scholarly journals Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes

2005 ◽  
Vol 52 (3) ◽  
pp. 847-855 ◽  
Author(s):  
Tatsuo Nagai ◽  
Yoshiyuki Arinuma ◽  
Tamiko Yanagida ◽  
Kazuhiko Yamamoto ◽  
Shunsei Hirohata
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Proinflammatory Cytokines ◽  
Lupus Erythematosus ◽  
Human Peripheral Blood ◽  
Human Systemic Lupus Erythematosus ◽  
Blood Monocytes ◽  
Systemic Lupus ◽  
Peripheral Blood Monocytes ◽  
P Protein ◽  
Ribosomal P

scholarly journals Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus

Medicine ◽  
2020 ◽  
Vol 99 (20) ◽  
pp. e20192
Author(s):  
Yanping Wang ◽  
Peng Luo ◽  
Ting Guo ◽  
Lin Zou ◽  
Jing Shi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
P Protein ◽  
Ribosomal P

Efficacy of anti-ribosomal P protein antibody testing for diagnosis of systemic lupus erythematosus

2014 ◽  
Vol 24 (6) ◽  
pp. 939-944 ◽  
Author(s):  
Shunsei Hirohata ◽  
Tsuyoshi Kasama ◽  
Yutaka Kawahito ◽  
Katsuhiko Takabayashi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antibody Testing ◽  
Systemic Lupus ◽  
P Protein ◽  
Ribosomal P

scholarly journals Tolerogenic versus Inflammatory Activity of Peripheral Blood Monocytes and Dendritic Cells Subpopulations in Systemic Lupus Erythematosus

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Tiago Carvalheiro ◽  
Ana Rodrigues ◽  
Ana Lopes ◽  
Luís Inês ◽  
Isabel Velada ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Mrna Expression ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Inflammatory Activity ◽  
Inactive Disease ◽  
Blood Monocytes ◽  
Systemic Lupus ◽  
Peripheral Blood Monocytes

Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-αand chemokine mRNA expression, respectively, after cell purification. The study included 18 SLE patients with active disease (ASLE), 25 with inactive disease (ISLE), and 30 healthy controls (HG). In purified plasmacytoid DC (pDC) was observed a lower ICOSL mRNA expression in ASLE and an increase in ISLE; similarly, a lower ICOSL mRNA expression in monocytes of ALSE patients was found. However, a higher ICOSL mRNA expression was observed in ASLE compared to HG in myeloid DCs. Interestingly, clinical parameters seem to be related with ICOSL mRNA expression. Regarding the inflammatory activity it was observed in purified monocytes and CD CD16+DCs an increase of CCL2, CXCL9, and CXCL10 mRNA expression in ASLE compared to HG. In myeloid DC no differences were observed regarding chemokines, and IFN-αmRNA expression. In pDC, a higher IFN-αmRNA expression was observed in ASLE. Deviations in ICOSL, chemokine, and IFN-αmRNA expression in peripheral blood monocytes and dendritic cells subpopulations in SLE appear to be related to disease activity.

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