Effects of tiaprofenic acid on urinary pyridinium crosslinks in adjuvant arthritic rats: Comparison with doxycycline

1997 ◽  
Vol 46 (7) ◽  
pp. 246-252 ◽  
Author(s):  
K. U. Weithmann ◽  
V. Schlotte ◽  
V. Jeske ◽  
D. Seiffge ◽  
A. Laber ◽  
...  
Keyword(s):  
Tiaprofenic Acid ◽  
Pyridinium Crosslinks

Tiaprofenic acid

1994 ◽  
Vol &NA; (492) ◽  
pp. 12
Author(s):  
&NA;
Keyword(s):  
Tiaprofenic Acid

scholarly journals Thiophene-Based Compounds with Potential Anti-Inflammatory Activity

2021 ◽  
Vol 14 (7) ◽  
pp. 692
Author(s):  
Ryldene Marques Duarte da Cruz ◽  
Francisco Jaime Bezerra Mendonça-Junior ◽  
Natália Barbosa de Mélo ◽  
Luciana Scotti ◽  
Rodrigo Santos Aquino de Araújo ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Structural Characteristics ◽  
Tiaprofenic Acid ◽  
Inflammatory Activity ◽  
Drug Candidates ◽  
Biological Target ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Privileged Structures

Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical treatments, despite their severe side effects and their exclusive action in improving symptoms, without effectively promoting the cure. However, recent advances in the fields of pharmacology, medicinal chemistry, and chemoinformatics have provided valuable information and opportunities for development of new anti-inflammatory drug candidates. For drug design and discovery, thiophene derivatives are privileged structures. Thiophene-based compounds, like the commercial drugs Tinoridine and Tiaprofenic acid, are known for their anti-inflammatory properties. The present review provides an update on the role of thiophene-based derivatives in inflammation. Studies on mechanisms of action, interactions with receptors (especially against cyclooxygenase (COX) and lipoxygenase (LOX)), and structure-activity relationships are also presented and discussed. The results demonstrate the importance of thiophene-based compounds as privileged structures for the design and discovery of novel anti-inflammatory agents. The studies reveal important structural characteristics. The presence of carboxylic acids, esters, amines, and amides, as well as methyl and methoxy groups, has been frequently described, and highlights the importance of these groups for anti-inflammatory activity and biological target recognition, especially for inhibition of COX and LOX enzymes.

The effect of age on bone collagen turnover as assessed by pyridinium crosslinks and procollagen I C-terminal peptide

1993 ◽  
Vol 3 (S1) ◽  
pp. 100-101 ◽  
Author(s):  
R. Eastell ◽  
N. F. A. Peel ◽  
R. A. Hannon ◽  
A. Blumsohn ◽  
A. Price ◽  
...  
Keyword(s):  
Bone Collagen ◽  
Collagen Turnover ◽  
Pyridinium Crosslinks ◽  
Effect Of Age

Biological Variation in Urinary Excretion of Pyridinium Crosslinks: Recommendations for the Optimum Specimen

1996 ◽  
Vol 33 (1) ◽  
pp. 36-42 ◽  
Author(s):  
M Panteghini ◽  
F Pagani
Keyword(s):  
Early Morning ◽  
Reference Intervals ◽  
Biological Variation ◽  
Creatinine Ratio ◽  
Pyridinium Crosslinks ◽  
Number Of Patients ◽  
Analytical Imprecision ◽  
Optimum Specimen ◽  
The Difference ◽  
Urine Specimens

We assessed the analytical and biological variation of pyridinium crosslinks in early morning, 2 h fasting, and 24 h urine specimens from 14 healthy adults over a 1 month period. The results were expressed both in terms of pyridinoline concentration and pyridinoline/creatinine ratio. The data obtained were used to select the optimum specimen for clinical purposes. We found that: ( a) early morning specimens are preferred; ( b) results should be expressed as pyridinoline/creatinine ratio; ( c) reference intervals should be stratified according to gender; ( d) the necessary analytical imprecision (CV≤ 9%), derived from biological variation, is not easily achieved by current methods; ( e) the difference between serial results from an individual must be > 50% to be statistically significant; and ( f) assessment of risk for osteoporotic fracture by means of the pyridinium crosslink assay would, in a significant number of patients, require analysis of multiple urine specimens.

scholarly journals Effect of tiaprofenic acid on abnormal sensation in the throat.

1989 ◽  
Vol 82 (10) ◽  
pp. 1497-1506
Author(s):  
Mikikazu Yamagiwa ◽  
Masahiko Kubo ◽  
Teruhiko Harada ◽  
Hiroyuki Yamada ◽  
Yasuo Sakakura
Keyword(s):  
Tiaprofenic Acid

scholarly journals Tiaprofenic acid and cystitis

BMJ ◽  
1994 ◽  
Vol 309 (6954) ◽  
pp. 552-553 ◽  
Author(s):  
D N Bateman
Keyword(s):  
Tiaprofenic Acid
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