Phasic production of urinary pyridinium crosslinks in mice: The effect of ovariectomy

2001 ◽  
Vol 68 (2) ◽  
pp. 102-108 ◽  
Author(s):  
R. Blanqué ◽  
C. Cottereaux ◽  
C. R. Gardner
Keyword(s):  
Pyridinium Crosslinks

The effect of age on bone collagen turnover as assessed by pyridinium crosslinks and procollagen I C-terminal peptide

1993 ◽  
Vol 3 (S1) ◽  
pp. 100-101 ◽  
Author(s):  
R. Eastell ◽  
N. F. A. Peel ◽  
R. A. Hannon ◽  
A. Blumsohn ◽  
A. Price ◽  
...  
Keyword(s):  
Bone Collagen ◽  
Collagen Turnover ◽  
Pyridinium Crosslinks ◽  
Effect Of Age

Biological Variation in Urinary Excretion of Pyridinium Crosslinks: Recommendations for the Optimum Specimen

1996 ◽  
Vol 33 (1) ◽  
pp. 36-42 ◽  
Author(s):  
M Panteghini ◽  
F Pagani
Keyword(s):  
Early Morning ◽  
Reference Intervals ◽  
Biological Variation ◽  
Creatinine Ratio ◽  
Pyridinium Crosslinks ◽  
Number Of Patients ◽  
Analytical Imprecision ◽  
Optimum Specimen ◽  
The Difference ◽  
Urine Specimens

We assessed the analytical and biological variation of pyridinium crosslinks in early morning, 2 h fasting, and 24 h urine specimens from 14 healthy adults over a 1 month period. The results were expressed both in terms of pyridinoline concentration and pyridinoline/creatinine ratio. The data obtained were used to select the optimum specimen for clinical purposes. We found that: ( a) early morning specimens are preferred; ( b) results should be expressed as pyridinoline/creatinine ratio; ( c) reference intervals should be stratified according to gender; ( d) the necessary analytical imprecision (CV≤ 9%), derived from biological variation, is not easily achieved by current methods; ( e) the difference between serial results from an individual must be > 50% to be statistically significant; and ( f) assessment of risk for osteoporotic fracture by means of the pyridinium crosslink assay would, in a significant number of patients, require analysis of multiple urine specimens.

Pyridinium crosslinks of collagen as a marker of bone resorption rates in children and adolescents: Normal values and clinical application

Bone ◽  
1996 ◽  
Vol 19 (6) ◽  
pp. 669-677 ◽  
Author(s):  
J. Marowska ◽  
M. Kobylińska ◽  
J. Łukaszkiewicz ◽  
A. Tałajko ◽  
B. Rymkiewicz-Kluczyńska ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Children And Adolescents ◽  
Clinical Application ◽  
Normal Values ◽  
Pyridinium Crosslinks

scholarly journals Standardization of pyridinium crosslinks, pyridinoline and deoxypyridinoline, for use as biochemical markers of collagen degradation

1996 ◽  
Vol 42 (10) ◽  
pp. 1621-1626 ◽  
Author(s):  
S P Robins ◽  
A Duncan ◽  
N Wilson ◽  
B J Evans
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Biochemical Markers ◽  
Sodium Phosphate ◽  
Molar Absorptivity ◽  
Collagen Crosslinks ◽  
Urinary Markers ◽  
Pyridinium Crosslinks ◽  
Wide Clinical Application ◽  
Markers Of Bone Resorption

Abstract The collagen crosslinks, pyridinoline and deoxypyridinoline, have been developed as urinary markers of bone resorption but, despite wide clinical application of the technique, comparatively little attention has been paid to the standardization of these compounds. In this study, pyridinoline and deoxypyridinoline have been purified from bone and converted completely to monochloride trihydrochloride salts. In addition to mass spectrometry and NMR spectroscopy, the purity of the isolated materials was assessed by microelemental analysis including the chloride counterions. These purified compounds were used to establish individual molar absorptivity values as primary standardization criteria for the two crosslinks. For pyridinoline in 0.1 mol/L HCl, epsilon at 295 nm was 5490 L mol(-1) cm(-1); in 50 mmol/L sodium phosphate, pH 7.5, epsilon at 325 nm was 5785. The corresponding values for deoxypyridinoline at acid and neutral pH were 5160 and 5290 L mol(-1) cm(-1). The availability of standardization criteria for the crosslinks will allow more meaningful comparisons of clinical data between different laboratories.

Pyridinium crosslinks in the monitoring of patients with bone metastases from carcinoma of the breast

1997 ◽  
Vol 9 (1) ◽  
pp. 30-34 ◽  
Author(s):  
A.J. Walne ◽  
P.J. Jenkins ◽  
I.T. James ◽  
P.N. Plowman
Keyword(s):  
Bone Metastases ◽  
Carcinoma Of The Breast ◽  
Pyridinium Crosslinks

Diurnal rhythm in urinary excretion of pyridinium crosslinks

1994 ◽  
Vol 40 (6) ◽  
pp. 952-953 ◽  
Author(s):  
F Pagani ◽  
M Panteghini
Keyword(s):  
Urinary Excretion ◽  
Diurnal Rhythm ◽  
Pyridinium Crosslinks

Effects of tiaprofenic acid on urinary pyridinium crosslinks in adjuvant arthritic rats: Comparison with doxycycline

1997 ◽  
Vol 46 (7) ◽  
pp. 246-252 ◽  
Author(s):  
K. U. Weithmann ◽  
V. Schlotte ◽  
V. Jeske ◽  
D. Seiffge ◽  
A. Laber ◽  
...  
Keyword(s):  
Tiaprofenic Acid ◽  
Pyridinium Crosslinks

The stability of pyridinium crosslinks in urine and serum

1995 ◽  
Vol 240 (1) ◽  
pp. 95-97 ◽  
Author(s):  
Amanda J. Walne ◽  
Ian T. James ◽  
David Perrett
Keyword(s):  
Pyridinium Crosslinks ◽  
The Stability ◽  
Urine And Serum
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