RP-HPLC determination and pharmacokinetic study of mangiferin in rat plasma after taking traditional chinese medicinal-preparation: Zhimu decoction

2003 ◽  
Vol 57 (11-12) ◽  
pp. 767-770 ◽  
Author(s):  
Y. -J. Li ◽  
K. -S. Bi
Keyword(s):  
Pharmacokinetic Study ◽  
Medicinal Preparation ◽  
Rat Plasma ◽  
Hplc Determination ◽  
Rp Hplc

Development and validation of an RP-HPLC method for the quantitation of Orteronel (TAK-700), a CYP17A1 enzyme inhibitor, in rat plasma and its application to a pharmacokinetic study

2013 ◽  
Vol 27 (12) ◽  
pp. 1590-1594 ◽  
Author(s):  
Avinash Kumar ◽  
Vijay Kumar S ◽  
Sandip Gurav ◽  
Mohd Zainuddin ◽  
Purushottam Dewang ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Enzyme Inhibitor ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation

A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study

2010 ◽  
Vol 25 (5) ◽  
pp. 542-546 ◽  
Author(s):  
Xiao-Li Song ◽  
Qing-Ying Zhang ◽  
Zhe-Ming Wang ◽  
Hong-Zheng Fu ◽  
Rui-Qin Qian
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

Validated RP-HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats

2012 ◽  
Vol 27 (2) ◽  
pp. 203-207 ◽  
Author(s):  
S. Vijay Kumar ◽  
G. Rudresha ◽  
Sandip Gurav ◽  
Mohd Zainuddin ◽  
Purushottam Dewang ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Rp Hplc

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 41 (10) ◽  
pp. 692-697 ◽  
Author(s):  
Archana Khosa ◽  
Kowthavarapu V. Krishna ◽  
Ranendra N. Saha ◽  
Sunil K. Dubey ◽  
Satish Reddi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

scholarly journals Quantitative estimation of cilnidipine and valsartan in rat plasma by RP-HPLC: its pharmacokinetic application

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ramanlal N. Kachave ◽  
Shanker S. Yelmame ◽  
Akshay G. Mundhe
Keyword(s):  
Pharmacokinetic Study ◽  
Present Method ◽  
Mobile Phase ◽  
Chromatographic Method ◽  
Quantitative Estimation ◽  
Antihypertensive Agents ◽  
Rat Plasma ◽  
Time Intervals ◽  
Rp Hplc ◽  
Treatment Of Hypertension

Abstract Background Cilnidipine (CLD) and valsartan (VAL) are antihypertensive agents used in the treatment of hypertension. So, pharmacokinetic study of CLD and VAL in rat plasma was carried out using chromatographic method. The chromatographic separation was performed on the Inertsil ODS column, using mobile phase methanol: water 85:15 v/v (pH 3.0) at the flow rate of 1.1 mL/min., detected at 254 nm. Result Cilnidipine (CLD) (1 mg/kg) and valsartan (VAL) (1 mg/kg) was administered orally in rats, and blood samples were collected at time intervals of 0, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, and 24 h after dosing. The retention time of plasma, CLD, and VAL was found to be 2.7, 6.6, and 4.3 min, respectively. The result was validated statistically and by recovery studies. Linearity was acceptable in the range of 1–5 and 8–40 μg/mL for CLD and VAL, respectively. Maximal concentration (Cmax) of CLD and VAL was observed to be 338 ± 13.85 and 1282.21 ± 39.23 (ng/mL). The half-life of CLD and VAL was found to be 1.08 ± 0.21 and 1.43 ± 0.12 h, respectively. Conclusion The present method was successfully applied to the pharmacokinetic study of cilnidipine (CLD) and valsartan (VAL) in rat plasma after oral administration.

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