Subdiaphragmatic vagotomy abolishes increase in ornithine decarboxylase activity of rat duodenal mucosa after ischemia-reperfusion in superior mesenteric artery

1993 ◽  
Vol 28 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Hisao Mori ◽  
Ryuichi Iwakiri ◽  
Jun-ichi Tanaka ◽  
Masahiro Hirano ◽  
Takanori Koyama ◽  
...  
Keyword(s):  
Superior Mesenteric Artery ◽  
Ornithine Decarboxylase ◽  
Mesenteric Artery ◽  
Ischemia Reperfusion ◽  
Duodenal Mucosa ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Subdiaphragmatic Vagotomy

scholarly journals Ornithine decarboxylase activity in chick duodenum induced by 1 α, 25-dihydroxycholecalciferol

1981 ◽  
Vol 195 (3) ◽  
pp. 685-690 ◽  
Author(s):  
T Shinki ◽  
N Takahashi ◽  
C Miyaura ◽  
K Samejima ◽  
Y Nishii ◽  
...  
Keyword(s):  
Vitamin D ◽  
Enzyme Activity ◽  
Ornithine Decarboxylase ◽  
Calcium Absorption ◽  
Duodenal Mucosa ◽  
Decarboxylase Activity ◽  
Absorption Mechanism ◽  
Deficient Diet ◽  
Ornithine Decarboxylase Activity ◽  
Hormone Administration

The effect of cholecalciferol and its metabolites on ornithine decarboxylase activity was investigated in the duodenal mucosa of vitamin D-deficient chicks. The duodenal ornithine decarboxylase activity decreased in animals fed a vitamin D-deficient diet and its retarded activity was increased dose-dependently by a single injection of cholecalciferol. Among various metabolites of cholecalciferol tested, 1 alpha, 25-dihydroxycholecalciferol [ 1 alpha, 25 (OH)2D3] was the most potent stimulator. Stimulation of the enzyme activity was detected as early as 2h after intravenous administration of 1 alpha, 25 (OH)2D3 and a maximal value was attained at 6 h. The maximal value was 27 times higher than the control. In addition, treatment with 1 alpha 25 (OH)2D3 affected the duodenal content of polyamines. The content of putrescine increased to a value of three times that of the control 6 h after the hormone administration. The spermidine content did not change appreciably. The enhancement of duodenal ornithine decarboxylase activity by 1 alpha, 25 (OH)2D3 occurred in parallel with the enhancement of calcium absorption, which was first detected 3 h after the hormone administration. The enhancement appeared to be tissue-specific. It was observed in every intestinal segment, but was highest in the duodenum. Enzyme activity in other tissues was not influenced appreciably by 1 alpha, 25 (OH)2D3. These results clearly indicate that the duodenal biosynthesis of polyamines is regulated by 1 alpha, 25 (OH)2D3, suggesting the possibility that duodenal ornithine decarboxylase may be involved in the calcium absorption mechanism.

Stimulatory signals from the central nervous system for ornithine decarboxylase activity in the rat duodenal mucosa

1995 ◽  
Vol 2 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Kazuma Fujimoto ◽  
Hidesuke Morita ◽  
Chika Matsunaga ◽  
Shin-ichi Ogata ◽  
Noriaki Furukawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ornithine Decarboxylase ◽  
Duodenal Mucosa ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
The Central Nervous System

Effect of vagotomy on ornithine decarboxylase activity in rat duodenal mucosa

1993 ◽  
Vol 265 (6) ◽  
pp. G1016-G1020 ◽  
Author(s):  
J. Tanaka ◽  
K. Fujimoto ◽  
T. Sakata ◽  
T. Fujimoto ◽  
S. Tsunada ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Dark Period ◽  
Duodenal Mucosa ◽  
Feeding Pattern ◽  
Jejunal Mucosa ◽  
Decarboxylase Activity ◽  
Time Points ◽  
The Third ◽  
Subdiaphragmatic Vagotomy ◽  
The Central Nervous System

The aim of this study was to determine whether the circadian rhythm of ornithine decarboxylase (ODC) activity in rat small intestine is controlled by factors other than luminal nutrients. ODC activity in duodenal and jejunal mucosa of rats fed ad libitum was measured at four time points (0500, 1100, 1700, 2300 h; light period: 0800-2000 h). ODC activity in the jejunum increased in the dark period, which is when rats normally eat. In contrast, ODC activity in the duodenum began to increase at 1700 h, which is when rats do not normally eat, as indicated by the recorded feeding pattern. The increase in ODC activity in the duodenum at 1700 h, but not at other time points, was abolished by subdiaphragmatic vagotomy, whereas vagotomy had no effect on the feeding pattern of rats. Subdiaphragmatic vagotomy had no effect on ODC activity in the jejunum. ODC activity in the duodenum increased following glycoprivation of the central nervous system induced by infusion of 2-deoxyglucose into the third cerebroventricle. These results indicate that the increase in duodenal ODC activity at 1700 h is due to a signal from the upper brain structure through the vagal nerve and not to luminal nutrient factors.

Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion

1995 ◽  
Vol 40 (4) ◽  
pp. 717-721 ◽  
Author(s):  
Kazuma Fujimoto ◽  
Yasushi Sakata ◽  
Seiji Tsunada ◽  
Takanori Koyama ◽  
Hidesuke Morita ◽  
...  
Keyword(s):  
Ornithine Decarboxylase ◽  
Intestinal Mucosa ◽  
Ischemia Reperfusion ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity

Ornithine Decarboxylase Activity in Cultured Endothelial Cells Stimulated by Serum, Thrombin and Serotonin

1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro
Keyword(s):  
Endothelial Cells ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Aortic Endothelial Cells ◽  
Ornithine Decarboxylase Activity ◽  
Rate Limiting Step ◽  
Bovine Aortic Endothelial Cells ◽  
Limiting Step ◽  
Rate Limiting ◽  
Serum Serotonin

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.

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