Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and Black African populations

1989 ◽  
Vol 30 (5) ◽  
pp. 350-360 ◽  
Author(s):  
Nada Ghanem ◽  
Catherine Buresi ◽  
Jean-Paul Moisan ◽  
Mylène Bensmana ◽  
Paul Chuchana ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Restriction Site ◽  
Cell Receptor ◽  
Black African ◽  
Gamma Variable ◽  
Restriction Site Polymorphism ◽  
African Populations

Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and Black African populations

1989 ◽  
Vol 29 (3) ◽  
pp. 161-172 ◽  
Author(s):  
Catherine Buresi ◽  
Nada Ghanem ◽  
Sylvie Huck ◽  
G�rard Lefranc ◽  
Marie-Paule Lefranc
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Constant Region ◽  
Black African ◽  
Exon Duplication ◽  
Human T Cell ◽  
African Populations

Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating γδ T cells

2006 ◽  
Vol 58 (2-3) ◽  
pp. 138-151 ◽  
Author(s):  
Carolyn Herzig ◽  
Seth Blumerman ◽  
Marie-Paule Lefranc ◽  
Cynthia Baldwin
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Γδ T Cells ◽  
Cell Receptor ◽  
Gamma Variable

The human T-cell receptor gamma variable pseudogene V10 is a distinctive marker of human speciation

1996 ◽  
Vol 43 (4) ◽  
pp. 196-203 ◽  
Author(s):  
X.-M. Zhang ◽  
Guy Cathala ◽  
Zohra Soua ◽  
M.-P. Lefranc ◽  
S. Huck
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gamma Variable ◽  
Human T Cell

scholarly journals pmTR database: population matched (PM) germline allelic variants of T-cell receptor (TR) loci

2020 ◽  
Author(s):  
Julian Dekker ◽  
Jacques J.M. van Dongen ◽  
Marcel J.T. Reinders ◽  
Indu Khatri
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Receptor ◽  
Genetic Basis ◽  
Cell Receptor ◽  
Human Populations ◽  
Allelic Variants ◽  
Asian Populations ◽  
African Populations ◽  
Source Of Information

AbstractT-cell receptor (TR) germline alleles are arranged, organized and made available to the research community by the IMGT database. This state-of-the-art database, however, does not provide information regarding population specificity and allelic frequencies of the genes all four human TR loci (TRA, TRB, TRG and TRD). The specificity of allelic variants to different human populations can, however, be a rich source of information when studying the genetic basis of population-specific immune responses in vaccination and disease. To make TR germline alleles available for such population-specific studies, we meticulously identified true germline alleles enriched with complete TR allele sequences and their frequencies across 26 different human populations, profiled by “1,000 Genomes data”. We identified 205 TRAV, 249 TRBV, 16 TRGV and 5 TRDV germline alleles supported by at least four haplotypes (= minimum of two individuals). The diversity of germline allelic variants in the TR loci is highest in Africans followed by Non-African populations. A majority of the Non-African alleles are specific to the Asian populations, suggesting a diverse profile of TR germline alleles in different human populations. Interestingly, the alleles known in the IMGT database are frequent and common across all the superpopulations. We believe that this new set of genuine germline TR sequences represents a valuable new resource which we have made available through the new population-matched TR (pmTR) database, accessible via https://pmtrig.lumc.nl/.

Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population

1991 ◽  
Vol 86 (5) ◽  
Author(s):  
N. Ghanem ◽  
Z. Soua ◽  
X.G. Zhang ◽  
M. Zijun ◽  
Y. Zhiwei ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Chinese Population ◽  
Cell Receptor ◽  
Constant Region ◽  
Gamma Variable

The human T-cell receptor gamma variable pseudogeneV10 is a distinctive marker of human speciation

1996 ◽  
Vol 43 (4) ◽  
pp. 196-203 ◽  
Author(s):  
Xiao-Min Zhang ◽  
Guy Cathala ◽  
Zohra Soua ◽  
Marie-Paule Lefranc ◽  
Sylvie Huck
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gamma Variable ◽  
Human T Cell

scholarly journals Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures.

1993 ◽  
Vol 178 (6) ◽  
pp. 2201-2206 ◽  
Author(s):  
P M Appasamy ◽  
T W Kenniston ◽  
Y Weng ◽  
E C Holt ◽  
J Kost ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Fetal Liver ◽  
Variable Region ◽  
Cell Receptor ◽  
Gamma Variable ◽  
Interleukin 7 ◽  
Rag 1 ◽  
V Region ◽  
Variable Region Genes

We previously reported that culture of murine fetal liver (FL) cells with interleukin 7 (IL-7) results in expression of high levels of T cell receptor (TCR) gamma transcripts by a population of cells expressing Thy-1 and Pgp-1, suggesting that IL-7 promotes the growth and/or differentiation of pre-T cells. We demonstrate herein that culture of FL cells for 7 d with IL-7 caused the rearrangement and expression of TCR gamma variable (V) region genes V gamma 4 and V gamma 6, but not V gamma 5 or V gamma 7. Since this effect was not blocked by hydroxyurea, it appeared to represent induction of expression of these genes by IL-7 rather than expansion of a preexisting positive population. We also show that IL-7 induced RAG-1 and RAG-2 mRNA expression by FL cells. These data provide evidence that specific TCR gamma/delta V region genes can be rearranged and expressed by T lineage cells before their migration to the thymus, in response to IL-7.

Characterizing T-cell receptor gamma-variable gene in Aotus nancymaae owl monkey peripheral blood

2003 ◽  
Vol 62 (6) ◽  
pp. 472-482 ◽  
Author(s):  
J.E. Guerrero ◽  
D.P. Pacheco ◽  
C.F. Suarez ◽  
P. Martinez ◽  
F. Aristizabal ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Peripheral Blood ◽  
Cell Receptor ◽  
Gamma Variable ◽  
Owl Monkey ◽  
Variable Gene
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