Effects of su-13437, a new hypolipidemic drug, upon synthesis in vivo of hepatic and carcass total fatty acids and total cholesterol

Lipids ◽  
1971 ◽  
Vol 6 (7) ◽  
pp. 475-480 ◽  
Author(s):  
Richard J. Cenedella
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Hypolipidemic Drug ◽  
Total Fatty Acids

THE INTERRELATION OF LIPIDS IN THE BLOOD PLASMA OF WHITE LEGHORN COCKERELS

1940 ◽  
Vol 18d (2) ◽  
pp. 49-52 ◽  
Author(s):  
Eldon M. Boyd ◽  
Eleanor L. Clarke
Keyword(s):  
Fatty Acids ◽  
Blood Plasma ◽  
Total Cholesterol ◽  
Total Lipid ◽  
Free Cholesterol ◽  
White Leghorn ◽  
Plasma Total Lipid ◽  
Total Fatty Acids

The blood plasma of 22 healthy, young, white leghorn cockerels was analysed by oxidative micromethods and found to contain the following mean lipid values, in milligrams per 100 ml. of plasma: total lipid 520, neutral fat 225, total fatty acids 361, total cholesterol 100, ester cholesterol 66, free cholesterol 34, phospholipid 155. In general, the amounts of the various lipids were proportionately related to the total lipid.

THE EFFECT OF DIETARY OILS AND FATTY ACIDS ON CHOLESTEROL METABOLISM IN THE RAT

1958 ◽  
Vol 36 (1) ◽  
pp. 433-438 ◽  
Author(s):  
J. D. Wood ◽  
B. B. Migicovsky
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Lauric Acid ◽  
Opposite Effect ◽  
Cholesterol Metabolism ◽  
Coconut Oil ◽  
Liver Cholesterol ◽  
Dietary Oils ◽  
Liver Homogenates

Rats were fed diets containing 20% oils and 9% fatty acids and the effect of these compounds on cholesterol metabolism was studied. Unsaturated oils and fatty acids increased total cholesterol in the liver and stimulated the incorporation of C14-acetate into cholesterol both in vivo and in liver homogenates. Saturated material such as coconut oil and lauric acid had the opposite effect with respect to amount of liver cholesterol and to in vivo incorporation. The saturated material had no significant effect on synthesis in homogenates. The effect of oils in the diet was rapid, the stimulating effect of rapeseed oils being observed after the rats had been placed on the diet for as short a period as 3 days.

THE EFFECT OF DIETARY OILS AND FATTY ACIDS ON CHOLESTEROL METABOLISM IN THE RAT

1958 ◽  
Vol 36 (4) ◽  
pp. 433-438 ◽  
Author(s):  
J. D. Wood ◽  
B. B. Migicovsky
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Lauric Acid ◽  
Opposite Effect ◽  
Cholesterol Metabolism ◽  
Coconut Oil ◽  
Liver Cholesterol ◽  
Dietary Oils ◽  
Liver Homogenates

Rats were fed diets containing 20% oils and 9% fatty acids and the effect of these compounds on cholesterol metabolism was studied. Unsaturated oils and fatty acids increased total cholesterol in the liver and stimulated the incorporation of C14-acetate into cholesterol both in vivo and in liver homogenates. Saturated material such as coconut oil and lauric acid had the opposite effect with respect to amount of liver cholesterol and to in vivo incorporation. The saturated material had no significant effect on synthesis in homogenates. The effect of oils in the diet was rapid, the stimulating effect of rapeseed oils being observed after the rats had been placed on the diet for as short a period as 3 days.

LIPID AND WATER LEVELS IN THE KIDNEYS OF ALBINO RATS BEARING WALKER CARCINOMA 256

1956 ◽  
Vol 34 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Eldon M. Boyd ◽  
Arne O. Tikkala
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Total Lipid ◽  
Free Cholesterol ◽  
Dry Weight ◽  
Water Levels ◽  
Albino Rats ◽  
Total Fatty Acids ◽  
Wet Weight ◽  
Walker Carcinoma

The kidneys of 54 pairs of twin albino rats, one inoculated and one not inoculated with Walker carcinoma 256, were analyzed for water, total lipid, neutral fat, total fatty acids, total cholesterol, ester cholesterol, free cholesterol, and phospholipid, calculated as gm. per 100 gm. nonlipid dry weight. Compared with the kidneys of their nontumor-bearing littermates, the kidneys of tumor-bearing rats exhibited no significant change in wet weight and in concentration of total lipid, neutral fat, total fatty acids, and ester cholesterol. There was a significant increase in concentration of water, total cholesterol, free cholesterol, and phospholipid. The increase was toward concentrations of corresponding elements in Walker carcinoma 256. The changes became evident in animals bearing tumors weighing 20 to 40% or more of host weight.

scholarly journals Dietary regulation of mammary lipogenesis in lactating rats

1980 ◽  
Vol 188 (1) ◽  
pp. 61-65 ◽  
Author(s):  
M R Grigor ◽  
S M Warren
Keyword(s):  
Fatty Acids ◽  
Mammary Gland ◽  
Linseed Oil ◽  
Coconut Oil ◽  
Dietary Lipid ◽  
Dietary Fats ◽  
Peanut Oil ◽  
Dietary Regulation ◽  
Total Fatty Acids

The proportion of medium-chain fatty acids (C8:0, C10:0 and C12:0) in rat milk increased significantly between day 4 and day 8 of lactation and for the remainder of lactation these acids comprised 40-50mol% of the total fatty acids. The milk fatty acid composition from day 8 was markedly dependent on the presence of dietary fat and altered to include the major fatty acids of the fats (peanut oil, coconut oil and linseed oil). The distribution of fatty acids made within the gland, however, was independent of dietary lipid and C8:0, C10:0 and C12:0 acids accounted for over 70% of the fatty acids made. The rates of lipogenesis in both the mammary gland and liver determined in vivo after the administration of 3H2O were affected by the presence of dietary lipid. In the mammary gland the rate for rats fed a diet containing peanut oil for 7 days was only one fifth that for rats fed a fat-free diet. Coconut oil also suppressed lipogenesis. Both dietary fats also suppressed lipogenesis in the liver.

THE LIPID AND WATER CONTENT OF CARCASS, SKELETAL MUSCLE, AND TESTICLE IN THE HOST COMPONENT OF THE ALBINO RAT – WALKER CARCINOMA 256 DUAL ORGANISM AT PROGRESSIVE STAGES OF TUMOR GROWTH

1954 ◽  
Vol 32 (4) ◽  
pp. 359-371 ◽  
Author(s):  
Eldon M. Boyd ◽  
Carl E. Boyd ◽  
J. Gilbert Hill ◽  
Ely Ravinsky
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Tumor Growth ◽  
Total Cholesterol ◽  
Total Lipid ◽  
Free Cholesterol ◽  
Dry Weight ◽  
Total Fatty Acids ◽  
Walker Carcinoma ◽  
Host Component

The objective of this investigation was to find at what stage in the growth of Walker carcinoma 256 appear the shifts in water and lipid levels of host carcass, skeletal muscle, and testicle, noted at or near death of the dual organism by Boyd, Connell, and McEwen (1952). Lipid and water estimations were made upon these tissues, at intervals of one, two, and three weeks of tumor growth, in 35 tumor-bearing and 34 littermate control albino rats. In host carcass, the decline in concentration, per 100 gm. dry weight, of total lipid, neutral fat, and total fatty acids appeared after two weeks of tumor growth, while at or about the same time a rise occurred in the levels of water, total cholesterol, free cholesterol, and phospholipid. In hind limb skeletal muscle of the host, the levels of total lipid, neutral fat, and total fatty acids were lowered, while those of water were elevated, after two and three weeks of tumor growth. In host testicle, the levels of water and lipids were essentially similar to those of the controls. The rise in concentration of water, phospholipid, total cholesterol, and free cholesterol of the host varied, in general, with increase in the T/RC coefficient. Maximal low levels of host total lipid, neutral fat, and total fatty acids were reached at T/RC coefficient values of 20 to 30. Maintenance of total body weight (tumor plus host) was due mainly to accumulation of water in both components. The host component lost dry weight, total lipid, neutral fat, and total fatty acids more rapidly than these accumulated in the tumor in total amount. The smaller loss of total amounts of water, phospholipid, total cholesterol, and free cholesterol in the host was offset by an approximately equal accumulation of these substances in the tumor.

LIPID AND WATER LEVELS IN THE KIDNEYS OF ALBINO RATS BEARING WALKER CARCINOMA 256

1956 ◽  
Vol 34 (2) ◽  
pp. 259-264 ◽  
Author(s):  
Eldon M. Boyd ◽  
Arne O. Tikkala
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Total Lipid ◽  
Free Cholesterol ◽  
Dry Weight ◽  
Water Levels ◽  
Albino Rats ◽  
Total Fatty Acids ◽  
Wet Weight ◽  
Walker Carcinoma

The kidneys of 54 pairs of twin albino rats, one inoculated and one not inoculated with Walker carcinoma 256, were analyzed for water, total lipid, neutral fat, total fatty acids, total cholesterol, ester cholesterol, free cholesterol, and phospholipid, calculated as gm. per 100 gm. nonlipid dry weight. Compared with the kidneys of their nontumor-bearing littermates, the kidneys of tumor-bearing rats exhibited no significant change in wet weight and in concentration of total lipid, neutral fat, total fatty acids, and ester cholesterol. There was a significant increase in concentration of water, total cholesterol, free cholesterol, and phospholipid. The increase was toward concentrations of corresponding elements in Walker carcinoma 256. The changes became evident in animals bearing tumors weighing 20 to 40% or more of host weight.

scholarly journals Identification of Cyclopropane Fatty Acids in Human Plasma after Controlled Dietary Intake of Specific Foods

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3347
Author(s):  
Veronica Lolli ◽  
Margherita Dall’Asta ◽  
Daniele Del Rio ◽  
Augusta Caligiani
Keyword(s):  
Fatty Acids ◽  
Human Plasma ◽  
Dietary Intervention ◽  
Daily Intake ◽  
Cow Milk ◽  
Fatty Acids Composition ◽  
Fatty Acids Profile ◽  
Cyclopropane Fatty Acids ◽  
Total Fatty Acids

Cyclopropane fatty acids (CPFAs) are an investigated class of secondary fatty acids of microbial origin recently identified in foods. Even though the dietary daily intake of this class of compounds it has been recently estimated as not negligible, to date, no studies specifically have investigated their presence in human plasma after consumption of CPFA-rich sources. Therefore, the aims of this study were (i) to test CPFAs concentration in human plasma, thus demonstrating their in vivo bioaccessibility and potential bioavailability, (ii) to investigate a dose-response relationship between medium term chronic intake of CPFAs-rich foods and both CPFAs and plasma total fatty acid profiles in healthy subjects. Ten healthy normal weight adults were enrolled for conducting an in vivo study. Participants were asked to follow a CPFA-controlled diet for 3 weeks, consuming 50 g of Grana Padano cheese (GP) and 250 mL of whole cow milk, which correspond to a total of 22.1 mg of CPFAs. Fasting CPFAs concentration were monitored for eight timepoints during the whole study and plasma total fatty acids composition was determined by GC-MS. CPFAs, mainly dihydrosterculic acid (DHSA), were identified in plasma total fatty acids profile at the beginning of the study and after dietary treatment. A significant (p < 0.05) increase of CPFAs mean plasma concentration (n = 10) were observed at the end of the dietary intervention. Contrarily, the total fatty acids composition of the general plasma fatty acids profile did not significantly change (p ≥ 0.05) during the dietary intervention period. This is the first investigation demonstrating that CPFAs are bioaccessible in vivo and, as expected, their plasmatic concentration may be affected by consumption of CPFAs-rich foods. This research will open the door to further detailed research, which may better elucidate the role of these compounds in human health.

scholarly journals Age-related Increases in Plasma Phosphatidylcholine Hydroperoxide Concentrations in Control Subjects and Patients with Hyperlipidemia

2000 ◽  
Vol 46 (6) ◽  
pp. 822-828 ◽  
Author(s):  
Mikio Kinoshita ◽  
Shinichi Oikawa ◽  
Kyoko Hayasaka ◽  
Akihiro Sekikawa ◽  
Tazuko Nagashima ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Total Cholesterol ◽  
Plasma Lipids ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
In Vivo Evaluation ◽  
Age Related ◽  
Specificity And Sensitivity ◽  
The Mean

Abstract Background: The basal lipid peroxide concentration in the plasma of patients with hyperlipidemia may be related to atherosclerosis. Quantitative determination of lipid peroxides in the plasma is an important step in the overall evaluation of the biochemical processes leading to oxidative injury. Unfortunately, the currently available methods for lipid peroxidation lack specificity and sensitivity. Methods: Hyperlipidemic patients (44 males and 50 females), ages 12–82 years (mean ± SE, 53 ± 2.3 years for males, 58 ± 2.0 years for females, and 56 ± 14 years for total cases), and normolipidemic volunteers (controls, 32 males and 15 females), ages 13–90 years (49 ± 4 years for males, 65 ± 4 years for females, and 55 ± 24 years for total cases), were recruited in the present study. Plasma phosphatidylcholine hydroperoxide (PCOOH) was determined by chemiluminescence-HPLC (CL-HPLC). Results: Plasma PCOOH concentrations increased with age in both controls and hyperlipidemic patients. However, the mean plasma PCOOH concentration in patients with hyperlipidemia (331 ± 19 nmol/L; n = 94) was significantly (P &lt;0.001) higher than in the controls (160 ± 65 nmol/L; n = 47). Plasma PCOOH concentrations were similar in three hyperlipidemic phenotypes: hypercholesterolemia (IIa), hypertriglyceridemia (IV), and combined hyperlipidemia (IIb). The mean plasma PCOOH in patients with treatment-induced normalized plasma lipids was 202 ± 17 nmol/L. There was no significant correlation between plasma PCOOH concentration and total cholesterol, triglycerides, or phospholipids in hyperlipidemic patients. For all subjects, there was a significantly positive correlation between plasma PCOOH and each lipid (total cholesterol, P = 0.0002; triglycerides, P = 0.0137; and phospholipids, P &lt;0.0001). Analysis of fatty acids composition of plasma phosphatidylcholine showed significantly low concentrations of n-6 fatty acids moieties (linoleic acid and arachidonic acid) in patients compared with controls. Conclusions: Our results suggest that an increase in plasma PCOOH in patients with hyperlipidemia may be related to the development and progression of atherosclerosis, particularly in the elderly. Measurement of plasma PCOOH is useful for in vivo evaluation of oxidative stress.

Effects of caloric intake on clearance of injected lipids in rabbits and rats

1961 ◽  
Vol 200 (1) ◽  
pp. 75-79 ◽  
Author(s):  
C. B. Ammerman ◽  
J. M. Iacono ◽  
Lucille P. Wendel ◽  
G. J. Isaac
Keyword(s):  
Fatty Acids ◽  
Adverse Effects ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Caloric Intake ◽  
Normal Serum ◽  
Lipid Phosphorus ◽  
Removal Rates ◽  
Total Fatty Acids ◽  
Lipid Components

Rabbits fasted 3 and 10 days displayed marked increases in serum total fatty acids and total cholesterol, limited increases in lipid phosphorus and a distinct inability to clear intravenously injected triglycerides from the serum. Limited feeding in which rabbits were losing weight over a 10-day period resulted in essentially no change, either in serum lipid components or lipid removal rates. The adverse effects of fasting on serum lipid clearance appeared to be partially overcome by injecting additional glucose at the time of lipid administration, and completely overcome by giving heparin intravenously 15 minutes prior to lipid injection. Rats fasted 4 days showed decreased levels of serum total fatty acids, lipid phosphorus and total cholesterol, but maintained normal rates of serum lipid clearance. Limited-fed rats showed less pronounced decreases in serum total fatty acids, lipid phosphorus and total cholesterol, and also maintained normal serum lipid clearance.

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