Lipid peroxidation and antioxidant enzymes in the brain of rats exposed to acute emotional stress: Effect of interleukin-1β

1995 ◽  
Vol 120 (3) ◽  
pp. 884-886 ◽  
Author(s):  
S. S. Pertsov ◽  
T. S. Balashova ◽  
A. A. Kubatiev ◽  
A. S. Sosnovskii ◽  
G. V. Pirogova ◽  
...  
1997 ◽  
Vol 124 (2) ◽  
pp. 747-750
Author(s):  
S. S. Pertsov ◽  
A. S. Sosnovskii ◽  
A. A. Kubatiev ◽  
G. V. Pirogova

1994 ◽  
Vol 118 (4) ◽  
pp. 1085-1087
Author(s):  
M. L. Kuklei ◽  
S. L. Stvolinskii ◽  
A. A. Boldyrev ◽  
I. V. Gannushkina

Author(s):  
Anna V. Novoseletskaya ◽  
Nina M. Kiseleva

A comparative study of the effect of the thymus hormone thymulin and thymus peptides (thymosin fraction 5) on the content of monoamines and their metabolites in the frontal cortex, striatum, adjacent nucleus, hypothalamus, hippocampus of the brain of Wistar rats, by high performance liquid chromatography, was performed. The hormone and peptides of the thymus were found to reduce emotional stress during functional impairment ofthe avoidance reaction and improved adaptation under stressful conditions in rats, which indicates the anti-stress effect of thymus hormones. The positive effect of the hormone and peptides of the thymus were manifested in a change in the balance of serotonin and norepinephrine in favor of the former in the hypothalamus and frontal cortex.


2014 ◽  
Vol 8 (4) ◽  
pp. 331-335 ◽  
Author(s):  
S. S. Pertsov ◽  
L. S. Kalinichenko ◽  
E. V. Koplik ◽  
L. G. Nagler ◽  
E. S. Alinkina ◽  
...  

2003 ◽  
Vol 22 (12) ◽  
pp. 653-658 ◽  
Author(s):  
Pradeep K Shukla ◽  
Vinay K Khanna ◽  
Mohd Y Khan ◽  
Rikhab C Srimal

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.


2010 ◽  
Vol 150 (1) ◽  
pp. 9-12 ◽  
Author(s):  
S. S. Pertsov ◽  
E. V. Koplik ◽  
L. S. Kalinichenko ◽  
A. S. Simbirtsev

1985 ◽  
Vol 15 (4) ◽  
pp. 284-290 ◽  
Author(s):  
N. N. Bogolepov ◽  
L. B. Verbitskaya ◽  
T. I. Belova ◽  
K. V. Sudakov

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