact of early life antibiotic use on the composition of the gut microbiota. The association of antibiotic exposure with B. caccae and E. coli warrant further attention in the context of the rapidly developing early-life microbiome. CONFLICT OF INTEREST DESCRIPTION: The authors declare no conflicts of interest relevant to this work.

scholarly journals Hydroxypropyl-Modified Potato Starch Increases Fecal Bile Acid Excretion in Rats

1998 ◽  
Vol 128 (5) ◽  
pp. 848-854 ◽  
Author(s):  
Kiyoshi Ebihara ◽  
Rumiko Shiraishi ◽  
Kazuhiro Okuma
Keyword(s):  
Bile Acid ◽  
Potato Starch ◽  
Fecal Bile Acid ◽  
Acid Excretion ◽  
Bile Acid Excretion

Fecal Bile Acid Concentration in Distance Runners

1991 ◽  
Vol 12 (06) ◽  
pp. 533-536 ◽  
Author(s):  
W. Sutherland ◽  
E. Nye ◽  
D. Macfarlane ◽  
M. Robertson ◽  
S. Williamson
Keyword(s):  
Bile Acid ◽  
Acid Concentration ◽  
Fecal Bile Acid ◽  
Distance Runners ◽  
Bile Acid Concentration

scholarly journals Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations

2016 ◽  
Vol 9 (7) ◽  
pp. 589-597 ◽  
Author(s):  
Elizabeth T. Jacobs ◽  
Mark R. Haussler ◽  
David S. Alberts ◽  
Lindsay N. Kohler ◽  
Peter Lance ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bile Acid ◽  
Vitamin D Metabolites ◽  
Fecal Bile Acid
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