Effects of sodium glycocholate and sodium taurocholate on the mixed micelles of bile salts and nonionic surfactant

1993 ◽  
Vol 70 (7) ◽  
pp. 693-697 ◽  
Author(s):  
H. Asano ◽  
C. Izumi ◽  
Y. Sano ◽  
Y. Tabata ◽  
M. Ueno
Keyword(s):  
Nonionic Surfactant ◽  
Bile Salts ◽  
Mixed Micelles ◽  
Sodium Taurocholate ◽  
Sodium Glycocholate

Behaviors of Sodium Taurocholate and Sodium Taurodeoxycholate in Binary Mixed Micelles of Bile Salt and Nonionic Surfactant

Langmuir ◽  
1996 ◽  
Vol 12 (23) ◽  
pp. 5536-5540 ◽  
Author(s):  
K. Suzuki ◽  
T. Hasegawa ◽  
Y. Takamura ◽  
K. Takahashi ◽  
H. Asano ◽  
...  
Keyword(s):  
Bile Salt ◽  
Nonionic Surfactant ◽  
Mixed Micelles ◽  
Sodium Taurocholate ◽  
Sodium Taurodeoxycholate

scholarly journals THE EFFECT OF HEMOLYTIC SUBSTANCES ON WHITE CELL RESPIRATION

1936 ◽  
Vol 20 (2) ◽  
pp. 267-281 ◽  
Author(s):  
Eric Ponder ◽  
John Macleod
Keyword(s):  
Oxygen Consumption ◽  
Sodium Oleate ◽  
Bile Salts ◽  
Sodium Taurocholate ◽  
White Cell ◽  
Red Cells ◽  
O2 Consumption ◽  
Cell Respiration ◽  
Sodium Glycocholate

Substances such as saponin, the bile salts, etc., which produce lysis of red cells also produce cytolysis of white cells from rabbit peritoneal exudates, the arbitrary criterion of their cytolytic effect being their ability to depress the O2 consumption of the leucocytes. The amount of cytolysis increases regularly as the amount of the added lysin is increased, and sufficiently large quantities of saponin, sodium taurocholate, sodium glycocholate, or sodium oleate are capable of virtually abolishing the O2 consumption altogether. At the same time, it can be shown that a lysin such as saponin is used up in combining with the white cells in much the same way as it is used up in combining with red cells, and the reduction in oxygen consumption appears to be roughly proportional to the amount so combined. The action of these lytic substances on white cells, in fact, is very similar to their action on red cells, due allowance being made for the fact that the cytolysis of the white cell is probably not an all-or-none process like hemolysis. White cell respiration is also depressed in hypotonic solutions, the respiration being virtually linear with the tonicity.

scholarly journals The kinetics of hæmolysis in cell-Taurocholate-serum systems

1935 ◽  
Vol 117 (804) ◽  
pp. 272-288 ◽  
Keyword(s):  
Silicic Acid ◽  
Plasma Proteins ◽  
Bile Salts ◽  
Brilliant Green ◽  
Sodium Taurocholate ◽  
Alkali Content ◽  
Sodium Glycocholate ◽  
Per Se ◽  
Kinetics Of ◽  
Sufficient Concentration

It is well known that the serum and plasma proteins usually produce inhibition of hæmolysis by saponin, the bile salts, the soaps, and other related lysins. As early as 1908, however, Sachs described an acceleration of hæmolysis as occurring when serum or plasma is added to systems containing sodium oleate, after the oleate had been in contact with the cells for some time. The same effect was later observed, under certain conditions, by Ponder for sodium glycocholate (1922), for sodium taurocholate (1923), and for stearates and oleates (1924), and also by Sen and Mitra (1928) in systems containing taurocholate, although Sen and Sen (1928) had previously failed to obtain it. It is known from these investigations that the concentration of taurocholate, etc., used, the quantity of serum or plasma added, and the time for which the lysin is allowed to react with the cells determine whether, and how great, an acceleration replaces the more usual inhibition, but otherwise the kinetics of hæmolysis in these systems is obscure. They are of interest, however, because of their resemblance to colloidal silicic acid-complement and brilliant green-serum systems, in which the cells react with the lysin only after being acted on by a sensitizing agent, and in which, as in these systems, the order of addition of the various components largely determines the final result (see Ponder, 1928, 1932, a , 1933). It has been already suggested, indeed, that the taurocholate acts by sensitizing the cells to the lytic action of the subsequently added serum, as well as by producing lysis itself, just as brilliant green brings about a similar sensitization, and is, in sufficient concentration, a lysin per se (Ponder, 1934, a ). The only other suggestion which has been put forward is that of Sen and Roy (1930-31), who observe that either an inhibition or an acceleration can be obtained by adding various amines to systems containing sodium taurocholate, the result depending on whether the addition is made before or after the taurocholate has come into contact with the cells. Since the addition of the amines makes the systems containing cells and taurocholate more alkaline (the p H of such systems usually being between 5·0 and 6·0), Sen and Roy suggest that the similar accelerating effect of serum may be due, in part at least, to its alkali content.

Effect of intestinal resection on bile salt absorption in dogs

1965 ◽  
Vol 208 (2) ◽  
pp. 363-369 ◽  
Author(s):  
M. R. Playoust ◽  
Leon Lack ◽  
I. M. Weiner
Keyword(s):  
Bile Salt ◽  
Bile Salts ◽  
Enterohepatic Circulation ◽  
Sodium Taurocholate ◽  
Intestinal Resection ◽  
High Fat ◽  
Salt Absorption ◽  
Complete Failure ◽  
Fat Meal

The efficiency of intestinal absorption of bile salts was evaluated by studying the rate of disappearance of radioactivity from the bile of dogs after the intravenous administration of sodium taurocholate-24-C14. Bile was sampled through an indwelling tube in the gall bladder. One day after a high-fat meal normal dogs retained 48% of the radioactivity; dogs with resection of the jejunum retained 48%, whereas those with resection of the ileum retained only 3% in the bile. This is consistent with previous observations that the ileum is the site of bile salt absorption in vitro and in anesthetized animals. Animals with resection of the ileum exhibited significant steatorrhea; however, three-fourths of the ingested fat was absorbed in spite of almost complete failure to absorb bile salts. This indicates that fat and bile salts are not normally absorbed together. Elimination of enterohepatic circulation of bile salts by resection of the ileum contributes to the observed steatorrhea.

Effect of glycodihydrofuisidate on sulfobromophthalein transport maximum in the hamster

1976 ◽  
Vol 231 (6) ◽  
pp. 1875-1878 ◽  
Author(s):  
Y Delage ◽  
M Dumont ◽  
S Erlinger
Keyword(s):  
Bile Salt ◽  
Transport System ◽  
Bile Salts ◽  
Sodium Taurocholate ◽  
Specific Effect ◽  
Biliary Secretion ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Dye Transport ◽  
Cholesterol Secretion

The effect on sulfobromophathalein transport maximum (Tm) and biliary lipid secretion of sodium glyco-24,25-dihydrofusicate, a micelle-forming compound secreted into bile, has been studied in the hamster and compared to that of a physiological bile salt, sodium taurocholate. Biliary phospholipid and cholesterol secretion increased both during glycodihydrofusidate and taurocholate administration, an observation which suggest that both compounds increased th biliary secretion of micelle-forming compounds. In contrast, only taurocholate increased sulfobromophthalein Tm into bile, while glycodihydrofusidate administration decreased it. This observation suggests that the increase in sulfobromophthalein Tm observed during taurocholate administration is not the result of micellar sequestration. It could rather be the consequence of a specific effect of bile salts on the dye transport system.

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