Effects of dietary n−3 polyunsaturated fatty acids on phospholipid composition and calcium transport in mouse cardiac sarcoplasmic reticulum

Lipids ◽  
1989 ◽  
Vol 24 (4) ◽  
pp. 278-285 ◽  
Author(s):  
M. Croset ◽  
J. M. Black ◽  
J. E. Swanson ◽  
J. E. Kinsella
Keyword(s):  
Fatty Acids ◽  
Sarcoplasmic Reticulum ◽  
Polyunsaturated Fatty Acids ◽  
Calcium Transport ◽  
Phospholipid Composition ◽  
Cardiac Sarcoplasmic Reticulum

scholarly journals Direct and indirect modulation of rat cardiac sarcoplasmic reticulum function by n– 3 polyunsaturated fatty acids

2002 ◽  
Vol 538 (1) ◽  
pp. 179-184 ◽  
Author(s):  
S. C. O'Neill ◽  
M. R. Perez ◽  
K. E. Hammond ◽  
E. A. Sheader ◽  
N. Negretti
Keyword(s):  
Fatty Acids ◽  
Sarcoplasmic Reticulum ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Sarcoplasmic Reticulum

Induction of Ca-independent PLA2 and conservation of plasmalogen polyunsaturated fatty acids in diabetic heart

2000 ◽  
Vol 279 (1) ◽  
pp. E25-E32 ◽  
Author(s):  
Jane McHowat ◽  
Michael H. Creer ◽  
Kristine K. Hicks ◽  
Janet H. Jones ◽  
Raetreal McCrory ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Phospholipid Composition ◽  
Phospholipid Metabolism ◽  
Diabetic Rats ◽  
Phospholipid Content ◽  
Diabetic Patients ◽  
Phospholipid Hydrolysis ◽  
Induced Changes ◽  
Docosahexaenoic Acids

Diabetes-induced changes in phospholipase A2(PLA2) activity have been measured in several tissues but are undefined in diabetic myocardium. We measured ventricular PLA2 activity in control, streptozotocin-induced diabetic, and insulin-treated diabetic rats and characterized myocardial phospholipids to determine whether diabetes altered myocardial phospholipid metabolism. Increased membrane-associated Ca2+-independent PLA2 (iPLA2) activity was observed in diabetes that was selective for arachidonylated phospholipids. Increased iPLA2 activity was accompanied by an increase in choline lysophospholipids. Diabetes was associated with marked alterations in the phospholipid composition of the myocardium, characterized by decreases in esterified arachidonic and docosahexaenoic acids and increases in linoleic acid. The decrease in polyunsaturated fatty acids was confined to diacylphospholipids, whereas the relative amount of these fatty acids in plasmalogens was increased. Diabetes-induced changes in PLA2 activity, lysophospholipid production, and alterations in phospholipid composition were all reversed by insulin treatment of diabetic animals. Diabetes-induced changes in membrane phospholipid content and phospholipid hydrolysis may contribute to some of the alterations in myocardial function that are observed in diabetic patients.

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