Trifluoperazine increases fatty acid turnover in phospholipids in cultured human fibroblasts

Lipids ◽  
1988 ◽  
Vol 23 (5) ◽  
pp. 419-423 ◽  
Author(s):  
Cecile Mazière ◽  
Jean-Claude Mazière ◽  
Liliana Mora ◽  
Martine Auclair ◽  
Jacques Polonovski
Keyword(s):  
Fatty Acid ◽  
Human Fibroblasts ◽  
Fatty Acid Turnover ◽  
Cultured Human Fibroblasts

scholarly journals Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts

1988 ◽  
Vol 252 (2) ◽  
pp. 375-379 ◽  
Author(s):  
M Trinchera ◽  
U Wiesmann ◽  
M Pitto ◽  
D Acquotti ◽  
R Ghidoni
Keyword(s):  
Fatty Acid ◽  
Human Fibroblasts ◽  
Total Lipid Extract ◽  
Phospholipid Biosynthesis ◽  
Metabolic Fate ◽  
Long Chain Base ◽  
Cultured Human Fibroblasts ◽  
Almost All ◽  
Long Chain ◽  
Ceramide Moiety

Cultured human fibroblasts were fed with two differently labelled sulphatide molecules [one labelled on C-3 of the sphingosine (Sph) moiety [(Sph-3H]sulphatide), the second on C-1 of stearic acid [(stearoyl-14C]sulphatide)], and the intracellular metabolic fate of radioactivity was monitored. Incorporated radioactivity was almost all recovered in the total lipid extract, regardless of the labelling position of the added sulphatide; however, large differences in the level of incorporation occurred among labelled glycosphingolipids. For example, sphingomyelin was present as the major radiolabelled lipid after [Sph-3H]-sulphatide incubation, but was detectable only in trace amounts after [stearoyl-14C]sulphatide administration; in the latter case the radioactivity was located predominantly in glycerophospholipids. From this finding it can be inferred that the free long-chain base (sphingosine) that originates from lysosomal catabolism of sulphatide is mainly, and quite specifically, utilized for sphingomyelin biosynthesis, whereas the ceramide moiety is not; conversely the fatty acid released from ceramide is non-specifically re-utilized for phospholipid biosynthesis.

scholarly journals Modification of the fatty acid composition of cultured human fibroblasts.

1979 ◽  
Vol 20 (4) ◽  
pp. 536-547
Author(s):  
A A Spector ◽  
R E Kiser ◽  
G M Denning ◽  
S W Koh ◽  
L E DeBault
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Human Fibroblasts ◽  
Cultured Human Fibroblasts

scholarly journals Influence of chlorate on proteoglycan biosynthesis by cultured human fibroblasts.

1988 ◽  
Vol 263 (26) ◽  
pp. 12886-12892 ◽  
Author(s):  
H Greve ◽  
Z Cully ◽  
P Blumberg ◽  
H Kresse
Keyword(s):  
Human Fibroblasts ◽  
Cultured Human Fibroblasts

scholarly journals Fatty alcohol metabolism in cultured human fibroblasts. Evidence for a fatty alcohol cycle.

1987 ◽  
Vol 262 (36) ◽  
pp. 17412-17419 ◽  
Author(s):  
W B Rizzo ◽  
D A Craft ◽  
A L Dammann ◽  
M W Phillips
Keyword(s):  
Fatty Alcohol ◽  
Human Fibroblasts ◽  
Alcohol Metabolism ◽  
Cultured Human Fibroblasts

L-iduronidase in cultured human fibroblasts and liver

1971 ◽  
Vol 42 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Reuben Matalon ◽  
J.A. Cifonelli ◽  
Albert Dorfman
Keyword(s):  
Human Fibroblasts ◽  
Cultured Human Fibroblasts

scholarly journals The transport of neutral amino acids in cultured human fibroblasts.

1980 ◽  
Vol 255 (3) ◽  
pp. 929-936 ◽  
Author(s):  
G.C. Gazzola ◽  
V. Dall'Asta ◽  
G.G. Guidotti
Keyword(s):  
Amino Acids ◽  
Human Fibroblasts ◽  
Neutral Amino Acids ◽  
Cultured Human Fibroblasts

scholarly journals Transport of l-Isoleucine by Cultured Human Fibroblasts

1974 ◽  
Vol 249 (11) ◽  
pp. 3430-3435
Author(s):  
Richard E. Hillman ◽  
Elaine F. Otto
Keyword(s):  
Human Fibroblasts ◽  
Cultured Human Fibroblasts

scholarly journals Na/K/Cl cotransport in cultured human fibroblasts.

1985 ◽  
Vol 260 (3) ◽  
pp. 1445-1451
Author(s):  
N E Owen ◽  
M L Prastein
Keyword(s):  
Human Fibroblasts ◽  
Cultured Human Fibroblasts
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