Gastrointestinal effect of calcitonin: Inhibition of gastrin secretion

1975 ◽  
Vol 21 (1) ◽  
pp. 299-303
Author(s):  
I. Hornum ◽  
J. Fahrenkrug ◽  
J. F. Rehfeld
Keyword(s):  
Gastrointestinal Effect ◽  
Gastrin Secretion

Inhibition of Meal-Stimulated Gastrin Secretion after Oral Glucose

1976 ◽  
Vol 36 (4) ◽  
pp. 379-381 ◽  
Author(s):  
O. Brandsborg ◽  
M. Brandsborg ◽  
N. A. Lövgreen ◽  
N. J. Christensen
Keyword(s):  
Oral Glucose ◽  
Gastrin Secretion

scholarly journals Gastrin and the Moderate Hypergastrinemias

2021 ◽  
Vol 22 (13) ◽  
pp. 6977
Author(s):  
Jens F. Rehfeld
Keyword(s):  
Helicobacter Pylori ◽  
Plasma Concentrations ◽  
Antral Mucosa ◽  
Serum Concentrations ◽  
Health Issues ◽  
Gastrin Secretion ◽  
Mucosal Growth ◽  
Early Phases ◽  
Molecular Nature ◽  
Concentration Levels

The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first premise the normal biogenesis of gastrin in the antral mucosa, but also mentions the extraantral expression. Subsequently, the molecular nature and concentration levels of gastrin in serum or plasma are overviewed. Third, assays for accurate measurements of plasma or serum concentrations are commented. Finally, the problem of moderate hypergastrinemia due to Helicobacter pylori infections and/or treatment with proton-pump inhibitors (PPI) is discussed. The review concludes that accurate measurement of the true concentrations of bioactive gastrins in plasma is important. Moreover, it suggests that moderate hypergastrinemias are also essential health issues that require serious attention.

Differential stimulation of pancreatic-polypeptide and gastrin secretion by bombesin in man

Life Sciences ◽  
1981 ◽  
Vol 28 (23) ◽  
pp. 2617-2621 ◽  
Author(s):  
Laura de Magistris ◽  
Gianfranco Delle Fave ◽  
Anna Kohn ◽  
Thue W. Schwartz
Keyword(s):  
Pancreatic Polypeptide ◽  
Gastrin Secretion ◽  
Stimulation Of

Depressed gastrin secretion in burns

Burns ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 19-20 ◽  
Author(s):  
J. Steen ◽  
O. Muchardt ◽  
B. Sørensen ◽  
F. Stadil
Keyword(s):  
Gastrin Secretion

Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP

1999 ◽  
Vol 276 (1) ◽  
pp. G21-G27 ◽  
Author(s):  
Yana Zavros ◽  
William R. Fleming ◽  
Arthur Shulkes
Keyword(s):  
Normal Animal ◽  
Differential Regulation ◽  
Local Source ◽  
Major Influence ◽  
Plasma Gastrin ◽  
Gastrin Releasing Peptide ◽  
Gastrin Secretion ◽  
Stimulation Of

Gastrin-releasing peptide (GRP) can stimulate both gastrin and somatostatin (SOM) secretion, but, as gastrin increases SOM and SOM in turn inhibits gastrin, the overall endpoint in terms of gastrin output is variable. To examine the mechanisms involved, we compared the effects of GRP on gastrin secretion in normal sheep and sheep chronically immunized against SOM. In the normal animal, GRP had no effect on either plasma gastrin or SOM. However, in sheep immunized against SOM, GRP stimulated gastrin secretion, suggesting that the concurrent stimulation of SOM prevents the increase in gastrin secretion. To determine the local source of SOM, GRP was then infused into nonimmunized sheep with cannulas draining blood from the fundus and antrum. GRP stimulated fundic SOM output but inhibited antral SOM and gastrin secretion, demonstrating that the fundus was the source of the SOM. Because cholinergic interactions have a major influence on the effects of GRP, a cholinergic stimulus was administered, and we found that the responses were different: SOM output was inhibited in both the antrum and fundus, and antral gastrin secretion was increased. The present study demonstrates two further instances of the differential regulation of SOM from the antrum and fundus. GRP fails to stimulate gastrin because of an increase in fundic SOM, whereas gastrin levels increase following a cholinergic stimulus because of inhibition of both antral and fundic SOM secretion.

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