scholarly journals Effect of selenium supplementation on some blood biochemical parameters in male rats

1995 ◽  
Vol 47 (1-3) ◽  
pp. 343-347 ◽  
Author(s):  
A. M. Viegas Crespo ◽  
M. J. Lança ◽  
S. Vasconcelos ◽  
V. Andrade ◽  
H. Rodrigues ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Selenium Supplementation ◽  
Male Rats ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical

Melatonin Improves Blood Biochemical Parameters and DNA Integrity in the Liver and Kidney of Hyperthyroid Male Rats

2020 ◽  
Keyword(s):  
Body Weight ◽  
Dna Fragmentation ◽  
Biochemical Parameters ◽  
Mature Male ◽  
Male Rats ◽  
Dna Integrity ◽  
Tissue Samples ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Liver And Kidney

The present study was carried out to investigate and compare the effect of hyperthyroidism either alone or in combination with melatonin on some blood biochemical parameters and DNA integrity in liver and kidney of male rats. For this purpose 75 mature male rats weighing 120-140g were randomly divided into five groups (control, hyperthyroid, hyperthyroid plus 1, 5 or 10 mg/kg bwt of melatonin, respectively). Hyperthyroidism was experimentally induced by daily I/P injection of L-thyroxine (0.2 mg/kg body weight). The melatonin treated groups were injected with the same dose of L-thyroxine followed by I/P injection of melatonin (1, 5 or 10 mg/kg, respectively). The study was carried out for 21 days. The last blood and tissue samples were collected one day after the end of the last injection (on the 22nd day). The results revealed that hyperthyroidism significantly increased the levels of urea and the activities of GOT, GPT, ALP as well as the percentage of DNA fragmentation in the liver and kidney. At the same time hyperthyroidism induced a significant decrease in level of creatinine. Treatment with the 3 doses of melatonin completely ameliorated the hyperthyroidism- induced increase in GPT and ALP, while 5 and 10 mg could completely counteract the hyperthyroidism- induced increase in urea and only the 10 mg melatonin could ameliorate the hyperthyroidism-induced increase in GOT activity. It is concluded that melatonin can ameliorate the hyperthyroidism-induced disturbance in blood biochemical parameters and DNA fragmentation.

scholarly journals Influence of carbon disulfide intoxication on blood biochemical parameters and their correction by plant phenolic compounds in experiment

2021 ◽  
pp. 15-25
Author(s):  
E.S. Drugova ◽  
◽  
N.F. Kushnerova ◽  
V.Yu. Merzlyakov ◽  
S.E. Fomenko ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Carbon Disulfide ◽  
Biochemical Parameters ◽  
Antioxidant Defense System ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Radical Processes

Introduction. Phenolic compounds that are part of a variety of phytopreparations have an anti-radical and antioxidant effect. Aim. Studying the influence of carbon disulfide intoxication on the rat blood biochemical parameters and the possibility of their correction with natural plant phenolic compounds from viburnum. Materials and methods. The experiment was conducted on white Wistar male rats. Carbon disulfide intoxication (concentration 2.0 mg/m3) was implemented in a special exposure chamber. The animals were divided into 5 groups: the 1st group was control (intact rats); the 2nd group was carbon disulfide intoxication for 3 weeks; the 3rd group was carbon disulfide intoxication for 3 weeks, followed by discontinuation for 7 days; the 4th group was carbon disulfide intoxication for 3 weeks, followed by administration of the viburnum extract for 7 days; the 5th group was carbon disulfide intoxication for 3 weeks, followed by silymarin administration for 7 days. The drugs were administered at a dose of 100 mg of total phenols per kilogram of animal weight. Results. Carbon disulfide intoxication was accompanied by the development of intense hypercholesterolemia; an increase in the fraction of low-density lipoproteins with simultaneous decrease in high-density lipoproteins in blood serum. There was an increase in the level of malondialdehyde, decrease in the superoxide dismutase activity and reduced glutathione amount, which indicates the depletion of the body’s antioxidant defense system. During the withdrawal period of carbon disulfide intoxication for 7 days, the blood biochemical parameters did not recover, which indicates the preservation of free-radical processes. The administration of the viburnum extract and the comparison drug, silymarin, was accompanied by a recovery to the control group level of blood biochemical parameters after carbon disulfide intoxication. Conclusion. The toxic effect of carbon disulfide causes a change in the studied blood biochemical parameters. The administration of the viburnum extract and silymarin was accompanied by their restoration to the level of the control group, but a more pronounced effect was observed in the viburnum extract due to the presence of oligomeric forms of polyphenols in its composition.

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