Effects of dietary proteins on linoleic acid desaturation and membrane fluidity in rat liver microsomes

Lipids ◽  
1993 ◽  
Vol 28 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Kazunori Koba ◽  
Kosaburo Wakamatsu ◽  
Keisuke Obata ◽  
Michihiro Sugano
Keyword(s):  
Linoleic Acid ◽  
Membrane Fluidity ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Dietary Proteins ◽  
Rat Liver Microsomes

scholarly journals Alteration in Membrane Fluidity of Rat Liver Microsomes and of Liposomes by Protoporphyrin and Its Anti-lipidperoxidative Effect.

2000 ◽  
Vol 23 (4) ◽  
pp. 415-419 ◽  
Author(s):  
Kimie IMAI ◽  
Tachio AIMOTO ◽  
Toshihide SHIMA ◽  
Toshiaki NAKASHIMA ◽  
Masaki SATO ◽  
...  
Keyword(s):  
Membrane Fluidity ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes

scholarly journals Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats

1987 ◽  
Vol 245 (3) ◽  
pp. 907-910 ◽  
Author(s):  
M W Hamm ◽  
V Chan ◽  
G Wolf
Keyword(s):  
Fatty Acids ◽  
Vitamin A ◽  
Membrane Fluidity ◽  
Rat Liver ◽  
Microsomal Fraction ◽  
Liver Microsomes ◽  
Membrane Lipid ◽  
Microsomal Membrane ◽  
Rat Liver Microsomes ◽  
Omega 6

Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids.

scholarly journals The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450

1969 ◽  
Vol 115 (3) ◽  
pp. 547-554 ◽  
Author(s):  
Richard P. Di Augustine ◽  
James R. Fouts
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Rat Liver ◽  
Unsaturated Fatty Acids ◽  
Liver Microsomes ◽  
Type I ◽  
Rat Liver Microsomes ◽  
Microsomal Metabolism ◽  
Nitrobenzoic Acid

1. The effects of unsaturated fatty acids on drug-metabolizing enzymes in vitro were measured by using rat and rabbit hepatic 9000g supernatant fractions. 2. Unsaturated fatty acids inhibited the hepatic microsomal metabolism of ‘type I’ drugs with inhibition increasing with unsaturation: arachidonic acid>linolenic acid>linoleic acid>oleic acid. Inhibition was independent of lipid peroxidation. Linoleic acid competitively inhibited the microsomal O-demethylation of p-nitroanisole and the N-demethylation of (+)-benzphetamine. 3. The hepatic microsomal metabolism of ‘type II’ substrates, aniline and (−)-amphetamine, was not affected by unsaturated fatty acids. 4. The rate of reduction of p-nitrobenzoic acid and Neoprontosil was accelerated by unsaturated fatty acids. 5. Linoleic acid up to 3·5mm did not decelerate the generation of NADPH by rat liver soluble fraction, nor the activity of NADPH–cytochrome c reductase of rat liver microsomes. Hepatic microsomal NADPH oxidase activity was slightly enhanced by added linoleic acid. 6. No measurable disappearance of exogenously added linoleic acid occurred when this fatty acid was incubated with rat liver microsomes and an NADPH source. 7. The unsaturated fatty acids used in this study produced type I spectra when added to rat liver microsomes, and affected several microsomal enzyme activities in a manner characteristic of type I ligands.

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