Factors affecting serum levels of CA 19-9 with special reference to benign hepatobiliary and pancreatic diseases

1986 ◽  
Vol 21 (5) ◽  
pp. 491-498 ◽  
Author(s):  
Norio Sawabu ◽  
Yasuhiro Takemori ◽  
Daishu Toya ◽  
Manabu Yoneshima ◽  
Hisashi Kidani ◽  
...  
2018 ◽  
Vol 24 (24) ◽  
pp. 2876-2882 ◽  
Author(s):  
Kailash Prasad

Cardiovascular diseases (CVD) may be mediated through increases in the cardiovascular risk factors. Hemoglobin A1c (HbA1c) also called glycated hemoglobin is presently used for the diagnosis and management of diabetes. It has adverse effects on cardiovascular system. This review deals with its synthesis and effects on the cardiovascular system. The serum levels of HbA1c have been reported to be affected by various factors including, the lifespan of erythrocytes, factors affecting erythropoiesis, agents interfering glycation of Hb, destruction of erythrocytes, drugs that shift the formation of Hb, statins, and drugs interfering the HbA1c assay. Levels of HbA1c are positively correlated with serum glucose and advanced glycation end products ( AGE), but no correlation between AGE and serum glucose. AGE cannot replace HbA1c for the diagnosis and management of diabetes because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days. HbA1c is positively associated with CVD such as the carotid and coronary artery atherosclerosis, ischemic heart disease, ischemic stroke and hypertension.HbA1c induces dyslipidemia, hyperhomocysteinemia, and hypertension, and increases C-reactive protein, oxidative stress and blood viscosity that would contribute to the development of cardiovascular diseases. In conclusion, HbA1c serves as a useful marker for the diagnosis and management of diabetes. AGE cannot replace HbA1c in the diagnosis and management of diabetes. There is an association of HbA1c with CVD which be mediated through modulation of CVD risk factors.


Neurosurgery ◽  
2003 ◽  
Vol 52 (1) ◽  
pp. 122-126 ◽  
Author(s):  
Tomosato Yamazaki ◽  
Kiyoyuki Yanaka ◽  
Hiroaki Sato ◽  
Kazuya Uemura ◽  
Atsuro Tsukada ◽  
...  

2021 ◽  
Vol 10 (4) ◽  
pp. 210-215
Author(s):  
Musab Ghaderi ◽  
Arman Azadi ◽  
Azad Rahmani ◽  
Zohreh Sanaat ◽  
Hosein Nazemiyeh ◽  
...  

Introduction: Cancer-related fatigue (CRF) is one of the major problems experienced by cancer patients. Identifying the prevalence and factors associated with CRF may be effective in designing appropriate interventions to reduce this problem. This study aimed to examine the prevalence of CRF and its related factors among Iranian cancer survivors. Methods: The samples of this descriptive cross-sectional study included 131 cancer survivors referred to outpatient clinic of Shahid Gazi Hospital affiliated to Tabriz University of Medical Sciences. Brief fatigue inventory (BFI) questionnaire was used for data collection. The data were analyzed using SPSS software version 13, descriptive statistics, and regression analysis. Results: The mean (SD) fatigue score was 6.41 (1.68) and 89% of survivors reported that they had suffered from CRF. The factors affecting CRF included blood pressure, diabetes mellitus, anemia, serum levels of blood urea nitrogen (BUN), marital status, type of cancer, and physical activity. Conclusion: High level of CRF in cancer survivors requires special attention and designing effective interventions through considering the identified factors associated with CRF.


1987 ◽  
Vol 2 (5-6) ◽  
pp. 361-370 ◽  
Author(s):  
Luigi Benini ◽  
Paolo Rizzotti ◽  
Bruna Vaona ◽  
Carlo Sembenini ◽  
Giorgio Brocco ◽  
...  

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