Are anti-ribosomal P protein antibodies relevant in systemic lupus erythematosus?

2007 ◽  
Vol 32 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Emese Kiss ◽  
Yehuda Shoenfeld
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
P Protein ◽  
Ribosomal P

scholarly journals Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus

Medicine ◽  
2020 ◽  
Vol 99 (20) ◽  
pp. e20192
Author(s):  
Yanping Wang ◽  
Peng Luo ◽  
Ting Guo ◽  
Lin Zou ◽  
Jing Shi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
P Protein ◽  
Ribosomal P

Efficacy of anti-ribosomal P protein antibody testing for diagnosis of systemic lupus erythematosus

2014 ◽  
Vol 24 (6) ◽  
pp. 939-944 ◽  
Author(s):  
Shunsei Hirohata ◽  
Tsuyoshi Kasama ◽  
Yutaka Kawahito ◽  
Katsuhiko Takabayashi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antibody Testing ◽  
Systemic Lupus ◽  
P Protein ◽  
Ribosomal P

scholarly journals AB0449 CLINICAL CHARACTERISTICS AND RISK FACTORS OF SYSTEMIC SCLEROSIS WITH HEMATOLOGIC SYSTEM DAMAGES

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1252.1-1252
Author(s):  
J. Zheng ◽  
Z. R. Dong ◽  
Y. P. Tang ◽  
Y. Q. Huang ◽  
Q. B. Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Risk Factor ◽  
Lupus Erythematosus ◽  
Laboratory Tests ◽  
Clinical Symptoms ◽  
Systemic Lupus ◽  
Logistics Regression ◽  
P Protein ◽  
Ribosomal P

Background:SSc characterized by varying degrees of fibrosis of the skin and internal organs, clinicians pay more attention to skin and viscera conditions, tend to ignore hematologic system damage. Studies have shown that rheumatic disease such as SLE, RA, pSS often accompanied with hematologic system damages, and hematologic system damages is multiple organ involvement and risk factor of poor prognosis[1-2].Objectives:To investigate the the clinical features, laboratory characteristics and risk factors of Systemic Sclerosis (SSc) patient with hematologic system damages.Methods:The clinical data of 180 patients were collected from January 2010 to April 2020, at the Affiliated Hospital of North Sichuan Medical College. The demographic information, laboratory tests, and clinical symptoms were analyzed retrospectively.Results:Among 180 SSc patients, 70(38.9%) cases were complicated with hematologic system damages. 51(72.9%) cases had anemia, 24 cases (34.3%) had leukopenia, 24 cases (34.3%) had thrombocytopenia, and 22 cases had hematologic system damages associated with more than two cell line involvement. Clinical symptoms: arthritis was significantly higher in the hematologic system damages group than patient without (P<0.05), however, there was no significantly difference in gender, age, disease course, respiratory symptoms, gastrointestinal symptoms, Raynaud’s phenomenon, interstitial lung disease and pulmonary hypertension (all P>0.05). Laboratory tests: ESR and hsCRP were increased in the hematologic system damages group, while the albumin decreased (all P<0.05). The positive rates of resistance to anti-dsDNA antibody and anti-ribosomal P protein antibody was higher in the hematologic system damages group (all P<0.05). Prognosis: During follow-up, leukopenia was more likely to recover, while the thrombocytopenia was more difficult to recover. Logistics regression analysis showed that positive of anti-ribosomal P protein antibody maght be a risk factor for SSc complicated with hematologic system damages [OR = 3.930(P<0.05)] (Table 1).Conclusion:SSc complicated with hematologic system damages is common, and patients with hematologic system damages have more serious clinical symptoms, some of whom have difficulty in recovey. Anti-ribosomal P protein antibody may be a risk factor of SSc hematologic system damages.Table 1.Bivariate logistics regression analysis on risk factors associated with hematologic damages in SSc.FactorBSEWaldOR(95%CI)P valuearthritis0.6540.3473.5431.922(0.973-3.797)0.060ESR-0.0810.4870.0280.922(0.355-2.393)0.868hsCRP-0.0070.4920.0000.993(0.379-2.607)0.989anti-dsDNA0.8680.6731.6642.393(0.637-8.916)0.197anti-Rib-P1.3690.6364.6333.930(1.130-13.666)0.031References:[1]González-Naranjo L A, Betancur O M, Alarcón G S, et al. Features associated with hematologic abnormalities and their impact in patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort[J]. Seminars in Arthritis and Rheumatism, 2016,45(6):675-683.DOI:10.1016/j.semarthrit.2015.11.003.[2]Skare T, Damin R, Hofius R. Prevalence of the American College of Rheumatology hematological classification criteria and associations with serological and clinical variables in 460 systemic lupus erythematosus patients[J]. Revista Brasileira de Hematologia e Hemoterapia, 2015,37(2):115-119.DOI:10.1016/j.bjhh.2015.01.006Disclosure of Interests:None declared.

scholarly journals Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Shangzhu Zhang ◽  
Meng Li ◽  
Li Zhang ◽  
Ziqian Wang ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Survival Rates ◽  
Systemic Lupus ◽  
Vessel Disease ◽  
P Protein ◽  
Positive Rate ◽  
Cranial Mri ◽  
Ribosomal P

Objective. To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series in China. Methods. Data of patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to June 2016. NPSLE patients were compared with 220 non-NPSLE patients. Survival rates were evaluated using the Kaplan-Meier curves, log-rank test, and Cox proportional hazards modeling. Cranial MRI results were also studied. Results. Of the 194 included patients, sixteen subtypes of NPSLE were identified, and the most common manifestations were seizure (36.6%), acute confusional state (25.3%), and cerebral vascular disease (15.5%). Compared with the non-NPSLE group, NPSLE patients were significantly more likely to have typical lupus symptoms, higher Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores ( P = 0.002 ), and positive rate of anti-ribosomal P protein antibodies ( P = 0.008 ). Patients with seizure were more likely to have higher SLEDAI-2K scores and positive anti-β2GP1 than non-NPSLE patients. Sixteen patients died during follow-up. The most common cause of death was infection (37.5%). NPSLE significantly decreased survival rates of SLE patients. Patients with elevated serum creatinine ( P = 0.001 ), hypocomplementemia ( P = 0.031 ), and SLEDAI − 2 K   scores ≥ 15 ( P = 0.014 ) had shorter survival periods. Eighty-two patients underwent detailed cranial MRI analysis; of these, 50 (61.0%) had abnormal results. Small vessel disease was the most common abnormal finding, followed by inflammatory-like lesions and large vessel disease. Conclusions. High disease activity and positive rate of anti-ribosomal P protein antibodies may be risk factors for NPSLE. NPSLE decreases survival rates of SLE patients. Renal insufficiency and high disease activity are predictive of poor prognoses for NPSLE patients.

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