Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers

1991 ◽  
Vol 26 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Akira Terano ◽  
Ryo Nakada ◽  
Hiroyuki Mutoh ◽  
Hideyuki Hiraishi ◽  
Shinichi Ota ◽  
...  
Keyword(s):  
Cell Line ◽  
Tumor Markers ◽  
Cell Cancer ◽  
Signet Ring Cell ◽  
Established Cell Line ◽  
Signet Ring ◽  
Established Cell ◽  
Ring Cell

scholarly journals Establishment and characterization of GCSR1, a multi-drug resistant signet ring cell gastric cancer cell line

2015 ◽  
Vol 46 (6) ◽  
pp. 2479-2487 ◽  
Author(s):  
XIN XU ◽  
LI-JUAN QIAN ◽  
XING-YUN SU ◽  
KUI-FENG HE ◽  
KE-TAO JIN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Signet Ring Cell ◽  
Drug Resistant ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Yang Shu ◽  
Weihan Zhang ◽  
Qianqian Hou ◽  
Linyong Zhao ◽  
Shouyue Zhang ◽  
...  
Keyword(s):  
Cell Cancer ◽  
Prognostic Significance ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Primary signet ring cell carcinoma of colon: Retrospective analysis of VACCR database.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 58-58 ◽  
Author(s):  
R. Thota ◽  
T. Tashi ◽  
W. Gonsalves ◽  
V. Murukesan ◽  
P. Townley ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Mucinous Adenocarcinoma ◽  
Cell Cancer ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Lymph Node Status ◽  
Signet Ring ◽  
Ring Cell ◽  
Carcinoma Of Colon

58 Background: Signet ring cell carcinoma accounts for less than 1% of all colon cancers. We examined the clinical pathological features and prognosis of signet ring cell carcinoma of colon and compare it with mucinous and non-mucinous adenocarcinoma of colon. Methods: A total of 206 patients diagnosed with signet ring cell carcinoma from 1995 to 2009 were identified from the VA Central Cancer Registry (VACCR) database. Age, race, histology, grade, lymph node status, stage and type of treatment received data were collected. Results: Out of 206 patients, 173 (83.9%) were white, 31 (15%) were black, and 2 patients were listed as unknown. Median age of diagnosis was 67 years as compared to 70 years for both mucinous and non-mucinous adenocarcinoma of colon. Pathological T-stages were as follows: T1 = 2.9%, T2=5.3%, T3=33.9%, T4= 25.7%, and unknown 32%. Of the total, 22.3% were located in caecum, 21.8% in ascending colon, 15.5% in sigmoid colon, 7.7% in appendix and hepatic flexure of colon, 11.1% in transverse colon, 2.9% in splenic flexure and 4.4% in descending colon. 33.5% were lymph node positive, 34.6% were lymph node negative, and 31.8% were unknown. Histologically grade 3 (55.4%) was most commonly reported followed by grade 2 (7.3%), grade 1 (2.5%), grade 4 (1.9%)and in 33% grade was unknown. 41.3% patients received only surgery while 34% received surgery with adjuvant chemotherapy, 7.3% received chemotherapy alone and 7.8% patients received either chemotherapy, radiation or hormonal therapy alone, 9% did not receive any therapy. 1 year, 3 year and 5 year survivals for signet ring cell cancer compared to adeno carcinoma was 60% vs 80%, 33% vs 60%, and 24% vs 47% respectively. Median survival of signet ring cell carcinoma compared to mucinous and non mucinous adenocarcinoma was 19 months, 48 months and 62 months respectively. Conclusions: Signet ring cell carcinoma of colon has poor survival rates than the other histological subtypes. Signet ring cell carcinoma presents at an earlier age, higher tumor grade and advanced stage at diagnosis when compared to mucinous and non-mucinous adenocarcinoma of colon. Due to rarity of this disease further multi-institute studies are required for in-depth understanding and analysis of this disease. No significant financial relationships to disclose.

scholarly journals Rapidly declining trend of signet ring cell cancer of the stomach may parallel the infection rate of Helicobacter pylori

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hiroshi Ohyama ◽  
Dai Yoshimura ◽  
Yosuke Hirotsu ◽  
Kenji Amemiya ◽  
Hiroyuki Amano ◽  
...  
Keyword(s):  
Infection Rate ◽  
Cell Cancer ◽  
Signet Ring Cell ◽  
Infection Prevalence ◽  
Gastric Tissue ◽  
Antibody Testing ◽  
Signet Ring ◽  
Ring Cell ◽  
H Pylori ◽  
Over Time

Abstract Background Studies indicate that gastric cancer (GC) incidence has decreased, whereas signet ring cell carcinoma (SRC) incidence has increased. However, recent trends in GC incidence are unclear. We used our hospital cancer registry to evaluate the changes in the incidence of GC, SRC, and non-SRC (NSRC) over time in comparison to changes in the H. pylori infection rates over time. Methods We identified 2532 patients with GC enrolled in our registry between January 2007 and December 2018 and statistically analyzed SRC and NSRC incidence. The H. pylori infection rate in patients with SRC was determined by serum anti-H. pylori antibody testing, urea breath test, biopsy specimen culture, and immunohistochemical analysis (IHC) of gastric tissue. Additionally, genomic detection of H. pylori was performed in SRCs by extracting DNA from formalin-fixed paraffin-embedded gastric tissue and targeting 16S ribosomal RNA of H. pylori. Results Overall, 211 patients had SRC (8.3%). Compared with patients with NSRC, those with SRC were younger (P <  0.001) and more likely to be female (P <  0.001). Time series analysis using an autoregressive integrated moving average model revealed a significant decrease in SRC (P <  0.001) incidence; NSRC incidence showed no decline. There was no difference in H. pylori infection prevalence between the SRC and NSRC groups. IHC and genomic methods detected H. pylori in 30 of 37 (81.1%) SRCs. Conclusions Reduction in H. pylori infection prevalence may be associated with the decrease in the incidence of SRC, which was higher than that of NSRC.

scholarly journals Molecular Characterization of Colorectal Signet-Ring Cell Carcinoma Using Whole-Exome and RNA Sequencing

2018 ◽  
Vol 11 (4) ◽  
pp. 836-844 ◽  
Author(s):  
Jae-Yong Nam ◽  
Bo Young Oh ◽  
Hye Kyung Hong ◽  
Joon Seol Bae ◽  
Tae Won Kim ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Rna Sequencing ◽  
Molecular Characterization ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Whole Exome ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet ring cell cancer of Ampulla of Vater—first ever case reported in a teenager and a review of literature

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132110077
Author(s):  
Asad Ali Kerawala ◽  
Abid Jamal ◽  
Lubna Saleem
Keyword(s):  
Cell Cancer ◽  
Ampulla Of Vater ◽  
Signet Ring Cell ◽  
Significant Past Medical History ◽  
Whipple’S Procedure ◽  
Signet Ring ◽  
Upper Gi Endoscopy ◽  
Ring Cell ◽  
Upper Abdominal ◽  
Optimum Management

Ampullary cancers are rare accounting for 0.2% of all gastrointestinal cancers. Signet ring is a rare variant of adenocarcinoma, characterized by having more than 50% of mucin secreting cells and clinically having a worse prognosis. We present the case of a teenage girl with this tumor, the youngest ever reported in medical literature. An 18 years old girl with no significant past medical history presented to our clinic with symptoms of upper abdominal pain and jaundice. Her upper GI endoscopy showed an ampullary lesion which was biopsied—diagnosing it as adenocarcinoma. She underwent a pancreato-duodenectomy (Whipple’s procedure) with Child’s reconstruction and a feeding jejunostomy. Her final histopathology report was documented as infiltrating adenocarcinoma of Signet Ring variety arising from the Ampulla of Vater. Being such a rare entity, there is a lack of randomized trials advising the optimum treatment for such cases. Till then anecdotal experiences will drive the optimum management of this rare disease.

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