Aminoglycoside suppression at UAG, UAA and UGA codons inEscherichia coli and human tissue culture cells

1989 ◽  
Vol 217 (2-3) ◽  
pp. 411-418 ◽  
Author(s):  
Robin Martin ◽  
Anne E. Mogg ◽  
Louise A. Heywood ◽  
Lars Nitschke ◽  
Julian F. Burke
Acta Naturae ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 101-105
Author(s):  
Sidney Altman ◽  
Carlos Angele-Martinez

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.


1972 ◽  
Vol 69 (2) ◽  
pp. 452-455 ◽  
Author(s):  
B. Fridlender ◽  
M. Fry ◽  
A. Bolden ◽  
A. Weissbach

Methods ◽  
1992 ◽  
Vol 4 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Richard A. Swirski ◽  
David Van Den Berg ◽  
Andrew J.M. Murphy ◽  
Claire M. Lambert ◽  
Errol C. Friedberg ◽  
...  

2017 ◽  
Vol 28 (11) ◽  
pp. 1409-1411 ◽  
Author(s):  
David G. Drubin ◽  
Anthony A. Hyman

Human tissue culture cells have long been a staple of molecular and cell biology research. However, although these cells are derived from humans, they have often lost considerable aspects of natural physiological function. Here we argue that combined advances in genome editing, stem cell production, and organoid derivation from stem cells represent a revolution in cell biology. These advances have important ramifications for the study of basic cell biology mechanisms, as well as for the ways in which discoveries in mechanisms are translated into understanding of disease.


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