Effect of the structure of organic phosphonate compounds on chiral separations on derivatized cellulose chiral stationary phase

2002 ◽  
Vol 56 (3-4) ◽  
pp. 143-145 ◽  
Author(s):  
Guo-Sheng Yang ◽  
Lan Zhou ◽  
Du Wei ◽  
Gao-Lan Li ◽  
P. Parrilla vazquez ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations ◽  
Organic Phosphonate

Chiral separations of β-blocking drug substances using the Pirkle-type α-Burke 1 chiral stationary phase

1997 ◽  
Vol 757 (1-2) ◽  
pp. 65-71 ◽  
Author(s):  
Poul Vibholm Petersen ◽  
Jens Ekelund ◽  
Lars Olsen ◽  
Sanna Vinding Ovesen
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations ◽  
Blocking Drug ◽  
Drug Substances

scholarly journals Chiral Separation of Organic Phosphonate Compounds on Cellulose CSP (Chiral Stationary Phase) under Reversed Phase Mode

2003 ◽  
Vol 19 (8) ◽  
pp. 1157-1161 ◽  
Author(s):  
Guo-Sheng YANG ◽  
Piedad Parrilla VAZQUEZ ◽  
Antonia Garrido FRENICH ◽  
Jose L. Martinez VIDAL ◽  
Hassan Y. ABOUL-ENEIN
Keyword(s):  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase ◽  
Reversed Phase ◽  
Organic Phosphonate

A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC

2018 ◽  
Vol 42 (5) ◽  
pp. 3526-3533 ◽  
Author(s):  
Jie Zhou ◽  
Bo Yang ◽  
Jian Tang ◽  
Weihua Tang
Keyword(s):  
Stationary Phase ◽  
Click Chemistry ◽  
Chiral Separation ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Chiral Separations

A cationic cyclodextrin (CD) clicked bilayer chiral stationary phase (CSP) was developed via click chemistry for chiral separations in multimode high-performance chromatography (HPLC).

scholarly journals Direct Enantiomeric Resolution of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives by HPLC

2019 ◽  
Vol 20 (10) ◽  
pp. 2513 ◽  
Author(s):  
Jiayi Sun ◽  
Miyase Gözde Gündüz ◽  
Junyuan Zhang ◽  
Jia Yu ◽  
Xingjie Guo
Keyword(s):  
Stationary Phase ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Reversed Phase ◽  
Chiral Separations ◽  
Racemic Mixture ◽  
Enantiomeric Resolution ◽  
Column Temperature ◽  
Limit Of Quantitation ◽  
Pharmacologically Active

1,4-Dihydropyridine (DHP) scaffold holds an outstanding position with its versatile pharmacological properties among all heterocyclic compounds. Although most of the commercially available DHPs are marketed as a racemic mixture, the chiral center at C-4 can lead to even opposite pharmacological activities between the enantiomers. In the present study, enantioseparation of seventeen DHP structural analogues, consisting of either pharmacologically active or newly synthesized derivatives, (M2-4, MD5, HM2, HM10, CE5, N11, N10, N7, M11, MC6-8, MC13, MD23, and 42IIP) by high-performance liquid chromatography was investigated using immobilized polysaccharide-based chiral stationary phase, Chiralpak IC column. Due to the solvent versatility of the covalently immobilized chiral stationary phase in enantiomer separation, multiple elution modes including standard normal phase, nonstandard mobile phase, and reversed phase were used to expand the possibility to find the optimum enantioselective conditions for the tested analytes. Under appropriate separation conditions, complete enantiomeric separation was obtained for nearly all compounds except MC6-8 and MC13 which contained two chiral centers. Additionally, the effects of the polar modifier, the additive, and column temperature on the chiral recognition were evaluated. The thermodynamic parameters calculated according to the linear van’t Hoff equation indicated that the chiral separations in this study were enthalpy-driven or entropy-driven. Some parameters of method validation such as linearity, limit of quantitation, and repeatability were also measured for all studied compounds to prove the reliability of the method.

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