Studies on hepatic excretion and metabolism of dyes (V) Relative storage capacity and maximal biliary transport of ICG in hepatic disease

1968 ◽  
Vol 3 (1) ◽  
pp. 408-408
Author(s):  
S. Murakami ◽  
T. Namihisa ◽  
T. Kanai ◽  
K. Kinjo ◽  
M. Nambu ◽  
...  
Keyword(s):  
Storage Capacity ◽  
Hepatic Disease ◽  
Relative Storage Capacity

scholarly journals Closed Adsorption Heat Storage—A Life Cycle Assessment on Material and Component Levels

Energies ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 3421 ◽  
Author(s):  
Björn Nienborg ◽  
Tobias Helling ◽  
Dominik Fröhlich ◽  
Rafael Horn ◽  
Gunther Munz ◽  
...  
Keyword(s):  
Life Cycle ◽  
Storage Capacity ◽  
Heat Storage ◽  
Operating Conditions ◽  
Assessment Criterion ◽  
Component Level ◽  
Reference Case ◽  
Relative Storage Capacity ◽  
Auxiliary Material ◽  
And Performance

Closed adsorption storages have been investigated in several projects for heat storage in building applications with focus on energy density and performance. This study complements this research with the assessment of the environmental impacts over the life cycle. Global warming potential (GWP) was chosen as the assessment criterion. Selected sorption materials in combination with water as the refrigerant were analyzed first by themselves and then embedded in a generic storage configuration. Sensible storage in water served as the reference benchmark. Results on material and component level showed that the relative storage capacity compared to water under realistic operating conditions reached values of below 4 and 2.5, respectively, in the best cases. Since the effort for producing the sorbents as well as the auxiliary material demand for assembling storage components was significantly higher than in the reference case, the specific environmental impact per storage capacity also turned out to be ~2.5 to ~100 times higher. We therefore suggest focusing sorption storage research on applications that (a) maximize the utilization of the uptake of sorbents, (b) do not compete with water storages, and (c) require minimal auxiliary parts.

An Evaluation of Bilirubin Kinetics with Respect to the Diagnosis of Gilbert's Syndrome

1978 ◽  
Vol 54 (5) ◽  
pp. 539-547
Author(s):  
L. Okolicsanyi ◽  
O. Ghidini ◽  
R. Orlando ◽  
S. Cortelazzo ◽  
G. Benedetti ◽  
...  
Keyword(s):  
Storage Capacity ◽  
Hepatic Clearance ◽  
Normal Subjects ◽  
Tolerance Test ◽  
Gilbert’S Syndrome ◽  
Transfer Rates ◽  
Essentially Normal ◽  
Gilbert's Syndrome ◽  
Relative Storage Capacity ◽  
Kinetics Of

1. The kinetics of the plasma disappearance of bilirubin (2 mg/kg intravenously) were studied in 106 patients with Gilbert's syndrome and in 13 normal subjects. 2. All patients had significant decreases in hepatic bilirubin clearance and transfer rates from plasma to liver, resulting in increased values for plasma retention at 4 h. The calculated value for unconjugated bilirubin production was normal in 40% of patients and increased in the remainder. 3. In 29 of the Gilbert's patients their bromosulphthalein kinetics were studied 1 week before the bilirubin test. These results were essentially normal and it was concluded that the hepatic clearance mechanisms for bilirubin and bromosulphthalein are different. 4. In 10 patients the bilirubin transport maximum (Tm) was found to be low whereas the relative storage capacity (S) was normal. Phenobarbitone treatment in four patients resulted in an increase in Tm, and S decreased in two patients and remained unchanged in the other two. 5. These results support the hypothesis that there are several variants of Gilbert's syndrome and that the bilirubin tolerance test is a useful diagnostic test.

Determination of sulfobromophthalein excretion in rabbits

1988 ◽  
Vol 254 (6) ◽  
pp. R1043-R1046
Author(s):  
J. M. Quale ◽  
N. V. Bergasa ◽  
L. J. Mandel
Keyword(s):  
Storage Capacity ◽  
Simple Technique ◽  
Biliary Tree ◽  
Hepatic Uptake ◽  
Direct Measurements ◽  
Relative Storage Capacity ◽  
Surgical Cannulation

The excretion of sulfobromophthalein (BSP) is determined by hepatic uptake (storage capacity) and secretion (transport maximum). We calculated the BSP excretion data in six rabbits by measuring the rate of rise of BSP at various infusion rates. The relative storage capacity was determined to be 0.34 +/- 0.13 mg.mg-1.dl-1.kg-1. The transport maximum was calculated to be 0.91 +/- 0.12 mg.min-1.kg-1. These results compare closely with previously reported results using more direct measurements that require anesthesia and surgical cannulation of the biliary tree. Repeated studies were easily performed. Our method provides a reliable and simple technique to study the effects of various conditions or substances on BSP excretion in conscious, unanesthetized rabbits.

scholarly journals Spatial distribution of bottom sediment deposits in water reservoirs at Zesławice

2009 ◽  
Vol 41 (1) ◽  
pp. 49-56
Author(s):  
Bogusław Michalec ◽  
Karol Pęczek ◽  
Mateusz Strutyński
Keyword(s):  
Spatial Distribution ◽  
Vertical Distribution ◽  
Bottom Sediment ◽  
Storage Capacity ◽  
Measurement Data ◽  
Relative Volume ◽  
Water Reservoirs ◽  
Sediment Deposits ◽  
Relative Storage Capacity ◽  
Comparable Period

Spatial distribution of bottom sediment deposits in water reservoirs at Zesławice Spatial distributions of bottom sediment deposits in two small water reservoirs located on the River Dłubnia at Zesławice is presented in this paper. The distribution was elaborated according to Dendy's method on the basis of results of silting measurements performed in the 2005. Horizontal and vertical distribution of sediment deposits was shown as relation between the relative volume of deposited sediments (Sh/S) and relative storage capacity of the reservoir (Vh/V); the vertical distribution of sediment deposits was presented as relation between the relative volume of deposited sediments (Sv/S) and relative reservoir depth (D/Dm). On the basis of performed analysis of horizontal distributions of sediment deposits it was stated that in the main reservoir at Zesławice 58% of the sediment trapped in the reservoir was accumulated in the inflow (upstream part of the reservoir, whose relative volume is 0.25). In the inflow section of the assistant reservoir of relative storage capacity equal 0.22 only 29% of the sediment was deposited. Comparing curves of horizontal sediment deposits distribution in the main reservoir in its inflow part according to measurement data from the 2005 and 1986 i.e. from a comparable period of operation before desilting and building of an assistant reservoir it was stated that relative volumes of sediment trapped after desilting are over 40% higher than before desilting. In a comparable period of operation before desilting (measurement in the 1983) and after desilting (measurements in the 2005) i.e. after seventeen and sixteen years respectively in the main reservoir the accumulated sediments formed an isle - the value Sv/S equaling 0.09 for D/Dm equal 0 in consequence of a change of hydraulic conditions of water and sediment flow - due to a part of inflowing water of the River Dłubnia being directed to the assistant reservoir.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Total Solids, Fat and Nitrogen in the Feces: V. A Study of Patients With Primary Parenchymatous Hepatic Disease

1950 ◽  
Vol 16 (1) ◽  
pp. 140-150 ◽  
Author(s):  
John B. Gross ◽  
Mandred W. Comfort ◽  
Eric E. Wollaeger ◽  
Marschelle H. Power
Keyword(s):  
Hepatic Disease ◽  
Total Solids

Anemia of Hepatic Disease Studied with Radiochromium

1960 ◽  
Vol 38 (3) ◽  
pp. 324-331 ◽  
Author(s):  
Madison J. Cawein ◽  
Albert B. Hagedorn ◽  
Charles A. Owen
Keyword(s):  
Hepatic Disease

The Origin of Elevation of Serum Alkaline Phosphatase in Hepatic Disease

1962 ◽  
Vol 42 (4) ◽  
pp. 431-438 ◽  
Author(s):  
Stanton G. Polin ◽  
Mitchell A. Spellberg ◽  
Lloyd Teitelman ◽  
Makoto Okumura
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Hepatic Disease
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