Afferent and efferent nerve endings of the outer hair cells in the rahbit

1980 ◽  
Vol 229 (3-4) ◽  
pp. 175-182 ◽  
Author(s):  
T. Omata ◽  
W. Schätzle
Keyword(s):  
Hair Cells ◽  
Outer Hair Cells ◽  
Nerve Endings ◽  
Efferent Nerve ◽  
Efferent Nerve Endings

scholarly journals DEGENERATION IN THE EFFERENT NERVE ENDINGS IN THE COCHLEA AFTER AXONAL SECTION

1965 ◽  
Vol 26 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Catherine A. Smith ◽  
Grant L. Rasmussen
Keyword(s):  
Plasma Membrane ◽  
Hair Cells ◽  
Cochlear Nerve ◽  
Mitochondrial Swelling ◽  
Nerve Bundle ◽  
Efferent Nerve ◽  
Rapid Process ◽  
Constant Size ◽  
Efferent Nerve Endings ◽  
The Brain

Both roots of the olivo-cochlear nerve bundle to one ear were transected in the brain stems of 12 chinchillas. The animals were sacrificed at times ranging from 2 to 35 days after surgery. The normal olivo-cochlear terminals on the external hair cells in the cochleas of the control ears contained many mitochondria and small vesicles of constant size. The earliest evidence for degeneration was the presence of fine 100 A filaments in the proximal parts of the terminals. These were visible at 2 days. Animals sacrificed at later times showed a greater number of filaments and fewer vesicles, but few mitochondrial changes. After 1 week, disintegration of the terminals was more prominent. A few terminals showed mitochondrial swelling and lysis of the plasma membrane but few or no filaments within the first week. These latter terminals were interpreted as representing a more rapid process of disintegration than those terminals characterized by numerous filaments and seemingly unchanged mitochondria.

scholarly journals NTPDase1 and NTPDase2 Immunolocalization in Mouse Cochlea: Implications for Regulation of P2 Receptor Signaling

2002 ◽  
Vol 50 (11) ◽  
pp. 1435-1441 ◽  
Author(s):  
Srdjan M. Vlajkovic ◽  
Peter R. Thorne ◽  
Jean Sévigny ◽  
Simon C. Robson ◽  
Gary D. Housley
Keyword(s):  
Hair Cells ◽  
Spiral Ganglion ◽  
Organ Of Corti ◽  
Nerve Fibers ◽  
Outer Hair Cells ◽  
Spiral Ligament ◽  
Receptor Signaling ◽  
P2 Receptor ◽  
Efferent Nerve ◽  
Root Region

Cellular, molecular, and physiological studies have demonstrated an important signaling role for ATP and related nucleotides acting via P2 receptors in the cochlea of the inner ear. Signal modulation is facilitated by ectonucleotidases, a heterologous family of surface-located enzymes involved in extracellular nucleotide hydrolysis. Our previous studies have implicated CD39/NTPDase1 and CD39L1/NTPDase2, members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family, as major ATP-hydrolyzing enzymes in the tissues lining the cochlear endolymphatic and perilymphatic compartments. NTPDase1 hydrolyzes both nucleoside triphosphates and diphosphates. In contrast, NTPDase2 is a preferential nucleoside triphosphatase. This study characterizes expression of these E-NTPDases in the mouse cochlea by immunohistochemistry. NTPDase1 can be immunolocalized to the cochlear vasculature and neural tissues (primary auditory neurons in the spiral ganglion). In contrast, NTPDase2 immunolabeling was principally localized to synaptic regions of the sensory inner and outer hair cells, stereocilia and cuticular plates of the outer hair cells, supporting cells of the organ of Corti (Deiters’ cells and inner border cells), efferent nerve fibers located in the intraganglionic spiral bundle, and in the outer sulcus and root region of the spiral ligament. This differential expression of NTPDase1 and 2 in the cochlea suggests spatial regulation of P2 receptor signaling, potentially involving different nucleotide species and hydrolysis kinetics.

Presence of synapsin I in afferent and efferent nerve endings of vestibular sensory epithelia

1986 ◽  
Vol 384 (2) ◽  
pp. 379-382 ◽  
Author(s):  
D. Favre ◽  
E. Scarfone ◽  
G. Di Gioia ◽  
P. De Camilli ◽  
D. Dememes
Keyword(s):  
Nerve Endings ◽  
Synapsin I ◽  
Efferent Nerve ◽  
Sensory Epithelia ◽  
Vestibular Sensory Epithelia ◽  
Efferent Nerve Endings

A Study of the Nerve Endings of the Outer Hair Cells in the Organ of Corti

1985 ◽  
Vol 12 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Yasuo Harada ◽  
Dominggus Mangape ◽  
Nobuharu Tagashira
Keyword(s):  
Hair Cells ◽  
Organ Of Corti ◽  
Outer Hair Cells ◽  
Nerve Endings

Principles in embryonic development and differentiation of vestibular hair cells

1983 ◽  
Vol 91 (5) ◽  
pp. 540-549 ◽  
Author(s):  
Matti Anniko ◽  
Hans Nordemar ◽  
Aron Sobin
Keyword(s):  
Gap Junctions ◽  
Hair Cell ◽  
Hair Cells ◽  
Ultrastructural Level ◽  
Efferent Nerve ◽  
Vestibular Hair Cells ◽  
Transmission Electron ◽  
Sensory Hairs ◽  
Development And Differentiation ◽  
Efferent Nerve Endings

The early development and maturation of vestibular hair cells in the CBA/CBA mouse were analyzed at the ultrastructural level with conventional transmission electron microscopy and freeze fracturing. Cells differentiating into future hair cells pass their terminal mitosis close to the otocyst lumen. The earliest morphologic sign of differentiation into future hair cells was the arrangement of microvilli in a regular fashion. Hair cell cytodifferentiation occurred with a gradient from the hair cell surface to the base. In parallel with the maturation of sensory hairs a structural intracellular rebuilding occurred: the number of polyribosomes and amount of rough endoplasmic reticulum decreased, the nucleus moved basally, and mitochondria accumulated in the supranuclear region. Both tight junctions and gap junctions occurred initially on developing hair cells. From the sixteenth gestational day on, gap junctions disappeared, indicating an uncoupling phenomenon. Afferent nerve terminals developed before efferent nerve endings. Maturation of innervation occurred, for the most part, postnatally, and after that hair cells reached mature morphology.

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