Expression of type 1 metabotropic glutamate receptors in Purkinje neurons of mice

1997 ◽  
Vol 29 (1) ◽  
pp. 28-31
Author(s):  
V. Matyash ◽  
A. Verkhratsky
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Purkinje Neurons ◽  
Metabotropic Glutamate

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

2015 ◽  
Vol 41 (4) ◽  
pp. 924-932 ◽  
Author(s):  
Maria Rosaria Romano ◽  
Luisa Di Menna ◽  
Pamela Scarselli ◽  
Giada Mascio ◽  
Michele Madonna ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

scholarly journals The origin of physiological local mGluR1 supralinear Ca2+ signals in cerebellar Purkinje neurons

2019 ◽  
Author(s):  
Karima Ait Ouares ◽  
Marco Canepari
Keyword(s):  
Synaptic Plasticity ◽  
Metabotropic Glutamate Receptors ◽  
Purkinje Neurons ◽  
Parallel Fibre ◽  
Climbing Fibre ◽  
Metabotropic Glutamate ◽  
Type K ◽  
Cerebellar Purkinje Neurons ◽  
Crucial Parameter

SUMMARYIn Purkinje neurons, the climbing fibre (CF) input provides a signal to parallel fibre (PF) synapses triggering PF synaptic plasticity. This supralinear Ca2+ signal, co-localised with the PF Ca2+ influx, occurs when PF activity precedes the CF input. Using membrane potential (Vm) and Ca2+ imaging, we identified the biophysical determinants of these supralinear Ca2+ signals. The CF-associated Ca2+ influx is mediated by T-type or by P/Q-type Ca2+ channels, depending on whether the dendritic Vm is hyperpolarised or depolarised. The resulting Ca2+ elevation is locally amplified by saturation of the endogenous Ca2+ buffer produced by the PF-associated Ca2+ influx, in particular by the slow Ca2+ influx mediated by type-1 metabotropic glutamate receptors (mGluR1s). When the dendrite is hyperpolarised, mGluR1s boost neighbouring T-type channels providing a mechanism for local coincident detection of PF-CF activity. In contrast, when the dendrite is depolarised, mGluR1s increase dendritic excitability by inactivating A-type K+ channels, but this phenomenon is not restricted to the activated PF synapses. Thus, Vm is likely a crucial parameter in determining PF synaptic plasticity and the occurrence of hyperpolarisation episodes is expected to play an important role in motor learning.

Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia

2016 ◽  
Vol 263 (11) ◽  
pp. 2179-2187 ◽  
Author(s):  
Kenji Ishibashi ◽  
Yoshiharu Miura ◽  
Kinya Ishikawa ◽  
Ming-Rong Zhang ◽  
Jun Toyohara ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Cerebellar Ataxia ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission

2001 ◽  
Vol 17 (6) ◽  
pp. 1071-1083 ◽  
Author(s):  
Giuseppe Battaglia ◽  
Valeria Bruno ◽  
Antonio Pisani ◽  
Diego Centonze ◽  
Maria Vincenza Catania ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Gabaergic Transmission ◽  
Metabotropic Glutamate ◽  
Selective Blockade

Estrogen Receptors and Type 1 Metabotropic Glutamate Receptors Are Interdependent in Protecting Cortical Neurons against β-Amyloid Toxicity

2011 ◽  
Vol 81 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Simona Federica Spampinato ◽  
Gemma Molinaro ◽  
Sara Merlo ◽  
Luisa Iacovelli ◽  
Filippo Caraci ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Glutamate Receptors ◽  
Cortical Neurons ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Amyloid Toxicity ◽  
Β Amyloid

scholarly journals Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABA ergic synapses in the rodent cerebellar cortex

2014 ◽  
Vol 41 (2) ◽  
pp. 157-167 ◽  
Author(s):  
Mahnaz Mansouri ◽  
Yu Kasugai ◽  
Yugo Fukazawa ◽  
Federica Bertaso ◽  
Fabrice Raynaud ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Cerebellar Cortex ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate
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