Reconstitution of the malignant phenotype of genitourinary cancer in gradient culture

1989 ◽  
Vol 25 (5) ◽  
pp. 466-470 ◽  
Author(s):  
Joseph Leighton
Keyword(s):  
Malignant Phenotype ◽  
Genitourinary Cancer ◽  
Gradient Culture

Transcriptome analysis of pediatric cALL versus normal tissue reveals a novel signature of the malignant phenotype

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
GHS Richter ◽  
UE Hattenhorst ◽  
B Beinvogl ◽  
D Schenk ◽  
MS Staege ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Normal Tissue ◽  
Malignant Phenotype

scholarly journals Regulation of Rho GTPases by RhoGDIs in Human Cancers

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1037 ◽  
Author(s):  
Cho ◽  
Kim ◽  
Baek ◽  
Kim ◽  
Lee
Keyword(s):  
Cell Migration ◽  
Cancer Progression ◽  
Anticancer Agents ◽  
Rho Gtpases ◽  
Rho Gtpase ◽  
Regulatory Mechanisms ◽  
Malignant Phenotype ◽  
Cellular Processes ◽  
Human Cancers

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The expression of RhoGDIs has changed in many human cancers and become associated with the malignant phenotype, including migration, invasion, metastasis, and resistance to anticancer agents. Here, we review how RhoGDIs control the function of Rho GTPases by regulating their spatiotemporal activity and describe the regulatory mechanisms of the dissociation of Rho GTPases from RhoGDIs. We also discuss the role of RhoGDIs in cancer progression and their potential uses for therapeutic intervention.

scholarly journals The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.

1994 ◽  
Vol 269 (48) ◽  
pp. 30105-30108
Author(s):  
M Fridman ◽  
A Tikoo ◽  
M Varga ◽  
A Murphy ◽  
M.S. Nur-E-Kamal ◽  
...  
Keyword(s):  
Malignant Phenotype

scholarly journals Brahma‐Related Gene‐1 (BRG1) promotes the malignant phenotype of glioblastoma cells

2021 ◽  
Author(s):  
Yinan Wang ◽  
Chuan He Yang ◽  
Andrew P. Schultz ◽  
Michelle M. Sims ◽  
Duane D. Miller ◽  
...  
Keyword(s):  
Related Gene ◽  
Glioblastoma Cells ◽  
Malignant Phenotype
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