Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population

1991 ◽  
Vol 86 (5) ◽  
Author(s):  
N. Ghanem ◽  
Z. Soua ◽  
X.G. Zhang ◽  
M. Zijun ◽  
Y. Zhiwei ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Chinese Population ◽  
Cell Receptor ◽  
Constant Region ◽  
Gamma Variable

scholarly journals Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Chaoting Zhang ◽  
Heyilimu Palashati ◽  
Zhuona Rong ◽  
Ningjing Lin ◽  
Luyan Shen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Therapeutic Efficacy ◽  
Terminal Differentiation ◽  
Cell Receptor ◽  
Constant Region ◽  
Car T ◽  
T Cell Malignancies ◽  
Β Chain

AbstractTargeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on anti-TRBC1 CAR transduced TRBC1+ T cells (CAR-C1) bound to autologous TRBC1, masking TRBC1 from identification by other anti-TRBC1 CAR-T, and moreover only the remaining unoccupied CARs recognized TRBC1+ cells, considerably reducing therapeutic potency of CAR-C1. In addition, co-culture of anti-TRBC1 CAR-T and TRBC1+ cells could promote exhaustion and terminal differentiation of CAR-T. These findings provide a rationale for pre-depleting TRBC1+ T cells before anti-TRBC1 CAR-T manufacturing.

A Highly Conserved Phenylalanine in the alpha, beta-T Cell Receptor (TCR) Constant Region Determines the Integrity of TCR/CD3 Complexes

1994 ◽  
Vol 40 (3) ◽  
pp. 323-336 ◽  
Author(s):  
S. CASPAR-BAUGUIL ◽  
J. ARNAUD ◽  
A. HUCHENQ ◽  
W. R. HEIN ◽  
C. GEISLER ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Constant Region ◽  
Alpha Beta

The human t cell receptor α-δ locus: a physical map of the variable, joining and constant region genes

1988 ◽  
Vol 18 (4) ◽  
pp. 641-644 ◽  
Author(s):  
Henrik Griesser ◽  
Erik Champagne ◽  
Douglas Tkachuk ◽  
Yoshihiro Takihara ◽  
Marc Lalande ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Physical Map ◽  
Cell Receptor ◽  
Constant Region ◽  
Human T Cell

A novel approach for preparing anti-T cell receptor constant region antibodies

1986 ◽  
Vol 16 (7) ◽  
pp. 851-854 ◽  
Author(s):  
Andre Traunecker ◽  
Beatrice Dolder ◽  
Klaus Karjalainen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Constant Region ◽  
Novel Approach

scholarly journals A unique RFLP in the human T-cell receptor γ constant region gene TRGC1

1989 ◽  
Vol 17 (1) ◽  
pp. 471-471 ◽  
Author(s):  
N. Ghanem ◽  
C. Buresi ◽  
G. Lefranc ◽  
M.-P. Lefranc
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Constant Region ◽  
Region Gene ◽  
Human T Cell ◽  
Constant Region Gene

scholarly journals Biological Function of the Extracellular Domain of the T-Cell Receptor Constant Region

1994 ◽  
Vol 39 (6) ◽  
pp. 517-525 ◽  
Author(s):  
B. RUBIN ◽  
J. ARNAUD ◽  
S. CASPAR-BAUGUIL ◽  
F. CONTE ◽  
A. HUCHENQ
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Biological Function ◽  
Extracellular Domain ◽  
Cell Receptor ◽  
Constant Region
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