Evidence for a new tumour suppressor gene locus for γ-radiation-induced thymic lymphoma located on the proximal part of mouse chromosome 18

2004 ◽  
Vol 6 (2) ◽  
pp. 90-93 ◽  
Author(s):  
María Matabuena de Yzaguirre ◽  
Javier Santos Hernández ◽  
José Fernández Piqueras
Keyword(s):  
Mouse Chromosome ◽  
Gene Locus ◽  
Proximal Part ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Chromosome 18 ◽  
Γ Radiation ◽  
Thymic Lymphoma ◽  
Radiation Induced

scholarly journals RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

2002 ◽  
Vol 2 ◽  
pp. 1885-1890 ◽  
Author(s):  
Mirna Mourtada-Maarabouni ◽  
Gwyn T. Williams
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Suppressor Activity ◽  
Tumour Suppression ◽  
Major Significance ◽  
Tumour Suppressor Activity ◽  
Alternatively Spliced ◽  
Candidate Tumour Suppressor

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

546 A potential second tumour suppressor gene locus located at chromosome 9p21 in non-small cell lung cancer

Lung Cancer ◽  
1997 ◽  
Vol 18 ◽  
pp. 140
Author(s):  
Leeanne Mead ◽  
Matthew Gillespie ◽  
Kathleen Rayeroux ◽  
Usha Rane ◽  
Lou Irving ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Small Cell ◽  
Tumour Suppressor ◽  
Small Cell Lung ◽  
Chromosome 9P21

scholarly journals Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis ofCYP2D6,SREBP2 andNAGA

2000 ◽  
Vol 87 (6) ◽  
pp. 798-802 ◽  
Author(s):  
Emma J. Bryan ◽  
Nicola A. Thomas ◽  
Karan Palmer ◽  
Elisabeth Dawson ◽  
Patricia Englefield ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mutation Analysis ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Chromosome Arm

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

1996 ◽  
Vol 97 (6) ◽  
pp. 834-837 ◽  
Author(s):  
Huib Caron ◽  
Peter van Sluis ◽  
Roman Buschman ◽  
Ruth Pereira do Tanque ◽  
Patricia Maes ◽  
...  
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Allelic Loss ◽  
Chromosome 4

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

1996 ◽  
Vol 97 (6) ◽  
pp. 834-837 ◽  
Author(s):  
H. Caron ◽  
Peter van Sluis ◽  
Roman Buschman ◽  
Ruth Pereira do Tanque ◽  
Patricia Maes ◽  
...  
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Allelic Loss ◽  
Chromosome 4

scholarly journals The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update

2006 ◽  
Vol 6 ◽  
pp. 1705-1712 ◽  
Author(s):  
Mirna M Maarabouni ◽  
Gwyn T Williams
Keyword(s):  
Gene Locus ◽  
Human Cancer ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Suppressor Activity ◽  
Major Significance ◽  
Tumour Suppressor Activity ◽  
Alternatively Spliced ◽  
Candidate Tumour Suppressor

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

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