Developmental origins of variation in human hand preference

Genetica ◽  
1993 ◽  
Vol 89 (1-3) ◽  
pp. 281-296 ◽  
Author(s):  
Ronald A. Yeo ◽  
Steven W. Gangestad
2021 ◽  
Vol 159 ◽  
pp. 103045
Author(s):  
Nele Zickert ◽  
Reint H. Geuze ◽  
Bernd Riedstra ◽  
Ton G.G. Groothuis

2019 ◽  
Author(s):  
Eric J. Horstick ◽  
Yared Bayleyen ◽  
Harold A. Burgess

AbstractAsymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the epithalamic commissure to the habenula. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that developmental pathways that establish visceral asymmetries also govern acquisition of left/right identity.


1985 ◽  
Vol 15 (4) ◽  
pp. 385-400 ◽  
Author(s):  
N. Risch ◽  
G. Pringle

1976 ◽  
Author(s):  
C. W. Suggs ◽  
John Wayne Mishoe

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