Subacute dementia as presenting feature of carcinomatous leptomeningeal metastases

2005 ◽  
Vol 7 (1) ◽  
pp. 29-30
Author(s):  
María Sereno Moyano ◽  
Enrique Casado Saenz ◽  
Cristóbal Belda Iniesta ◽  
Manuel González Barón
Keyword(s):  
Leptomeningeal Metastases ◽  
Subacute Dementia

Gd-DTPA-enhanced MR detection of diffuse leptomeningeal metastases

1989 ◽  
Vol 153 (4) ◽  
pp. 888-888
Author(s):  
PA Cooley ◽  
DJ Czarnecki ◽  
Sty
Keyword(s):  
Leptomeningeal Metastases

scholarly journals TAMI-57. MEDULLOBLASTOMA UTILIZE GABA TRANSAMINASE TO SURVIVE IN THE CEREBROSPINAL FLUID MICROENVIRONMENT AND PROMOTE LEPTOMENINGEAL DISSEMINATION

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii225-ii226
Author(s):  
Vahan Martirosian ◽  
Krutika Deshpande ◽  
Hao Zhou ◽  
Keyue Shen ◽  
Vazgen Stepanosyan ◽  
...  
Keyword(s):  
Energy Source ◽  
Cerebrospinal Fluid ◽  
Oxidative Phosphorylation ◽  
Cancer Cells ◽  
Metastatic Cancer ◽  
Leptomeningeal Metastases ◽  
Metabolic Phenotype ◽  
Leptomeningeal Disease ◽  
Neural Cells ◽  
Gaba Transaminase

Abstract Medulloblastoma (MB) is a malignant pediatric brain tumor. Studies have shown heterogeneous cells amongst the tumor bulk which mirror normal neural cells in various neurodevelopmental stages. To discern exploited mechanisms promoting MB leptomeningeal disease, we drew conclusions from developmental neurobiology. In normal differentiation, the metabolic phenotype in proliferating neural progenitor cells evolves from a glycolysis-dependent to an oxidative phosphorylation-reliant energetic profile in quiescent differentiated neurons. Cancer cells mirror this evolution, which also grants them the capability to utilize alternative nutrients in the microenvironment as an energy source. Considering metastatic cells are typically in a dormant state and primarily utilize oxidative phosphorylation, we hypothesized metastatic MB cells emulate a quiescent neuron-like cellular profile to survive in the cerebrospinal fluid and form leptomeningeal metastases. To examine this, we query the expression of GABA catabolic enzyme GABA transaminase (ABAT) in MB. GABA is found in the cerebellar and leptomeningeal microenvironments, and is utilized by metastatic cancer cells in the CNS as an energy source. We correlate an increase in ABAT expression with neurodevelopment and show heterogeneous expression of this protein in primary MB tumors. MB cells with increased expression of ABAT were slower-dividing, expressed a genetic and metabolic phenotype reminiscent of quiescent neuron-like cells, and had increased capability to metabolize GABA. Conversely, lower expression of ABAT was associated with an increased proliferation rate and correlated with a progenitor-like cellular profile. Transplantation of MB cells into the leptomeningeal compartment decreased proliferative capacity and enhanced ABAT expression. Xenograft models showed MB cells with ABAT knockdown had increased growth in the cerebellar microenvironment. Conversely, MB cells with ABAT overexpression transplanted into the cerebrospinal fluid formed leptomeningeal metastases whereas ABAT knockdown cells could not. These results suggest ABAT expression in MB cells can be modulated by the tumor microenvironment and is required to form leptomeningeal metastases.

Merkel cell carcinoma of the skin with leptomeningeal metastases

2005 ◽  
Vol 26 (3) ◽  
pp. 210-213 ◽  
Author(s):  
Daniel T. Chang ◽  
Anthony A. Mancuso ◽  
Charles E. Riggs ◽  
William M. Mendenhall
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Leptomeningeal Metastases ◽  
Merkel Cell

scholarly journals Efficacy of multimodal treatment for leptomeningeal metastases in a lung cancer harboring an EGFR mutation

2016 ◽  
pp. 1753 ◽  
Author(s):  
Toshio Kubo ◽  
Daisuke Morichika ◽  
Hiroko Gotoda ◽  
Tomoki Tamura ◽  
Kadoaki Ohashi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multimodal Treatment ◽  
Egfr Mutation ◽  
Leptomeningeal Metastases

Marantic Endocarditis With Cardioembolic Strokes Mimicking Leptomeningeal Metastases in Breast Cancer

2011 ◽  
Vol 29 (29) ◽  
pp. e743-e746 ◽  
Author(s):  
Nils D. Arvold ◽  
Liangge Hsu ◽  
Wendy Y. Chen ◽  
Laura R. Benzaquen ◽  
Stephanie E. Weiss
Keyword(s):  
Breast Cancer ◽  
Leptomeningeal Metastases ◽  
Marantic Endocarditis

scholarly journals Impact of Multimodality Approach for Patients with Leptomeningeal Metastases from Solid Tumors

2014 ◽  
Vol 29 (8) ◽  
pp. 1094 ◽  
Author(s):  
Jeanny Kwon ◽  
Eui Kyu Chie ◽  
Kyubo Kim ◽  
Hak Jae Kim ◽  
Hong-Gyun Wu ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Leptomeningeal Metastases ◽  
Multimodality Approach

scholarly journals EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

2015 ◽  
Vol 18 (6) ◽  
pp. 855-862 ◽  
Author(s):  
Bojana Milojkovic Kerklaan ◽  
Dick Pluim ◽  
Mijke Bol ◽  
Ingrid Hofland ◽  
Johan Westerga ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Diagnostic Accuracy ◽  
Leptomeningeal Metastases ◽  
Epithelial Tumors

Leptomeningeal Metastases

2008 ◽  
pp. 181-201
Author(s):  
Ayman I. Omar ◽  
Warren P. Mason
Keyword(s):  
Leptomeningeal Metastases

scholarly journals BMET-30. TREATMENT OPTIONS OF LONG TERM SURVIVORS WITH LEPTOMENINGEAL METASTASES AND BREAST CANCER

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi33-vi33 ◽  
Author(s):  
Caroline Chaul-Barbosa ◽  
Aki Morikawa ◽  
Sujata Patil ◽  
Adrienne Boire ◽  
Lilly Jordan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Options ◽  
Leptomeningeal Metastases ◽  
Long Term Survivors
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