Anticataleptic activity of heterocyclic 2-aminoadamantane derivatives

2000 ◽  
Vol 34 (4) ◽  
pp. 189-192
Author(s):  
I. S. Morozov ◽  
E. A. Val'dman ◽  
T. A. Voronina ◽  
L. N. Nerobkova ◽  
N. V. Klimova ◽  
...  
Keyword(s):  
Anticataleptic Activity

6,11-Dihydrodibenzo[b,e]thiepin-11-yl 3-quinuclidinyl ethers: New potential intidepressants and antihistamine agents

1988 ◽  
Vol 53 (8) ◽  
pp. 1806-1811 ◽  
Author(s):  
Zdeněk Polívka ◽  
Jan Metyš ◽  
Miroslav Protiva
Keyword(s):  
Methyl Derivative ◽  
Antihistamine Activity ◽  
Antidepressant Agent ◽  
Anticataleptic Activity

Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-methyl derivative, and further of the methanesulfonates of 2-chloro- and 2-bromo-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 3-quinuclidinol afforded the title ethers I-IV. The 2-methyl compound II (VÚFB-17 088) showed significant antihistamine activity and the 2-chloro compound III (VÚFB-17 089), having antireserpine and anticataleptic activity, proved a potential antidepressant agent.

Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds

1983 ◽  
Vol 48 (2) ◽  
pp. 623-641 ◽  
Author(s):  
Zdeněk Polívka ◽  
Miroslav Rajšner ◽  
Jan Metyš ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Sulfuric Acid ◽  
Title Compound ◽  
Amino Alcohol ◽  
Hydrogen Sulfate ◽  
Geometric Isomers ◽  
Pure Alcohol ◽  
Acid Catalyzed ◽  
Anticataleptic Activity ◽  
Related Compounds

In the reaction of thieno[2,3c]-2-benzothiepin-4(9H)-one (VI) with 1-methyl-4-piperidylmagnesium chloride 7-(1-methyl-4-piperidyl)thieno[2,3-c]-2-benzothiepin-4(9H)-one (VIII) is formed in addition to the expected amino alcohol VII. The title compound I was obtained by the acid catalyzed dehydration of the pure alcohol VII. Compound I (pipethiadene) has outstanding antihistamine, antiserotonin, antireserpine and anticataleptic activity and was recommended to clinical trials as a potential antimigraine agent. For pharmacokinetic and metabolic studies there were prepared the NC2H3 analogue of pipethiadene IV and further, as potential metabolites, the demethyl analogue III, S-oxide X, demethyl S-oxide XI, N-oxide XIII and N,S-dioxide XIV. The Witting reaction of the ketone VI with 3-dimethylaminopropylidenetriphenylphosphorane resulted in a mixture of geometric isomers of 4-(3-dimethylamino-propylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin with the strongly predominating Z-isomer XVI which was isolated from the mixture by crystallization of the hydrogen maleate. The mixture with the predominating Z-isomer XVI was converted by the treatment with 80% sulfuric acid and dilution with water to a mixture with the predominating E-isomer XV (dithiadene) which was isolated by crystallization of the hydrogen sulfate. Some further new thieno[2,3-c]-2-benzothiepin derivatives were synthesized as potential intermediates.

α-(4-Tolyl)dopamine, derivatives and analogues; Synthesis and pharmacological screening

1983 ◽  
Vol 48 (5) ◽  
pp. 1447-1464 ◽  
Author(s):  
Vladimír Valenta ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Antonín Dlabač ◽  
Marie Bartošová ◽  
...  
Keyword(s):  
Acetic Anhydride ◽  
Hydrobromic Acid ◽  
Benzoyl Chloride ◽  
Substitution Reactions ◽  
Low Degree ◽  
Anticataleptic Activity ◽  
Pharmacological Screening ◽  
Higher Doses ◽  
Hydroxyethyl Piperazine ◽  
Antiarrhythmic Effects

The ketone XIII, obtained by Friedel-Crafts reaction of toluene with homoveratroyl chloride, was converted by the Leuckart reaction to the formamido derivative IXb which was used as the starting product for the synthesis of amines IIIb-Vb. Reduction of the ketone XIII gave the alcohol XVI which was treated with hydrogen chloride and afforded the chloro compound XVII. Its substitution reactions with 1-methylpiperazine, 1-(2-hydroxyethyl)piperazine and 1-phenylpiperazine resulted in the piperazines VIb-VIIIb. Acylations of the amine IIIb with acetic anhydride and homoveratroyl chloride gave the amides Xb and XIb which, together with the formamide IXb, were subjected to the Bischler-Napieralski reaction. 3,4-Dihydroisoquinolines XXII-XXIV were obtained and reduced to the 1,2,3,4-tetrahydroisoquinolines XXVb-XXVIIb. Treatment of XXVIIb with formaldehyde afforded the berbine derivative XXVIII. Demethylation of the amine IIIb with hydrobromic acid resulted in the title compound IIIa. Similar demethylations of the dimethoxyamines IVb-VIIIb, XXVb and XXVIb led to the dihydroxyamines IVa-VIIIa, XXVa and XXVIa which are dopamine derivatives. Reaction of Va with benzoyl chloride gave the dibenzoate XXX. The CNS activities of the compounds prepared are of a low degree. Several of them (IIIa-VIa, IIIb-Vb, XXVb) show in higher doses signs of central stimulant action but only for compound IVa an antireserpine effect was proven. The expected anticataleptic activity was found only in a low degree with compound VIIIa; on the contrary, compounds IIIa and XXVa are procataleptogenic. Some compounds (IIIa, IXb, XXVIa, XXVIII) potentiated thiopental. In single cases local anaesthetic, spasmolytic, hypotensive, hypertensive, hypoglycaemic, diuretic and antiarrhythmic effects were observed.

Caffeine withdrawal retains anticataleptic activity butWithania somniferawithdrawal potentiates haloperidol-induced catalepsy in mice

2009 ◽  
Vol 23 (8) ◽  
pp. 724-728 ◽  
Author(s):  
Sanjay Kasture ◽  
Shrikant Barhate ◽  
Mahalaxmi Mohan ◽  
Mauro Ballero ◽  
Cinzia Sanna ◽  
...  
Keyword(s):  
Caffeine Withdrawal ◽  
Anticataleptic Activity

scholarly journals Anticataleptic activity of 2-substituted derivatives of 3(H)-quinazolin-4-one

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Mikael Manvelyan ◽  
Eleonora Manvelyan ◽  
Vladimir Baturin ◽  
Pavel Viktorovich Shamik
Keyword(s):  
Anticataleptic Activity ◽  
Derivatives Of

Anticataleptic activity of cathinone and MDMA (Ecstasy) upon acute and subchronic administration in rat

Synapse ◽  
2003 ◽  
Vol 49 (4) ◽  
pp. 232-238 ◽  
Author(s):  
Mehret Yerdaw Banjaw ◽  
Andreas Mayerhofer ◽  
Werner J. Schmidt
Keyword(s):  
Anticataleptic Activity

ChemInform Abstract: ANTICATALEPTIC ACTIVITY OF 2-AMINOADAMANTANE DERIVATIVES

1980 ◽  
Vol 11 (40) ◽  
Author(s):  
YU. I. VIKHLYAEV ◽  
O. V. UL'YANOVA ◽  
T. A. VORONINA ◽  
G. N. ARTEMENKO ◽  
N. V. KLIMOVA ◽  
...  
Keyword(s):  
Anticataleptic Activity

ChemInform Abstract: Anticataleptic Activity of Heterocyclic Derivatives of 2-Aminoadamantane.

ChemInform ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. no-no
Author(s):  
I. S. Morozov ◽  
E. A. Val'dman ◽  
T. A. Voronina ◽  
L. H. Nerobkova ◽  
N. V. Klimova ◽  
...  
Keyword(s):  
Heterocyclic Derivatives ◽  
Anticataleptic Activity ◽  
Derivatives Of

Cataleptogenic and anticataleptic activity produced by cholecystokinin octapeptides in mice

Neuropeptides ◽  
1985 ◽  
Vol 6 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Tibor Kádár ◽  
Lóránt Borda ◽  
Botond Penke ◽  
Kálmán Kovács ◽  
Gyula Telegdy
Keyword(s):  
Anticataleptic Activity
Sign in / Sign up

Export Citation Format

Share Document