Stereochemical resolution of racemates, in HPLC, using a chiral stationary phase based upon immobilized α-chymotrypsin. I. Structural chiral separations

1999 ◽  
Vol 49 (11-12) ◽  
pp. 595-605 ◽  
Author(s):  
G. Félix ◽  
V. Descorps
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations

Chiral separations of β-blocking drug substances using the Pirkle-type α-Burke 1 chiral stationary phase

1997 ◽  
Vol 757 (1-2) ◽  
pp. 65-71 ◽  
Author(s):  
Poul Vibholm Petersen ◽  
Jens Ekelund ◽  
Lars Olsen ◽  
Sanna Vinding Ovesen
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations ◽  
Blocking Drug ◽  
Drug Substances

A cationic cyclodextrin clicked bilayer chiral stationary phase for versatile chiral separation in HPLC

2018 ◽  
Vol 42 (5) ◽  
pp. 3526-3533 ◽  
Author(s):  
Jie Zhou ◽  
Bo Yang ◽  
Jian Tang ◽  
Weihua Tang
Keyword(s):  
Stationary Phase ◽  
Click Chemistry ◽  
Chiral Separation ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Chiral Separations

A cationic cyclodextrin (CD) clicked bilayer chiral stationary phase (CSP) was developed via click chemistry for chiral separations in multimode high-performance chromatography (HPLC).

Effect of the structure of organic phosphonate compounds on chiral separations on derivatized cellulose chiral stationary phase

2002 ◽  
Vol 56 (3-4) ◽  
pp. 143-145 ◽  
Author(s):  
Guo-Sheng Yang ◽  
Lan Zhou ◽  
Du Wei ◽  
Gao-Lan Li ◽  
P. Parrilla vazquez ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations ◽  
Organic Phosphonate

scholarly journals Direct Enantiomeric Resolution of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives by HPLC

2019 ◽  
Vol 20 (10) ◽  
pp. 2513 ◽  
Author(s):  
Jiayi Sun ◽  
Miyase Gözde Gündüz ◽  
Junyuan Zhang ◽  
Jia Yu ◽  
Xingjie Guo
Keyword(s):  
Stationary Phase ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Reversed Phase ◽  
Chiral Separations ◽  
Racemic Mixture ◽  
Enantiomeric Resolution ◽  
Column Temperature ◽  
Limit Of Quantitation ◽  
Pharmacologically Active

1,4-Dihydropyridine (DHP) scaffold holds an outstanding position with its versatile pharmacological properties among all heterocyclic compounds. Although most of the commercially available DHPs are marketed as a racemic mixture, the chiral center at C-4 can lead to even opposite pharmacological activities between the enantiomers. In the present study, enantioseparation of seventeen DHP structural analogues, consisting of either pharmacologically active or newly synthesized derivatives, (M2-4, MD5, HM2, HM10, CE5, N11, N10, N7, M11, MC6-8, MC13, MD23, and 42IIP) by high-performance liquid chromatography was investigated using immobilized polysaccharide-based chiral stationary phase, Chiralpak IC column. Due to the solvent versatility of the covalently immobilized chiral stationary phase in enantiomer separation, multiple elution modes including standard normal phase, nonstandard mobile phase, and reversed phase were used to expand the possibility to find the optimum enantioselective conditions for the tested analytes. Under appropriate separation conditions, complete enantiomeric separation was obtained for nearly all compounds except MC6-8 and MC13 which contained two chiral centers. Additionally, the effects of the polar modifier, the additive, and column temperature on the chiral recognition were evaluated. The thermodynamic parameters calculated according to the linear van’t Hoff equation indicated that the chiral separations in this study were enthalpy-driven or entropy-driven. Some parameters of method validation such as linearity, limit of quantitation, and repeatability were also measured for all studied compounds to prove the reliability of the method.

The direct chiral separations of fungicide enantiomers on amylopectin based chiral stationary phase by HPLC

Chirality ◽  
2006 ◽  
Vol 19 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Peng Wang ◽  
Donghui Liu ◽  
Shuren Jiang ◽  
Xu Gu ◽  
Zhiqiang Zhou
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Separations
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