scholarly journals Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53 mutation and identifies a tumour suppressor gene locus at 5q13.1-21

1996 ◽  
Vol 74 (1) ◽  
pp. 115-119 ◽  
Author(s):  
M Tavassoli ◽  
H Steingrimsdottir ◽  
E Pierce ◽  
X Jiang ◽  
M Alagoz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Loss Of Heterozygosity ◽  
Gene Locus ◽  
Tp53 Mutation ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Chromosome 5Q

scholarly journals Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis ofCYP2D6,SREBP2 andNAGA

2000 ◽  
Vol 87 (6) ◽  
pp. 798-802 ◽  
Author(s):  
Emma J. Bryan ◽  
Nicola A. Thomas ◽  
Karan Palmer ◽  
Elisabeth Dawson ◽  
Patricia Englefield ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Mutation Analysis ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Chromosome Arm

scholarly journals Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts

2019 ◽  
Vol 2 (4) ◽  
pp. 85 ◽  
Author(s):  
Hölzl-Armstrong ◽  
Kucab ◽  
Korenjak ◽  
Luijten ◽  
Phillips ◽  
...  
Keyword(s):  
Tp53 Mutation ◽  
Human Cancer ◽  
Atmospheric Oxygen ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
International Agency ◽  
Human Tumours ◽  
Clonal Cell Lines ◽  
Gene Tp53

DNA in dividing cells is prone to mutagenesis, with mutations making key contributions to human disease including cancer. The tumour suppressor gene TP53 is the most frequently mutated gene in human tumours. Here, we present a robust protocol for studying TP53 mutagenesis utilising human TP53 knock-in (Hupki) mouse embryonic fibroblasts (HUFs). In the HUF immortalisation assay (HIMA), primary HUFs are treated with known or suspected carcinogens at 3% oxygen and then transferred to 20% atmospheric oxygen to induce senescence. Cells containing mutations (e.g., in TP53) that allow bypassing of senescence eventually emerge as immortalised clonal cell lines after 2–3 months of serial passaging. As not all immortalised HUF cells contain TP53 mutations, we developed a Nutlin-3a counter-screen to select for TP53-mutated clones prior to sequencing. TP53 mutation spectra generated can be compared with those of human tumours recorded in the International Agency for Research on Cancer TP53 mutation database. Environmental mutagens that have demonstrated and validated the utility of the HIMA include ultraviolet radiation, aristolochic acid, and benzo[a]pyrene. The TP53 mutation patterns induced by these mutagens in the HIMA corresponded to those found in human tumours from patients exposed to these mutagens. The approach presented helps to deepen our understanding of human cancer aetiology.

scholarly journals RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

2002 ◽  
Vol 2 ◽  
pp. 1885-1890 ◽  
Author(s):  
Mirna Mourtada-Maarabouni ◽  
Gwyn T. Williams
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Suppressor Activity ◽  
Tumour Suppression ◽  
Major Significance ◽  
Tumour Suppressor Activity ◽  
Alternatively Spliced ◽  
Candidate Tumour Suppressor

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

546 A potential second tumour suppressor gene locus located at chromosome 9p21 in non-small cell lung cancer

Lung Cancer ◽  
1997 ◽  
Vol 18 ◽  
pp. 140
Author(s):  
Leeanne Mead ◽  
Matthew Gillespie ◽  
Kathleen Rayeroux ◽  
Usha Rane ◽  
Lou Irving ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Small Cell ◽  
Tumour Suppressor ◽  
Small Cell Lung ◽  
Chromosome 9P21

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

1996 ◽  
Vol 97 (6) ◽  
pp. 834-837 ◽  
Author(s):  
Huib Caron ◽  
Peter van Sluis ◽  
Roman Buschman ◽  
Ruth Pereira do Tanque ◽  
Patricia Maes ◽  
...  
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Allelic Loss ◽  
Chromosome 4

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis

2010 ◽  
Vol 46 (4) ◽  
pp. 818-825 ◽  
Author(s):  
Adam J.W. Paige ◽  
Manuela Zucknick ◽  
Szymon Janczar ◽  
Jim Paul ◽  
Charles A. Mein ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Polymorphisms ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Cancer Pathology

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

1996 ◽  
Vol 97 (6) ◽  
pp. 834-837 ◽  
Author(s):  
H. Caron ◽  
Peter van Sluis ◽  
Roman Buschman ◽  
Ruth Pereira do Tanque ◽  
Patricia Maes ◽  
...  
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Allelic Loss ◽  
Chromosome 4
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