Risk of plutonium and241Am uptake by radiochemical plant workers through injured skin

Atomic Energy ◽  
1994 ◽  
Vol 77 (6) ◽  
pp. 928-931
Author(s):  
V. F. Khokhryakov ◽  
T. I. Kudryavtseva ◽  
V. A. Shevkunov
Keyword(s):  
Radiochemical Plant ◽  
Injured Skin

34 Rete Ridges are Decreased in Dyschromic Burn Hypertrophic Scar: A Histological Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S27-S27
Author(s):  
Bonnie C Carney ◽  
Taryn E Travis ◽  
Romina Deldar ◽  
Lauren T Moffatt ◽  
Laura S Johnson ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Hypertrophic Scar ◽  
Burn Injury ◽  
Histological Study ◽  
Normal Skin ◽  
Weak Correlation ◽  
Rete Ridge ◽  
Skin Physiology ◽  
Predominantly Female ◽  
Injured Skin

Abstract Introduction Dyschromic hypertrophic scar (HTS) with areas of hyper- and hypo-pigmentation is a common sequelae of burn injury. The mechanism behind the development of dyschromia has not been elucidated. In this study, we provide a histological analysis of these scars with a focus on rete ridge presence. Rete ridges occur in epithelial tissues such as oral mucosa and skin and can be described as undulating “pegs” that are interdigitated with dermal papillae. Rete ridges enhance adhesion of the epidermis to the dermis. We hypothesize that rete ridge presence is important for normal skin physiology, and their absence or presence may hold mechanistic significance in post-burn HTS dyschromia. Methods Subjects with post-burn dyschromic HTS were consented and enrolled (n=27). Punch biopsies of hyper-, hypo-, and normally pigmented scar and skin were collected and stored in formalin. Biopsies were paraffin embedded, sectioned, stained with H&E, and imaged. The number of rete ridges were investigated by calculating a rete ridge ratio from the length of the basement membrane and the length of the epidermis. Results The patient population was predominantly female (55.5%), black (70.4%), and had Fitzpatrick skin Type V (51.9%). The injuries were primarily as a result of flame (37%) and scald (33.3%) and resulted in a median TBSA burn of 7%. The median age of the scar at the time of sample acquisition was 12.2 months. The rete ridge ratio of normally pigmented, un-injured skin was above 1 (1.31 ± 0.04), indicating that normal skin’s basement membrane is longer than its epidermal length due to the presence of rete ridges. HTSs resulting from burn wounds that healed without split thickness autografts were first investigated. The number of rete ridges was higher in normal skin compared to HTS that was either hypo- or hyperpigmented (1.31 ± 0.04 vs. 1.13 ± 0.05 and 1.14 ± 0.04 vs, p< 0.05). This difference was similar despite pigmentation phenotype. When hyper-pigmented scars resulting from wounds that were treated with split thickness autografts (Hyper(+)) were investigated, rete ridge number was significantly higher than in Hyper(-) (1.89 ± 0.23, p< 0.01). Patient age showed a weak correlation (R=-0.33) with rete ridge ratio where older patients had lower rete ridge ratios in normal, un-injured skin. Hyper(+) showed a weak correlation between rete ridge ratio and age of scar (R=-0.38). Conclusions Post-burn HTS that is dyschromic has fewer rete ridges than normal skin. This finding may explain the decreased epidermal barrier function that is associated with HTS.

scholarly journals Evaluation of EPS-PCL Nanofibers as a Nanobiocomposite for Artificial Skin Based on Dermal Fibroblast Culture

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sang-Myung Jung ◽  
Dae Seung Kim ◽  
Jung Hyeon Ju ◽  
Hwa Sung Shin
Keyword(s):  
High Cell Density ◽  
Undaria Pinnatifida ◽  
Dermal Fibroblast ◽  
Bioactive Molecules ◽  
Artificial Skin ◽  
Limited Area ◽  
High Cell ◽  
Electrospinning Technique ◽  
Primary Fibroblasts ◽  
Injured Skin

Several natural bioactive molecules have been used in the development of scaffolds to enhance biocompatibility or biodegradability and macroalgae contain many bioactive compounds that regulate the physiological activities of cells. In this study, extrapolymeric substances (EPS) from brown algae,Undaria pinnatifida, were dispersed in poly-ε-caprolactone (PCL) nanofiber, fabricated by electrospinning technique to mimic natural extracellular matrix (ECM), and tested as a scaffold for the production of artificial skin using rat primary fibroblasts. The level of adhesion, viability, and infiltration of cells on the EPS-PCL nanofibers were then assessed. The primary fibroblasts attached well, had good viability, and infiltrated through the nanofiber mat without cytotoxicity. Additionally, fibroblast on EPS-PCL nanofiber overcame the stress derived from high cell density at limited area. These results indicate that EPS-imbedded nanofiber has the potential to be used as scaffolds to develop artificial skin or as wound-healing nanomedicines to regenerate injured skin.

Injured skin as risk factor for chlorhexidine anaphylaxis

2018 ◽  
Vol 6 (6) ◽  
pp. 2177 ◽  
Author(s):  
Gianfranco Calogiuri ◽  
Lene Heise Garvey ◽  
Elisabetta DiLeo ◽  
Eustachio Nettis ◽  
Angelo Vacca ◽  
...  
Keyword(s):  
Risk Factor ◽  
Injured Skin

Application of hyperosmolar glucose on injured skin

2002 ◽  
pp. 199-201
Author(s):  
S Kim ◽  
E Jerschow ◽  
S Yun ◽  
J Kim ◽  
Y Won
Keyword(s):  
Injured Skin ◽  
Hyperosmolar Glucose

scholarly journals Investigation of Borosilicate Glasses with Simulated HLW Components and Determination of Their Chemical Durability

2021 ◽  
Vol 8 (1) ◽  
pp. 20218105
Author(s):  
S. M. Shaydullin ◽  
E. A. Belanova ◽  
P. V. Kozlov ◽  
M. B. Remizov ◽  
E. M. Dvoryanchikova
Keyword(s):  
Chemical Durability ◽  
Current Status ◽  
Borosilicate Glasses ◽  
Radiochemical Plant ◽  
Technical Solutions

The paper discusses the current status of the HLW vitrification technology applied at the radiochemical plant of the Mayak PA. Conceptual and technical solutions proposed to develop the technology of vitrification of various types of liquid HLW at the Mayak PA are presented. Compositions of borosilicate glasses with HLW components are described, temperatures of their melting and easy pouring are determined. Chemical durability parameters obtained for the borosilicate glasses are provided.

scholarly journals Changes in peripheral nervous system at participants of accident consequences elimination in Chernobyl APP and population of the Tomsk northern industrial center

2004 ◽  
Vol 3 (4) ◽  
pp. 71-80
Author(s):  
Ya. V. Porovsky ◽  
V. I. Zhankova ◽  
A. I. Ryzhov ◽  
Ye. V. Kalyanov ◽  
F. F. Tetenev
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Peripheral Nervous System ◽  
Radiochemical Plant ◽  
Chemical Complex ◽  
Tomsk Region ◽  
Industrial Center ◽  
Sensory Polyneuropathy ◽  
Siberian Chemical

A clinical, electroneuromyographic (ENMG) and pathomorphological investigation of 19 eliminators of accident consequences (EAC) in Chernobyl APP in 1986 and 27 Tomsk region inhabitants living in the accident area that has taken place at radiochemical plant of Siberian Chemical Complex in 1993 has been made with the aim of the influence study of low ionizing radiation levels on the peripheral nervous system. Symptoms of sensory polyneuropathy prevailed in both groups clinically. Mixed affection type has been found at EAC by ENGM method, affection of myelinic nerve fibre membrane has been found at people living in accident trace area. Morphofunctional changes in skin allow considering the role of immune system in mechanisms of neuroglial and neuronal damages, distant by time.

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