Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission

2001 ◽  
Vol 17 (6) ◽  
pp. 1071-1083 ◽  
Author(s):  
Giuseppe Battaglia ◽  
Valeria Bruno ◽  
Antonio Pisani ◽  
Diego Centonze ◽  
Maria Vincenza Catania ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Gabaergic Transmission ◽  
Metabotropic Glutamate ◽  
Selective Blockade

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

2015 ◽  
Vol 41 (4) ◽  
pp. 924-932 ◽  
Author(s):  
Maria Rosaria Romano ◽  
Luisa Di Menna ◽  
Pamela Scarselli ◽  
Giada Mascio ◽  
Michele Madonna ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Stimulation of metabotropic glutamate receptors in the dorsomedial hypothalamus elevates heart rate in rats

1996 ◽  
Vol 270 (5) ◽  
pp. R1115-R1121 ◽  
Author(s):  
J. DiMicco ◽  
A. J. Monroe
Keyword(s):  
Heart Rate ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Cardiovascular Effects ◽  
Nmda Receptor Antagonist ◽  
Dorsomedial Hypothalamus ◽  
Metabotropic Glutamate ◽  
Selective Blockade ◽  
Stimulation Of

This study examined the potential role of metabotropic glutamate receptors (mGluRs) in the dorsomedial hypothalamus (DMH) by assessing the cardiovascular effects of microinjecting the agonist trans-1-aminocyclopentane-1, 3- dicarboxylate (tACPD) into this region in urethan-anesthetized rats. Dose-related tachycardia was observed after unilateral microinjection of 1S 3R-tACPD (10-200 pmol/50nl) but not after injection of 1R, 3S-tACPD, which has been reported to have little or no activity at mGluRs. Microinjection of dihydroxyphenylglycine, an agonist at mGluRs linked to phosphoinositide hydrolysis, resulted in increases in heart rate that correlated closely in magnitude to those seen after injection of the same dose of 1S, 3R-tACPD. Coinjection of the N-methyl-D-aspartate (NMDA) receptor antagonist DL-2- amino-5-phosphonopentanoic acid, given at doses shown to elicit selective blockade of NMDA ionotropic glutamate receptors, reduced the increase in heart rate evoked by 100 pmol 1S, 3R-tACPD alone. Thus the DMH contains functional mGluRs, and stimulation of these receptors activates the same sympathoexcitatory mechanism characterized previously to provoke dose-related tachycardia.

Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia

2016 ◽  
Vol 263 (11) ◽  
pp. 2179-2187 ◽  
Author(s):  
Kenji Ishibashi ◽  
Yoshiharu Miura ◽  
Kinya Ishikawa ◽  
Ming-Rong Zhang ◽  
Jun Toyohara ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Cerebellar Ataxia ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Estrogen Receptors and Type 1 Metabotropic Glutamate Receptors Are Interdependent in Protecting Cortical Neurons against β-Amyloid Toxicity

2011 ◽  
Vol 81 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Simona Federica Spampinato ◽  
Gemma Molinaro ◽  
Sara Merlo ◽  
Luisa Iacovelli ◽  
Filippo Caraci ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Glutamate Receptors ◽  
Cortical Neurons ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Amyloid Toxicity ◽  
Β Amyloid
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