The effect of a salmon diet on blood clotting, platelet aggregation and fatty acids in normal adult men

Lipids ◽  
1991 ◽  
Vol 26 (2) ◽  
pp. 87-96 ◽  
Author(s):  
Gary J. Nelson ◽  
Perla C. Schmidt ◽  
Laurence Corash
Keyword(s):  
Fatty Acids ◽  
Platelet Aggregation ◽  
Blood Clotting ◽  
Normal Adult ◽  
Adult Men ◽  
Salmon Diet

scholarly journals The effect of triacylglycerol fatty acid positional distribution on postprandial plasma metabolite and hormone responses in normal adult men

1994 ◽  
Vol 71 (3) ◽  
pp. 401-410 ◽  
Author(s):  
A. Zampelas ◽  
Christine M. Williams ◽  
Linda M. Morgan ◽  
J. Wright ◽  
P. T. Quinlan
Keyword(s):  
Fatty Acids ◽  
Adult Male ◽  
Saturated Fatty Acids ◽  
Positional Distribution ◽  
Gastric Inhibitory Polypeptide ◽  
Normal Adult ◽  
Postprandial Lipaemia ◽  
Liquid Meal ◽  
Adult Men ◽  
Male Subjects

The present study has examined the possibility that the positional distribution of fatty acids on dietary triacylglycerol (TAG) influences the postprandial response to a liquid meal in adult subjects. Postprandial TAG, non-esterified fatty acids (NEFA), ketones, glucose, insulin and gastric inhibitory polypeptide (GIP) responses were monitored in sixteen normal adult male subjects over 6 h following consumption of test meals containing dietary TAG in which palmitic acid was predominantly on the sn-1 (Control) or sn-2 positions (Betapol). Plasma total TAG, chylomicron-rich TAG and chylomicron-poor TAG concentrations were identical in response to the two test meals. The peak increase (mean (sd)) in chylomicron TAG was 0 85 (0 46) mmol/l after the Control meal and 0 85 (0 42) mmol/l after the Betapol meal. Plasma glucose, insulin, GIP, NEFA and ketone concentrations were also very similar following the two meals. It is concluded that dietary TAG containing saturated fatty acids on the sn-2 position appear in plasma at a similar level and over a similar timescale to TAG in which saturated fatty acids are predominantly located on sn-1 or sn-3 positions. The results reported in the present study demonstrate that the positional distribution of fatty acids on dietary TAG is not an important determinant of postprandial lipaemia in adult male subjects, but do not exclude the possibility that different responses may occur when these dietary TAG are given long term.

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

The effects of sprint interval exercise on blood cytokine, CRP, and lipid in over-weight and normal adult men

2017 ◽  
Vol 26 (1) ◽  
pp. 885-893
Author(s):  
Ji-Young Ahn ◽  
Jin-Seok Lee ◽  
Chang-Gyun Kim ◽  
Sung-Jin Yoon
Keyword(s):  
Normal Adult ◽  
Interval Exercise ◽  
Adult Men

scholarly journals Anti-Platelet Properties of Apple Must/Skin Yeasts and of Their Fermented Apple Cider Products

Beverages ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 54
Author(s):  
Donal Moran ◽  
Mary Fleming ◽  
Eimear Daly ◽  
Natasha Gaughan ◽  
Ioannis Zabetakis ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Platelet Aggregation ◽  
Functional Properties ◽  
Human Platelet ◽  
Omega 3 ◽  
Apple Cider ◽  
Human Platelet Aggregation ◽  
Yeast Strains ◽  
Omega 6 ◽  
Anti Inflammatory

Alcoholic beverages like apple cider are considered functional beverages with several health benefits, when consumed in moderation, which are mainly attributed to their microbiota and the plethora of their bioactive compounds. Among them, bio-functional polar lipids (PL) have recently been found in apple cider, which despite low quantities, have exhibited strong anti-inflammatory and anti-platelet properties, while fermentation seems to affect the functionality of apple cider’s PL bioactives. The aim of the present study was to elaborate yeast strains isolated from the complex mixtures of apple surface and must yeasts for evaluating their effects on the anti-platelet functional properties of PL bioactives from their final fermented apple cider products. First, bio-functional PL were extracted and separated from the biomass of the different isolated apple surface/must yeast strains, and were further assessed for their anti-platelet potency against human platelet aggregation induced by the potent inflammatory and thrombotic mediator platelet-activating factor (PAF), or by a classic platelet agonist like adenosine diphopshate (ADP). Novel functional apple ciders were then produced from the fermentation of apple juice by elaborating the most bioactive and resilient yeast strains isolated from the apple must with optimum fermentation properties. PL bioactives extracted from these novel apple cider products were also further assessed for their anti-platelet properties against both the PAF and ADP pathways of human platelet aggregation. These novel cider products were found to contain PL bioactives with lower IC50 values (~40 μg) and thus increased anti-platelet potency against platelet aggregation induced by PAF and ADP. GC-MS analysis of the PL bioactives extracted from these novel apple ciders showed that apple cider PL bioactives are rich in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), such as the omega-6 linoleic acid (LA) and the omega-3 alpha linolenic acid (ALA), with favorably lower levels for their omega-6/omega-3 PUFA ratio, which further support the observed strong anti-platelet properties putative anti-inflammatory potency for the apple cider PL bioactives. However, further studies are needed in order to elucidate and fully characterize the apple yeast strains that can be utilized for increasing the anti-inflammatory, anti-platelet and cardioprotective functional properties of their fermented apple cider products.

Inhibitory potencies of fish oil hydroxy fatty acids on cellular lipoxygenases and platelet aggregation

1991 ◽  
Vol 42 (4) ◽  
pp. 959-962 ◽  
Author(s):  
Jack Y. Vanderhoek ◽  
Norberta W. Schoene ◽  
Pham Phi-Phung T.
Keyword(s):  
Fatty Acids ◽  
Platelet Aggregation ◽  
Fish Oil ◽  
Hydroxy Fatty Acids

Personalized approach to procurement of hemocomponents taking into account hemostasis characteristics of donors

2018 ◽  
Author(s):  
А.Ф. Кубиддинов ◽  
Д.С. Саидов ◽  
М.З. Тагожонов ◽  
А.А. Одинаев ◽  
З.Ф. Тагожонов ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Factor Viii ◽  
Blood Clotting ◽  
International Normalized Ratio ◽  
Blood Components ◽  
Transfusion Therapy ◽  
At Iii ◽  
Personalized Approach ◽  
Von Willebrand ◽  
Fibrinogen Content

Цель исследования: изучение параметров гемостаза у доноров для оптимизации использования компонентов крови у пациентов с нарушениями свертывания крови. Материалы и методы. Проанализированы результаты коагулологического исследования крови у 200 доноров. Контрольную группу составили 50 человек — здоровые люди (добровольцы), не доноры в возрасте от 20 до 60 лет. Измеряли: время свертывание крови по Ли-Уайту, активированное частичное тромбопластиновое время, международное нормализованное отношение, агрегацию тромбоцитов, антитромбин III (АТ-III), содержание фибриногена по Клаусу, фактор фон Виллебранда (ФВ), активность фактора VIII. Рассчитывали среднюю арифметическую и среднюю ошибку средней арифметической (М ± m), для оценки значимости различий средних величин использовали t-критерий Стьюдента, различия считали статистически значимыми при р < 0,05. Результаты. Оценка показателей гемостаза показала как развитие у доноров склонности к гиперкоагуляции, так и компенсаторную активацию антикоагулянтной системы. В зависимости от возраста и количества кровосдач агрегация тромбоцитов, АТ-III, содержание фибриногена, активность ФВ и фактора VIII в заготовленных компонентах крови получаются различными. Заключение. Трансфузионная терапия коагулопатий может быть оптимизирована за счет применения компонентов крови, целенаправленно заготовленных с учетом характера нарушений свертывания крови у реципиента. Aim: to optimize the usage of blood components in patients with coagulopathy we analyze some hemostasis parameters in donors. Materials and methods. In 200 donors and 50 healthy volunteers (aged from 20 to 60 years old) we analyzed hemostatic parameters: whole blood clotting time, activated partial thromboplastin time, international normalized ratio, platelet aggregation, antithrombin III (AT-III), Claus fibrinogen content, activity of von Willebrand factor (VWF) and factor VIII. The results obtained presented as M ± m. Statistical diff erences by Student test were considered as signifi cant for p < 0,05. Results. All donors had the tendency to hypercoagulation with compensatory activation of anticoagulant system. Depending on the age and number of blood donations, obtained blood components were diff erent in platelet aggregation, AT-III level, fibrinogen content, activity of VWF and factor VIII. Conclusion. Transfusion therapy of coagulopathies can be optimized through the use of blood components purposefully prepared taking into account the nature of blood clotting disorders in the recipient.

scholarly journals Dose-response effects of omega-3 on platelet aggregation: an observational study

2018 ◽  
Vol 46 (12) ◽  
pp. 5074-5082 ◽  
Author(s):  
Thomas Kander ◽  
Erik Lindblom ◽  
Ulf Schött
Keyword(s):  
Fatty Acids ◽  
Platelet Aggregation ◽  
Healthy Volunteers ◽  
Dose Response ◽  
High Dose ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Positive Health ◽  
Inhibiting Effect

Objective This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers. Methods Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids. Results There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA . Conclusions Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA.

Effects of high- and low-fat diets on the bioavailability of selected fatty acids, including linoleic acid, in adult men

1986 ◽  
Vol 6 (8) ◽  
pp. 931-955 ◽  
Author(s):  
Olukemi Olubajo ◽  
Mary W. Marshall ◽  
Joseph T. Judd ◽  
James T. Adkins
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Low Fat ◽  
Adult Men ◽  
Fat Diets
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