Study of the general toxicity and local irritant action of a 50% dimexide ointment

2000 ◽  
Vol 34 (2) ◽  
pp. 99-100
Author(s):  
E. V. Kompantseva ◽  
M. V. Gavrilin ◽  
G. V. Sen’chukova ◽  
L. I. Karpenya ◽  
L. S. Ushakova ◽  
...  
Keyword(s):  
General Toxicity ◽  
Irritant Action

General toxicity and local irritant action of eucalimin in soft medicinal forms (gel and cream)

2006 ◽  
Vol 40 (7) ◽  
pp. 383-384
Author(s):  
L. V. Krepkova ◽  
V. V. Bortnikova ◽  
O. A. Semkina ◽  
T. A. Sokol’skaya ◽  
V. F. Okhotnikova
Keyword(s):  
General Toxicity ◽  
Irritant Action

STUDYING IRRITANT ACTION OF GENESIS MEDICATION (AGROBIOINTENSIVE)

2018 ◽  
Vol 234 (2) ◽  
pp. 125-129
Author(s):  
A.I. Letkin ◽  
◽  
A.S. Zenkin ◽  
V.M. Vasilkin ◽  
◽  
...  
Keyword(s):  
Irritant Action

Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study

2019 ◽  
Vol 19 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Alessandro Borghi ◽  
Monica Corazza ◽  
Elisa Maietti ◽  
Cataldo Patruno ◽  
Maddalena Napolitano ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Contact Sensitization ◽  
Main Risk Factor ◽  
Nickel Allergy ◽  
Cross Sectional ◽  
Triggering Factor ◽  
Irritant Action ◽  
Allergic Contact

Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial. Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis. Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded. Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis. Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.

scholarly journals Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1126
Author(s):  
Dong-Gu Kim ◽  
Jeonghoon Lee ◽  
Wonnam Kim ◽  
Hyo-Jin An ◽  
Jong-Hyun Lee ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
New Variety ◽  
General Toxicity ◽  
Normal Ranges ◽  
Target Organs ◽  
Adverse Effect Level ◽  
Tract Infections

The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharmacological effects. However, the potential adverse effects of WG have not been revealed yet. This study evaluates the general toxicity of the WG extract through a single and repeated oral dose toxicity study in Sprague-Dawley rats. After single oral dose administration, no significant toxicological changes or mortality was observed up to 5000 mg/kg. Over a 4-week repeated oral dose toxicity study, no adverse effects and target organs were observed up to 5000 mg/kg/day. Over a 13-week repeated oral dose toxicity study, no mortality or toxicological changes involving ophthalmology, water consumption, or hematology were observed up to 5000 mg/kg/day. Although other parameters were changed, the alterations in question were not considered toxicologically significant, since responses remained within normal ranges and were not dose-dependent. In conclusion, the no-observed-adverse-effect level (NOAEL) of WG was higher than 5000 mg/kg/day, and no target organs were identified in rats.

Microbioluminescent study of the general toxicity and mutagenicity of pollutants

2007 ◽  
Vol 43 (4) ◽  
pp. 407-413 ◽  
Author(s):  
I. L. Maslennikova ◽  
N. V. Golyasnaya
Keyword(s):  
General Toxicity

scholarly journals GENERAL TOXICITY AND IMMUNOTOXICITY OF ANTITUMOR AGENTS

1991 ◽  
Vol 16 (SupplementII) ◽  
pp. 21-25
Author(s):  
Masaru KUREBE ◽  
Ken-ichi KIYOMIYA
Keyword(s):  
Antitumor Agents ◽  
General Toxicity

scholarly journals Synthesis of a synthetic analogue for the Sitophilus weevil aggregation pheromone and study on its hygienic and toxicological indexes

2021 ◽  
Vol 117 (2) ◽  
pp. 1
Author(s):  
Gulnara SHAKIRZYANOVA ◽  
Liliya ROMANOVA ◽  
Bahrom BABAEV ◽  
Vladimir АBDUKACHAROV ◽  
Tulkun ISKANDAROV ◽  
...  
Keyword(s):  
Aggregation Pheromone ◽  
Lethal Dose ◽  
Toxicity Testing ◽  
Synthetic Analogue ◽  
Warm Blood ◽  
Dose Ranging ◽  
Practical Limit ◽  
Low Toxicity ◽  
Irritant Action ◽  
The One

The work was initiated to study hygienic and toxicological indices of a synthetic analogue for the Sitophilus weevil aggregation pheromone. The toxicity testing of 5-hydroxy-4-methyl-3-heptanone demonstrated its extremely low toxicity for the warm-blood animals, as compared to the one of the typical pesticides. The average lethal dose of the product per orally administered to the white mice was established to be 4375.0 mg kg-1 LD16 and LD84 being 2225.0 mg kg-1 and 6550.0 mg kg-1, respectively. The average lethal dose for rabbits was 5900.0 mg kg-1 5-hydroxy-4-methyl-3-heptanone proved to have a mild skin and conjunctival irritant action, and equally mild functional cumulation. As to chronic toxicity, the acceptable daily dose of 4.3 mg/person/d was calculated and scientifically substantiated. The odor threshold was determined at the dose ranging from 0.35 to 0.7 mg l-1 with the practical limit ranging from 0.35 to 1.5 mg l-1, taste sensation threshold was found at the dose ranging from 1.0 to 3.0 mg l-1 with the practical limit ranging from 3.0 to 7.0 mg l-1

scholarly journals Influence of Man's Activities Level on the Toxicity of Soddy Podzolic Soil

2020 ◽  
Author(s):  
П.А. Котяк
Keyword(s):  
Podzolic Soil ◽  
Agricultural Practices ◽  
Soddy Podzolic Soil ◽  
Weather Conditions ◽  
Growing Season ◽  
Soil Toxicity ◽  
General Toxicity ◽  
The Status ◽  
Medium Toxicity ◽  
Spring Rape

Представлены результаты исследования уровня общей токсичности и микробного токсикоза дерново-подзолистой глееватой почвы при антропогенной нагрузке. Изучение токсичности почвы особенно актуально в агроценозах, где человек в значительной мере регулирует условия произрастания растений. Использование показателей токсичности при оценке агротехнических приёмов позволяет усовершенствовать существующие технологии, чтобы избежать нежелательных сопутствующих эффектов при агрогенном воздействии на агроэкосистемы. Сравнительный анализ полученных результатов показал, что почва опытного участка в начале вегетации имела класс средней и низкой токсичности (индекс токсичности фактора (ИТФ) от 0,63 до 0,82), а в конце вегетации – класс высокой и средней токсичности (ИТФ от 0,35 до 0,55). Оценка микробиологической токсичности почвы исследуемых вариантов опыта по всхожести семян тест-культуры показала в основном средний уровень микробного токсикоза: 69,75% – на индуцированных образцах, 60,97% – на контрольных образцах. Урожайность зелёной массы ярового рапса находилась на невысоком уровне, что могло быть связано с неблагоприятными погодными условиями вегетационного периода и варьировала в пределах от 76 до 218 ц/га. Проведённые исследования по установлению влияния антропогенной нагрузки на токсический статус дерново-подзолистой почвы в условиях Ярославской области показали, что лучшими характеристиками обладают варианты: система отвальной обработки почвы, фон «Органо-минеральный субстрат + NPK» как с внесением гербицида, так и без его применения при возделывании ярового рапса. В этих условиях снижается общая токсичность почвы, статус микробного токсикоза не меняется, что позволяет сохранять почвенное плодородие, иметь оптимальное фитосанитарное состояние и получать качественный урожай выращиваемых культур. The results of the research of general toxicity level and microbial toxicosis of soddy podzolic gleyic soil at man-caused load are presented. The study of soil toxicity is especially important in agrocenoses, where a person largely regulates the conditions of plant growth. The use of toxicity indicators in assessing agricultural practices allows improving existing technologies in order to avoid undesirable concomitant effects during agrogenic effects on agroecosystems. A comparative analysis of the obtained results showed that the soil of the test area at the beginning of the growing season had a medium and low toxicity class (factor toxicity index (FTI) from 0.63 to 0.82) and at the end of the growing season it had a high and medium toxicity class (FTI from 0.35 to 0.55). Assessment of the microbiological toxicity of the soil of test variants under investigation by seed germination of the test-crop showed mainly the average level of microbial toxicosis: 69.75% on the induced samples, 60.97% on the control samples. The yield of green mass of spring rape was at a low level, which could be associated with unfavorable weather conditions of the growing season and varied from 76 to 218 hkg / ha. Researches conducted to establish influence of man's activities on the toxic status of soddy podzolic soil in the conditions of the Yaroslavl region showed that the best characteristics are options: a system of moldboard tillage, background "Organic-mineral substrate + NPK" both with the herbicide application and without its use in the cultivation of spring rape. Under these conditions the general toxicity of the soil decreases, the status of microbial toxicosis does not change which allows maintaining soil fertility, having an optimal phytosanitary condition and obtaining a quality yield of crops grown.

General Toxicity of Ibuprofen Ointment

2004 ◽  
Vol 38 (4) ◽  
pp. 209-211
Author(s):  
L. I. Karpenya ◽  
M. V. Gavrilin ◽  
L. S. Ushakova ◽  
Yu. A. Ogurtsov
Keyword(s):  
General Toxicity ◽  
Ibuprofen Ointment
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