Biochemical studies on vitamin A. X. A nutritional investigation of synthetic vitamin A in margarine

1952 ◽  
Vol 29 (4) ◽  
pp. 151-153 ◽  
Author(s):  
Stanley R. Ames ◽  
Marion I. Ludwig ◽  
William J. Swanson ◽  
Philip L. Harris
Keyword(s):  
Vitamin A ◽  
Synthetic Vitamin ◽  
Biochemical Studies

Biochemical Studies on Vitamin A. IX. Biopotency of Neovitamin A in the Rat

1951 ◽  
Vol 73 (3) ◽  
pp. 1252-1254 ◽  
Author(s):  
Philip L. Harris ◽  
Stanley R. Ames ◽  
John H. Brinkman
Keyword(s):  
Vitamin A ◽  
Biochemical Studies

Multiple Congenital Malformations Associated with Maternal Isotretinoin Therapy

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 428-430
Author(s):  
ELIZABETH DE LA CRUZ ◽  
SHYAN SUN ◽  
KAMTORN VANGVANICHYAKORN ◽  
FRANKIN DESPOSITO
Keyword(s):  
Vitamin A ◽  
Congenital Malformations ◽  
Cardiac Anomaly ◽  
Teratogenic Effects ◽  
Experimental Animals ◽  
Synthetic Vitamin ◽  
Extensive Information ◽  
Few Data ◽  
Vitamin A Derivative ◽  
Isotretinoin Therapy

Isotretinoin (Accutane), an oral synthetic vitamin A derivative, introduced in September 1982 by Roche Laboratories has been widely used in the treatment of recalcitrant cystic acne. Although there is extensive information regarding the teratogenic effects of excessive vitamin A in experimental animals,1 there are few data available on its possible effects in humans. We report a case of a preterm infant with microcephaly, microphthalmia, rudimentary pinnae, cardiac anomaly, and hepatocellular derangement born to a mother on isotretinoin therapy. This constellation of abnormalities mimicks the type of malformations seen in the animal models and is strongly suggestive of the teratogenicity of this drug to the human fetus.

Biochemical Studies on Vitamin A. XV. Biopotencies of Geometric Isomers of Vitamin A Aldehyde in the Rat1

1955 ◽  
Vol 77 (15) ◽  
pp. 4136-4138 ◽  
Author(s):  
Stanley R. Ames ◽  
William J. Swanson ◽  
Philip L. Harris
Keyword(s):  
Vitamin A ◽  
Geometric Isomers ◽  
Biochemical Studies

Crystalline Synthetic Vitamin A and Neovitamin A

Science ◽  
1948 ◽  
Vol 107 (2779) ◽  
pp. 346-346 ◽  
Author(s):  
J. D. CAWLEY ◽  
C. D. ROBESON ◽  
L. WEISLER ◽  
E. M. SHANTZ ◽  
N. D. EMBREE ◽  
...  
Keyword(s):  
Vitamin A ◽  
Synthetic Vitamin
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