The effects oftrans fatty acids on fatty acyl Δ5 desaturation by human skin fibroblasts

Lipids ◽  
1984 ◽  
Vol 19 (11) ◽  
pp. 869-874 ◽  
Author(s):  
Miriam D. Rosenthal ◽  
Mark A. Doloresco
Keyword(s):  
Fatty Acids ◽  
Human Skin ◽  
Fatty Acyl ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

Peroxisomal fatty acid β-oxidation in human skin fibroblasts: X-linked adrenoleukodystrophy, a peroxisomal very long chain fatty acyl-CoA synthetase deficiency?

1987 ◽  
Vol 10 (S2) ◽  
pp. 220-224 ◽  
Author(s):  
R. J. A. Wanders ◽  
C. W. T. Van Roermund ◽  
M. J. A. Van Wijland ◽  
J. Heikoop ◽  
A. Van den Put ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Human Skin ◽  
Fatty Acyl ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Synthetase Deficiency ◽  
Long Chain ◽  
Peroxisomal Fatty Acid

scholarly journals Formic acid is a product of the α-oxidation of fatty acids by human skin fibroblasts: deficiency of formic acid production in peroxisome-deficient fibroblasts

1993 ◽  
Vol 292 (2) ◽  
pp. 457-461 ◽  
Author(s):  
A Poulos ◽  
P Sharp ◽  
H Singh ◽  
D W Johnson ◽  
W F Carey ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Formic Acid ◽  
Human Skin ◽  
Acid Production ◽  
Phytanic Acid ◽  
Culture Medium ◽  
Water Soluble ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Beta Oxidation

Human skin fibroblasts in culture can oxidize beta-methyl fatty acids, such as phytanic acid and 3-methylhexadecanoic acid, to CO2 and water-soluble products. The latter are released largely into the culture medium. The major water-soluble product formed from [1-14C]phytanic and [1-14C]3-methylhexadecanoic acids is [14C]formic acid. As phytanic acid and 3-methylhexadecanoic acids contain beta-methyl groups and theoretically cannot be degraded by beta-oxidation, we postulate that formic acid is formed from fatty acids by alpha-oxidation. The marked reduction in formic acid production from beta-methyl fatty acids in peroxisome-deficient skin fibroblasts suggests that peroxisomes are involved in the generation of C1 units.

scholarly journals Conversion of epoxyeicosatrienoic acids (EETs) to chain-shortened epoxy fatty acids by human skin fibroblasts

2000 ◽  
Vol 41 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Xiang Fang ◽  
Terry L. Kaduce ◽  
Mike VanRollins ◽  
Neal L. Weintraub ◽  
Arthur A. Spector
Keyword(s):  
Fatty Acids ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Epoxyeicosatrienoic Acids ◽  
Human Skin Fibroblasts ◽  
Epoxy Fatty Acids
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