Effects of propylthiouracil (PTU) administration on the synthesis and secretion of thyroglobulin in the rat thyroid gland: A quantitative immunoelectron microscopic study using immunogold technique

1997 ◽  
Vol 8 (4) ◽  
pp. 315-325 ◽  
Author(s):  
Xue Yi ◽  
Koichi Yamamoto ◽  
Lu Shu ◽  
Ryohei Katoh ◽  
Akira Kawaoi
Keyword(s):  
Thyroid Gland ◽  
Microscopic Study ◽  
Immunogold Technique ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

scholarly journals An Electron Microscopic Study on Follicular Formation and TSH Sensitivity of the Fetal Rat Thyroid Gland in Organ Culture.

1993 ◽  
Vol 55 (1) ◽  
pp. 157-160 ◽  
Author(s):  
Tatsuya TAKIZAWA ◽  
Masako YAMAMOTO ◽  
Kazuyoshi ARISHIMA ◽  
Masahiko KUSANAGI ◽  
Hiroaki SOMIYA ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Organ Culture ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Electron Microscopic ◽  
Fetal Rat ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

scholarly journals Early stages of synthesis of thyroglobulin (Tg), thyroxine (T4), and triiodothyronine (T3) in fetal rat thyroid. An immunoelectron microscopic study.

1987 ◽  
Vol 35 (10) ◽  
pp. 1137-1142 ◽  
Author(s):  
A Kawaoi
Keyword(s):  
Thyroid Gland ◽  
Golgi Apparatus ◽  
Microscopic Study ◽  
Immunoelectron Microscopy ◽  
Extracellular Synthesis ◽  
Early Stages ◽  
Perinuclear Space ◽  
Fetal Rat ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

Immunoelectron microscopy was applied for detection of Tg, T4, and T3 in fetal rat thyroid gland during the early stages of synthesis of these compounds, in order to elucidate the subcellular aspects of onset of their production. Tg was detected in the perinuclear space, rER, and Golgi apparatus as early as the sixteenth day of gestation when no follicles had yet formed. When primitive follicles had formed after the seventeenth day of gestation, both T4 and T3, as well as Tg, appeared on the surface of microvilli and occasionally in their core portions. These findings provide evidence to suggest that follicles are essential to extracellular synthesis of T4 and T3 in fetal rat thyroid gland.

Effects of toxic doses of a novel histamine (H2) antagonist on the rat thyroid gland

1987 ◽  
Vol 25 (10) ◽  
pp. 787-794 ◽  
Author(s):  
C.G. Brown ◽  
R.F. Harland ◽  
I.R. Major ◽  
C.K. Atterwill
Keyword(s):  
Thyroid Gland ◽  
H2 Antagonist ◽  
Histamine H2 Antagonist ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

CORRELATION OF IODIDE TRANSPORT WITH Na+, K+ -ATPase, HCO−3-ATPase AND CARBONIC ANHYDRASE ACTIVITIES IN DIFFERENT FUNCTIONAL STATES OF THE RAT THYROID GLAND

1982 ◽  
Vol 92 (3) ◽  
pp. 371-379 ◽  
Author(s):  
S.-Y. CHOW ◽  
J. W. KEMP ◽  
D. M. WOODBURY
Keyword(s):  
Thyroid Gland ◽  
Carbonic Anhydrase ◽  
Protein Content ◽  
Chronic Treatment ◽  
Cell Water ◽  
Iodide Uptake ◽  
G Cell ◽  
Functional States ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

The effects of thyrotrophin, hypophysectomy, and chronic treatment with thyroxine and methimazole on radioiodide uptake (thyroid/plasma (T/P) 125I− ratio), protein and DNA contents and activities of Na+,K+ -ATPase, HCO−3-ATPase, and carbonic anhydrase (CA) of rat thyroid gland were evaluated. Thyrotrophin given to intact rats slightly increased thyroid iodide uptake, did not affect protein or DNA content, and slightly inhibited CA activity (units/g cell water). Hypophysectomy markedly decreased T/P 125I− ratio, increased protein content, decreased activity of Na+,K+-ATPase, and slightly increased HCO−3-ATPase (nmol/mg DNA per min) and CA (units/g cell water) activities. Thyro-trophin given to hypophysectomized rats (as compared with untreated hypophysectomized control animals) markedly increased T/P 125I− ratio, slightly decreased protein content and decreased Na+,K+-ATPase and CA activities. Chronic treatment with methimazole increased T/P 125I− ratio, decreased protein content, markedly increased Na+,K+-ATPase and HCO−3-ATPase activities, and decreased CA activity. Chronic treatment with thyroxine, in contrast, decreased T/P 125I− ratio, decreased Na+,K+-ATPase activity, and increased CA activity. There was a significant inverse correlation between T/P 125I− ratio and CA activity in follicular cells for the various induced functional states of the thyroid.

scholarly journals The free iodotyrosines of the rat thyroid gland

1963 ◽  
Vol 86 (1) ◽  
pp. 86-92 ◽  
Author(s):  
R PITT-RIVERS ◽  
RR CAVALIERI
Keyword(s):  
Thyroid Gland ◽  
Rat Thyroid ◽  
Rat Thyroid Gland
Sign in / Sign up

Export Citation Format

Share Document