Serum spermidine oxidase activity in patients with insulin-dependent diabetes mellitus and microvascular complications

1990 ◽  
Vol 27 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Giuseppe Seghieri ◽  
Alfredo Gironi ◽  
Margherita Niccolai ◽  
Piero Mammini ◽  
Lorenzo Alviggi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oxidase Activity ◽  
Microvascular Complications ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Spermidine Oxidase

Plasma Semicarbazide-Sensitive Amine Oxidase Activity is Elevated in Diabetes Mellitus and Correlates with Glycosylated Haemoglobin

1995 ◽  
Vol 88 (6) ◽  
pp. 675-679 ◽  
Author(s):  
Frans Boomsma ◽  
Frans H. M. Derkx ◽  
Anton H. van den Meiracker ◽  
Arie J. man in't Veld ◽  
Maarten A. D. H. Schalekamp
Keyword(s):  
Diabetes Mellitus ◽  
Oxidase Activity ◽  
Amine Oxidase ◽  
Microvascular Complications ◽  
Insulin Dependent Diabetes Mellitus ◽  
Glycosylated Haemoglobin ◽  
Dependent Diabetes Mellitus ◽  
Mammalian Tissues ◽  
Insulin Dependent ◽  
Amine Oxidase Activity

1. Semicarbazide-sensitive amine oxidase is a common name for a group of heterogeneous amine oxidases which are present in various mammalian tissues, especially in vascular smooth muscle cells, cartilage and adipose tissue, but also in plasma. 2. Plasma semicarbazide-sensitive amine oxidase activity was elevated in a group of 104 patients with insulin-dependent diabetes mellitus compared with normal control subjects (555 ± 172 versus 352 ± 102 m-units/l, P < 0.0005). 3. Plasma semicarbazide-sensitive amine oxidase activity was higher in subgroups with either retinopathy or nephropathy or both [583 ± 116 (n = 34), 581 ± 229 (n = 10) and. 646 ± 249 m-units/l (n = 19), respectively] than in the subgroup without overt complications [486 ± 129 m-units/l (n = 41), P < 0.005]. 4. Plasma semicarbazide-sensitive amine oxidase activity was positively correlated with plasma glycosylated haemoglobin (r = 0.40; P < 0.0001) and with log urinary albumin excretion (r = 0.26; P < 0.025). 5. The possibility that semicarbazide-sensitive amine oxidase, by its conversion of endogenous amines like methylamine and aminoacetone into cytotoxic aldehydes, plays a role in the development of microvascular complications in diabetes mellitus, needs further investigation.

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