Role of inhibition of the electrogenic pump in the arrest of neocortical epileptic afterdischarges

2000 ◽  
Vol 32 (3) ◽  
pp. 171-173
Author(s):  
V. M. Okujava ◽  
T. Labakhua ◽  
S. Chipashvili ◽  
L. Mestvirishvili ◽  
Z. Antadze ◽  
...  
Keyword(s):  
Electrogenic Pump ◽  
Epileptic Afterdischarges

scholarly journals What is the role of neurotransmitter systems in cortical seizures?

2008 ◽  
pp. S111-S120
Author(s):  
P Mareš ◽  
H Kubová
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Gabab Receptor ◽  
Age Groups ◽  
Gabab Receptors ◽  
Neurotransmitter Systems ◽  
Metabotropic Glutamate ◽  
Rat Pups ◽  
Epileptic Afterdischarges

Epileptic afterdischarges (ADs) elicited by electrical stimulation of sensorimotor cortical area were used as a model to study the role of neurotransmitter systems in cortical seizures in three age groups of developing rats. Drugs augmenting inhibition mediated by GABAA receptors were found to suppress ADs in all age groups, their activity was usually more marked in younger than in 25-day-old rat pups. Drugs potentiating GABAB receptors exhibit lower efficacy and more complicated developmental profile than GABAA-ergic drugs. Effects of an antagonist of GABAB receptor--marked prolongation of ADs in all three age groups--suggest an important role of GABAB receptors in arrest of cortical seizures. Drugs affecting glutamate receptors exhibit variable effects, usually better expressed in older animals than in 12-day-old ones. No specific role for ionotropic as well as metabotropic glutamate receptors could be predicted. Activation of adenosinergic inhibitory modulatory system also exhibited anticonvulsant action in the present model. All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures.

The role of electrogenic pump inChara corallina

1980 ◽  
Vol 55 (2) ◽  
pp. 149-156 ◽  
Author(s):  
U. Kishimoto ◽  
N. Kami-ike ◽  
Y. Takeuchi
Keyword(s):  
Electrogenic Pump

Reply to: Comments on “The role of electrogenic pump inChara corallina”

1981 ◽  
Vol 59 (2) ◽  
pp. 153-154 ◽  
Author(s):  
Uichiro Kishimoto ◽  
Nobunori Kami-ike ◽  
Yuko Takeuchi
Keyword(s):  
Electrogenic Pump

scholarly journals Proconvulsant Action of Two GABAB Receptor Antagonists Is Age-Dependent

2013 ◽  
pp. S109-S114 ◽  
Author(s):  
P. MAREŠ
Keyword(s):  
Gabab Receptor ◽  
Water Soluble ◽  
Gabab Receptors ◽  
Implanted Electrodes ◽  
Rat Pups ◽  
Age Dependent ◽  
Old Rats ◽  
Gabab Receptor Antagonists ◽  
Epileptic Afterdischarges

Antagonists of GABAB receptors are expected to have proconvulsant action also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABAB receptors at very early stages of maturation.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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