Role of calcium ion in the excitability and electrogenic pump activity of theChara corallina membrane: II. Effects of La3+, EGTA, and calmodulin antagonists on the current-voltage relation

1987 ◽  
Vol 96 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Izuo Tsutsui ◽  
Taka-aki Ohkawa ◽  
Reiko Nagai ◽  
Uichiro Kishimoto
Keyword(s):  
Calcium Ion ◽  
Electrogenic Pump ◽  
Calmodulin Antagonists ◽  
Current Voltage ◽  
Pump Activity ◽  
Current Voltage Relation

scholarly journals Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons

2015 ◽  
Vol 114 (1) ◽  
pp. 707-716 ◽  
Author(s):  
John R. Clay
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Calcium Ion ◽  
Action Potentials ◽  
Ionic Currents ◽  
Model Verification ◽  
Ion Current ◽  
Voltage Step ◽  
Current Voltage ◽  
Current Voltage Relation

The traditional method of recording ionic currents in neurons has been with voltage-clamp steps. Other waveforms such as action potentials (APs) can be used. The AP clamp method reveals contributions of ionic currents that underlie excitability during an AP (Bean BP. Nat Rev Neurosci 8: 451–465, 2007). A novel usage of the method is described in this report. An experimental recording of an AP from the literature is digitized and applied computationally to models of ionic currents. These results are compared with experimental AP-clamp recordings for model verification or, if need be, alterations to the model. The method is applied to the tetrodotoxin-sensitive sodium ion current, INa, and the calcium ion current, ICa, from suprachiasmatic nucleus (SCN) neurons (Jackson AC, Yao GL, Bean BP. J Neurosci 24: 7985–7998, 2004). The latter group reported voltage-step and AP-clamp results for both components. A model of INa is constructed from their voltage-step results. The AP clamp computational methodology applied to that model compares favorably with experiment, other than a modest discrepancy close to the peak of the AP that has not yet been resolved. A model of ICa was constructed from both voltage-step and AP-clamp results of this component. The model employs the Goldman-Hodgkin-Katz equation for the current-voltage relation rather than the traditional linear dependence of this aspect of the model on the Ca2+ driving force. The long-term goal of this work is a mathematical model of the SCN AP. The method is general. It can be applied to any excitable cell.

Current‐voltage relation in a time‐dependent diode

1985 ◽  
Vol 47 (2) ◽  
pp. 115-117 ◽  
Author(s):  
Abraham Kadish ◽  
William Peter ◽  
Michael E. Jones
Keyword(s):  
Time Dependent ◽  
Current Voltage ◽  
Current Voltage Relation

Role of the calcium ion and the disulfide bond in the Burkholderia glumae lipase

2003 ◽  
Vol 22 (5-6) ◽  
pp. 329-338 ◽  
Author(s):  
Mohamed El Khattabi ◽  
Patrick Van Gelder ◽  
Wilbert Bitter ◽  
Jan Tommassen
Keyword(s):  
Disulfide Bond ◽  
Calcium Ion ◽  
Burkholderia Glumae

Evidence of Hysteresis in a New p-i-n-i-p-i-n Amorphous Silicon Device

1997 ◽  
Vol 467 ◽  
Author(s):  
D. Caputo ◽  
G. De Cesare ◽  
F. Palma
Keyword(s):  
Charge Trapping ◽  
Bistable Behavior ◽  
Novel Device ◽  
Voltage Curve ◽  
Current Voltage ◽  
Recombination Processes ◽  
Current Voltage Curve ◽  
Numerical Device ◽  
Silicon Device

ABSTRACTA novel device based on a-Si:H p+-i-n−-i-p−-i-n+ structure, showing a hysteresis in its current-voltage curve is reported. A numerical device model allows to investigate in detail the fundamental role of the two lightly doped n− and p− layers, where charge trapping determines the bistable behavior of the device. The ON condition is mantained until the ambipolar charge injection overcomes the fixed charge. The transition OFF-ON starts when, increasing the applied voltage, one of the two lightly doped layers becomes completely depleted. The transition ON-OFF is, instead, mainly dependent on the recombination processes occurring in the central doped layers. Devices with hysteresis around 2 V and tum-on voltage around 12 are presented.

Effect of calcium chelators on heat coagulation and heat-induced changes of concentrated micellar casein solutions: The role of calcium-ion activity and micellar integrity

2012 ◽  
Vol 26 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Esther de Kort ◽  
Marcel Minor ◽  
Thom Snoeren ◽  
Toon van Hooijdonk ◽  
Erik van der Linden
Keyword(s):  
Calcium Ion ◽  
Micellar Casein ◽  
Ion Activity ◽  
Induced Changes

scholarly journals Modeling Macroscopic Currents of Ion Channels

2021 ◽  
Author(s):  
Di Wu
Keyword(s):  
Open Channel ◽  
Single Channel ◽  
Ion Permeation ◽  
Model Studies ◽  
Proposed Model ◽  
Current Voltage ◽  
Improved Model ◽  
Boltzmann Model ◽  
Channel Properties ◽  
Current Voltage Relation

Ion-channel functions are often studied by the current-voltage relation, which is commonly fitted by the Boltzmann equation, a powerful model widely used nowadays. However, the Boltzmann model is restricted to a two-state ion-permeation process. Here we present an improved model that comprises a flexible number of states and incorporates both the single-channel conductance and the open-channel probability. Employing the channel properties derived from the single-channel recording experiments, the proposed model is able to describe various current-voltage relations, especially the reversal ion-permeation curves showing the inward- and outward-rectifications. We demonstrate the applicability of the proposed model using the published patch-clamp data of BK and MthK potassium channels, and discuss the similarity of the two channels based on the model studies.

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