Effects of adrenal glands on bone marrow hemopoietic microenvironment

1999 ◽  
Vol 128 (5) ◽  
pp. 1169-1173
Author(s):  
I. A. Khlusov ◽  
T. Yu. Raskovalova ◽  
E. V. Kirienkova ◽  
A. M. Dygai
Keyword(s):  
Bone Marrow ◽  
Adrenal Glands ◽  
Hemopoietic Microenvironment

scholarly journals Green Brazilian Propolis Action on Macrophages and Lymphoid Organs of Chronically Stressed Mice

2008 ◽  
Vol 5 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Fabiane Missima ◽  
José Maurício Sforcin
Keyword(s):  
Bone Marrow ◽  
Adrenal Glands ◽  
Well Being ◽  
Peritoneal Macrophages ◽  
Histopathological Analysis ◽  
No Production ◽  
Generic Term ◽  
Brazilian Propolis ◽  
Immunomodulatory Action ◽  
New Research

Stress is a generic term that summarizes how psychosocial and environmental factors influence physical and mental well-being. The interaction between stress and immunity has been widely investigated, involving the neuroendocrine system and several organs. Assays using natural products in stress models deserve further investigation. Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory. The aim of this study was to evaluate if and how propolis activated macrophages in BALB/c mice submitted to immobilization stress, as well as the histopathological analysis of the thymus, bone marrow, spleen and adrenal glands. Stressed mice showed a higher hydrogen peroxide (H2O2) generation by peritoneal macrophages, and propolis treatment potentiated H2O2generation and inhibited nitric oxide (NO) production by these cells. Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen. Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress.

scholarly journals Studies of the Hemopoietic Microenvironment. I. Changes in the Microvascular System and Stroma During Erythropoietic Regeneration and Suppression in the Spleens of CF1 Mice

Blood ◽  
1972 ◽  
Vol 39 (5) ◽  
pp. 697-712 ◽  
Author(s):  
Robert S. McCuskey ◽  
Howard A. Meineke ◽  
Samuel F. Townsend
Keyword(s):  
Bone Marrow ◽  
Blood Flow ◽  
Linear Velocity ◽  
Proliferating Cells ◽  
Hemopoietic Microenvironment ◽  
Murine Spleen ◽  
Flow Through ◽  
Tissue Compartments ◽  
Red Pulp

Abstract Specific alterations in the microvascular and connective tissue compartments of the hemopoietic microenvironment have been examined during erythropoietic regeneration and suppression in the murine spleen and bone marrow using in vivo microscopic and histochemical methods. The results have confirmed the concept of specific hemopoietic microenvironments and have demonstrated specific alterations in the microenvironment during erythropoietic stimulation and repression. Elevated erythropoiesis in the splenic red pulp is accompanied by an elevation in blood flow through the microvascular system. Both the linear velocity of flow and the number of sinusoids with blood flow in them increased significantly. In contrast, erythropoietic repression was accompanied by a decreased linear velocity of blood flow, as well as a marked increase in the amount of blood being stored in the splenic sinusoids. This also was the picture when diffuse granulopoiesis was present in the red pulp, or when granuloid or undifferentiated colonies were present. The chemical composition of the stroma in the spleen and bone marrow also varied during states of hemopoietic activity and, in addition, there were differences in the composition of the stroma between these two organs. In both organs, foci of early proliferating cells were enveloped by a coating of sulfated acid mucopolysaccharide. This coat persisted on cells in later stages of granulopoiesis but not on cells in the later stages of erythropoiesis. The latter were enveloped with a coating of neutral mucopolysaccharide. A tentative hypothesis to explain the mechanisms involved in producing these changes is discussed.

scholarly journals Haemolytic anaemia in rhesus monkeys induced by methylcellulose

1982 ◽  
Vol 16 (4) ◽  
pp. 310-313 ◽  
Author(s):  
Chester A. Glomski ◽  
Chung-Faye Chao ◽  
Gary B. Zuckerman
Keyword(s):  
Bone Marrow ◽  
Rhesus Monkey ◽  
Haemolytic Anaemia ◽  
Rhesus Monkeys ◽  
Adrenal Glands ◽  
Specific Response ◽  
Histological Response ◽  
Phagocytic Cells ◽  
Glomerular Endothelium ◽  
Species Specific

The rhesus monkey was evaluated in its haemopoietic and histological response to intraperitoneal injections of methylcellulose. The haematologic alterations included a mild haemolytic anaemia, lymphofaenia, monocytosis, a shortened survival of Cr51-labelled autologous erythrocytes (17·1 vs 13·3 days, P<0·025) and normoblastic hyperplasia of the bone marrow. There was a diffuse sequestration of the polymer in the phagocytic cells of the spleen, liver, bone marrow, lymph nodes and adrenal glands. The renal glomerular endothelium also consistently stored this material. Overt splenomegaly was not induced. The monkey appears to present, along with other animals, a rather species-specific response to methylcellulose that is accompanied by fundamental responses observable in all subjects.

scholarly journals Chondroitin 6-sulfate proteoglycans constructing hemopoietic microenvironment in bone marrow.

1987 ◽  
Vol 36 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Kayoko Oguri ◽  
Eiko Okayama ◽  
Bruce Caterson ◽  
Minoru Okayama
Keyword(s):  
Bone Marrow ◽  
Hemopoietic Microenvironment

scholarly journals Sl/Sld mouse bone marrow stroma in vitro contains an active radiation- sensitive inhibitor of normal hemopoiesis

Blood ◽  
1986 ◽  
Vol 68 (6) ◽  
pp. 1201-1206
Author(s):  
KS Zuckerman ◽  
CW Prince ◽  
M Ribadeneira
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Inhibitory Effect ◽  
Mouse Bone Marrow ◽  
Hemopoietic Microenvironment ◽  
Hemopoietic Progenitor ◽  
Marrow Cultures ◽  
Marrow Cells

Sl/Sld mice have a defective hemopoietic microenvironment. It has been assumed, based upon previous studies, that the primary abnormality in these mice is simply lack of a necessary supportive or inductive material within the hemopoietic stroma. We used in vitro long-term bone marrow cultures to characterize further the nature of the hemopoietic microenvironmental defect in Sl/Sld mice. Sl/Sld mouse bone marrow cells consistently produced less than 10% of the total hemopoietic cells and multipotent and unipotent hemopoietic progenitor cells produced in cultures of marrow from normal, congenic +/+ mice. If fresh Sl/Sld and +/+ marrow cells were mixed prior to establishing long-term marrow cultures, there was a direct correlation between number of Sl/Sld cells added and degree of inhibition of +/+ hemopoiesis. A pre- established, confluent Sl/Sld adherent stromal layer inhibited hemopoiesis by fresh +/+ marrow cells by nearly 70%, as compared with dishes with irradiated +/+ or no stroma. This inhibitory effect was abrogated by irradiation of the Sl/Sld stroma prior to addition of the fresh +/+ marrow cells. Similarly, unirradiated, but not 9 to 200 Gy irradiated Sl/Sld stroma inhibited proliferation of the factor- dependent FDC-P1 hemopoietic progenitor cell line. Thus, the Sl/Sld hemopoietic microenvironment actively inhibits hemopoiesis in vitro, and this inhibition can be at least partially eliminated by irradiation of the Sl/Sld stroma.

scholarly journals UNUSUAL METASTASES OF LUNG CANCER: BULBUS OCULI AND MAXILLARY SINUS

2015 ◽  
Vol 37 (3) ◽  
pp. 231-232 ◽  
Author(s):  
I Ates ◽  
O Yazici ◽  
H Ates ◽  
N Ozdemir ◽  
N Zengin
Keyword(s):  
Lung Cancer ◽  
Bone Marrow ◽  
Case Report ◽  
Parotid Gland ◽  
Lung Adenocarcinoma ◽  
Maxillary Sinus ◽  
Adrenal Glands ◽  
The Body ◽  
Unusual Metastases ◽  
The Brain

Lung adenocarcinoma often makes metastasis to the brain, liver, kidneys, bone, bone marrow and adrenal glands. It can also make metastasis to other parts of the body rarely for example eye, nose, parotid gland and paranasal sinus. We did not encounter with combined ocular bulbus and the maxillary sinus metastases of lung cancer in the accessible literature. In this case report, a patient who was combined ocular bulbus and the maxillary sinus metastases of lung adenocarcinoma will be discussed.

scholarly journals Generalized cryptococcosis of the internal organs

2020 ◽  
pp. 123-129
Author(s):  
O. V. Konoplyanik ◽  
E. O. Kulchik ◽  
N. V. Husakova ◽  
A. V. Homolyako
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Clinical Case ◽  
Adrenal Glands ◽  
Morphological Changes ◽  
Pia Mater ◽  
Internal Organs

The article presents a clinical case of generalized cryptococcosis of the internal organs in a 62-year-old man and describes morphological changes in the internal organs associated with diffuse fungal dissemination. A feature of the case is multiple damage to the internal organs: lungs, brain and pia mater, liver, kidneys, lymph nodes, spleen, adrenal glands and bone marrow.

scholarly journals HEMATOPOIESIS IN PANTOTHENIC ACID-DEFICIENT RATS

Blood ◽  
1947 ◽  
Vol 2 (5) ◽  
pp. 451-462 ◽  
Author(s):  
L. L. ASHBURN ◽  
FLOYD S. DAFT ◽  
R. R. FAULKNER
Keyword(s):  
Bone Marrow ◽  
Folic Acid ◽  
Lymphoid Tissue ◽  
Marked Reduction ◽  
Adrenal Glands ◽  
Leukocyte Count ◽  
Pantothenic Acid ◽  
Lymphoid Hyperplasia ◽  
Variable Degree ◽  
Erythroid Cells

Abstract Rats fed a purified diet low in pantothenic acid developed granulocytopenia and anemia singly or in combination. In the former, the marrow showed marked depletion of granulocytes, particularly of the more mature cells, and a slight increase in erythroid cells. In combined granulocytopenia and anemia the granulocytes of the marrow were still further reduced and the erythroid cells were also depleted. Marked reduction in the number of megakaryocytes occurred both in the granulocytopenic and in the granulocytopenic and anemic rats. Purpura was noted grossly in about 25 per cent of the rats of both groups. In anemia without accompanying granulocytopenia the marrow granulocytes showed slight to moderate depletion, whereas the erythroid index (mean) was not significantly lowered. Megakaryocytes were moderately reduced. Lymphoid tissue—spleen, thymus, and cervical nodes—showed atrophy of variable degree, most marked in the thymus. Adrenal glands showed marked depletion of cortical lipoids and rarely hemorrhage and necrosis. Following treatment with combined folic acid, pantothenic acid, and niacinamide, granulocytopenic rats responded by showing a prompt rise in lymphocyte and polymorphonuclear leukocyte count, marked granulocyte response of the bone marrow, increased splenic hematopoiesis, lymphoid hyperplasia, and increased lipoid content of the adrenal glands.

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